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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1924 1
1926 1
1929 1
1930 1
1941 2
1952 1
1955 1
1957 1
1958 1
1968 1
1975 7
1976 4
1977 1
1978 4
1979 3
1980 2
1981 3
1982 1
1983 5
1984 1
1985 2
1986 2
1987 3
1988 4
1989 2
1990 6
1991 6
1992 7
1993 4
1994 7
1995 11
1996 3
1997 9
1998 1
1999 14
2000 13
2001 11
2002 6
2003 9
2004 10
2005 10
2006 3
2007 12
2008 9
2009 7
2010 5
2011 11
2012 7
2013 15
2014 11
2015 12
2016 6
2017 7
2018 10
2019 7
2020 12
2021 11
2022 9
2023 2
2024 8

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324 results

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Page 1
Regulation of coagulation by tissue factor pathway inhibitor: Implications for hemophilia therapy.
Mast AE, Ruf W. Mast AE, et al. J Thromb Haemost. 2022 Jun;20(6):1290-1300. doi: 10.1111/jth.15697. Epub 2022 Mar 27. J Thromb Haemost. 2022. PMID: 35279938 Free PMC article. Review.
Both forms directly inhibit factor Xa (FXa) via their Kunitz 2 domain and inhibit TF-FVIIa via their Kunitz 1 domain in a tight complex primarily localized to cells. ...This regulation of thrombin generation in the context of vessel injury is effectively blocked by …
Both forms directly inhibit factor Xa (FXa) via their Kunitz 2 domain and inhibit TF-FVIIa via their Kunitz 1 domain in a tigh …
Lipocalins and cancer.
Bratt T. Bratt T. Biochim Biophys Acta. 2000 Oct 18;1482(1-2):318-26. doi: 10.1016/s0167-4838(00)00154-0. Biochim Biophys Acta. 2000. PMID: 11058772 Review.
In vitro-engineered non-antibody protein therapeutics.
Simeon R, Chen Z. Simeon R, et al. Protein Cell. 2018 Jan;9(1):3-14. doi: 10.1007/s13238-017-0386-6. Epub 2017 Mar 7. Protein Cell. 2018. PMID: 28271446 Free PMC article. Review.
Scaffolds that fall under the first category include adnectins, anticalins, avimers, Fynomers, Kunitz domains, and knottins, while those belonging to the second category include affibodies, beta-hairpin mimetics, and designed ankyrin repeat proteins (DARPins). ...
Scaffolds that fall under the first category include adnectins, anticalins, avimers, Fynomers, Kunitz domains, and knottins, while th …
Molecular Characterization of Kunitz-Type Protease Inhibitors from Blister Beetles (Coleoptera, Meloidae).
Fratini E, Rossi MN, Spagoni L, Riccieri A, Mancini E, Polticelli F, Bologna MA, Mariottini P, Cervelli M. Fratini E, et al. Biomolecules. 2022 Jul 15;12(7):988. doi: 10.3390/biom12070988. Biomolecules. 2022. PMID: 35883544 Free PMC article.
Natural protease inhibitors have the advantage to be reversible and with few side effects and thus are increasingly considered as new drugs. Kunitz-type protease inhibitors (KTPIs), reported in the venom of various organisms, such as wasps, spiders, scorpions, and snakes, …
Natural protease inhibitors have the advantage to be reversible and with few side effects and thus are increasingly considered as new drugs. …
Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model.
Sintsova O, Gladkikh I, Monastyrnaya M, Tabakmakher V, Yurchenko E, Menchinskaya E, Pislyagin E, Andreev Y, Kozlov S, Peigneur S, Tytgat J, Aminin D, Kozlovskaya E, Leychenko E. Sintsova O, et al. Biomedicines. 2021 Mar 10;9(3):283. doi: 10.3390/biomedicines9030283. Biomedicines. 2021. PMID: 33802055 Free PMC article.
Kunitz-type peptides from venomous animals have been known to inhibit different proteinases and also to modulate ion channels and receptors, demonstrating analgesic, anti-inflammatory, anti-histamine and many other biological activities. At present, there is evidence of th …
Kunitz-type peptides from venomous animals have been known to inhibit different proteinases and also to modulate ion channels and rec …
The Kunitz chymotrypsin inhibitor from Erythrina velutina seeds displays activity against HeLa cells through arrest in cell cycle.
Lucena SV, Rufino FP, de Dantas Moura GED, Rabêlo LMA, Monteiro NKV, Ferreira AT, Perales JEA, Uchôa AF, Justo GZ, de Oliveira CFR, Migliolo L, Nader HB, Santos EA, Oliveira AS. Lucena SV, et al. 3 Biotech. 2022 Jan;12(1):19. doi: 10.1007/s13205-021-03084-0. Epub 2021 Dec 15. 3 Biotech. 2022. PMID: 34926123 Free PMC article.
The aim of this study was to purify and characterize a novel Kunitz-type peptidase inhibitor from Erythrina velutina seeds and evaluate its anti-proliferative effects against cancer cell lines. ...The purified EvCI has a molecular mass of 18 kDa with homology to a Kunit …
The aim of this study was to purify and characterize a novel Kunitz-type peptidase inhibitor from Erythrina velutina seeds and evalua …
Unveiling Novel Kunitz- and Waprin-Type Toxins in the Micrurus mipartitus Coral Snake Venom Gland: An In Silico Transcriptome Analysis.
Saldarriaga-Córdoba M, Clavero-León C, Rey-Suarez P, Nuñez-Rangel V, Avendaño-Herrera R, Solano-González S, Alzate JF. Saldarriaga-Córdoba M, et al. Toxins (Basel). 2024 May 11;16(5):224. doi: 10.3390/toxins16050224. Toxins (Basel). 2024. PMID: 38787076 Free PMC article.
Transcriptomic analysis revealed a high diversity of venom-associated Kunitz serine protease inhibitor proteins (KSPIs). A total of eight copies of KSPIs were predicted and grouped into four distinctive types, including short KSPI, long KSPI, Kunitz-Waprin (Ku-WAP) …
Transcriptomic analysis revealed a high diversity of venom-associated Kunitz serine protease inhibitor proteins (KSPIs). A total of e …
A new Kunitz trypsin inhibitor from Erythrina poeppigiana exhibits antimicrobial and antibiofilm properties against bacteria.
Alencar de Barros KM, Sardi JCO, Maria-Neto S, Macedo AJ, Ramalho SR, Lourenço de Oliveira DG, Pontes GS, Weber SS, Ramalho de Oliveira CF, Macedo MLR. Alencar de Barros KM, et al. Biomed Pharmacother. 2021 Dec;144:112198. doi: 10.1016/j.biopha.2021.112198. Epub 2021 Oct 15. Biomed Pharmacother. 2021. PMID: 34656058 Free article.
Herein, we described the purification and characterization of a new Kunitz-type inhibitor, obtained from E. poeppigiana seeds (EpTI). EpTI is composed by three isoforms of identical amino-terminal sequences with a molecular weight ranging from 17 to 20 kDa. ...The inhibito …
Herein, we described the purification and characterization of a new Kunitz-type inhibitor, obtained from E. poeppigiana seeds (EpTI). …
The landscape of genetic aberrations in myxofibrosarcoma.
Takeuchi Y, Yoshida K, Halik A, Kunitz A, Suzuki H, Kakiuchi N, Shiozawa Y, Yokoyama A, Inoue Y, Hirano T, Yoshizato T, Aoki K, Fujii Y, Nannya Y, Makishima H, Pfitzner BM, Bullinger L, Hirata M, Jinnouchi K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Okamoto T, Haga H, Ogawa S, Damm F. Takeuchi Y, et al. Int J Cancer. 2022 Aug 15;151(4):565-577. doi: 10.1002/ijc.34051. Epub 2022 May 13. Int J Cancer. 2022. PMID: 35484982 Free article.
Snake venomics and venom gland transcriptomic analysis of Brazilian coral snakes, Micrurus altirostris and M. corallinus.
Corrêa-Netto C, Junqueira-de-Azevedo Ide L, Silva DA, Ho PL, Leitão-de-Araújo M, Alves ML, Sanz L, Foguel D, Zingali RB, Calvete JJ. Corrêa-Netto C, et al. J Proteomics. 2011 Aug 24;74(9):1795-809. doi: 10.1016/j.jprot.2011.04.003. Epub 2011 Apr 12. J Proteomics. 2011. PMID: 21515432
Transcriptomic data provided the full-length amino acid sequences of 18 (M. altirostris) and 10 (M. corallinus) 3FTxs, and 3 (M. altirostris) and 1 (M. corallinus) novel PLA(2) sequences. In addition, venom from each species contained single members of …
Transcriptomic data provided the full-length amino acid sequences of 18 (M. altirostris) and 10 (M. corallinus) 3FTxs, and 3 ( …
324 results