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Page 1
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators. Das Pradhan A, et al. N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5. N Engl J Med. 2022. PMID: 36342113 Clinical Trial.
Final Report of a Trial of Intensive versus Standard Blood-Pressure Control.
SPRINT Research Group; Lewis CE, Fine LJ, Beddhu S, Cheung AK, Cushman WC, Cutler JA, Evans GW, Johnson KC, Kitzman DW, Oparil S, Rahman M, Reboussin DM, Rocco MV, Sink KM, Snyder JK, Whelton PK, Williamson JD, Wright JT Jr, Ambrosius WT. SPRINT Research Group, et al. N Engl J Med. 2021 May 20;384(20):1921-1930. doi: 10.1056/NEJMoa1901281. N Engl J Med. 2021. PMID: 34010531 Free PMC article. Clinical Trial.
Cardiomyocyte PANX1 Controls Glycolysis and Neutrophil Recruitment in Hypertrophy.
Pavelec CM, Young AP, Luviano HL, Orrell EE, Szagdaj A, Poudel N, Wolpe AG, Thomas SH, Yeudall S, Upchurch CM, Okusa MD, Isakson BE, Wolf MJ, Leitinger N. Pavelec CM, et al. Circ Res. 2024 Aug 2;135(4):503-517. doi: 10.1161/CIRCRESAHA.124.324650. Epub 2024 Jul 3. Circ Res. 2024. PMID: 38957990
Moreover, we found that Panx1(MyHC6) mice showed decreased isoproterenol-induced recruitment of immune cells (CD45(+)), particularly neutrophils (CD11b(+) [integrin subunit alpha M], Ly6g(+) [lymphocyte antigen 6 family member G]), to the myocardium. CONCLUSIONS: Together, …
Moreover, we found that Panx1(MyHC6) mice showed decreased isoproterenol-induced recruitment of immune cells (CD45(+)), particularly neutrop …
Controlled Trial of Budesonide-Formoterol as Needed for Mild Asthma.
Beasley R, Holliday M, Reddel HK, Braithwaite I, Ebmeier S, Hancox RJ, Harrison T, Houghton C, Oldfield K, Papi A, Pavord ID, Williams M, Weatherall M; Novel START Study Team. Beasley R, et al. N Engl J Med. 2019 May 23;380(21):2020-2030. doi: 10.1056/NEJMoa1901963. Epub 2019 May 19. N Engl J Med. 2019. PMID: 31112386 Clinical Trial.
The annualized exacerbation rate in the budesonide-formoterol group was lower than that in the albuterol group (absolute rate, 0.195 vs. 0.400; relative rate, 0.49; 95% confidence interval [CI], 0.33 to 0.72; P<0.001) and did not differ significantly from the rate in th …
The annualized exacerbation rate in the budesonide-formoterol group was lower than that in the albuterol group (absolute rate, 0.195 vs. 0.4 …
Thiol-catalyzed formation of NO-ferroheme regulates intravascular NO signaling.
DeMartino AW, Poudel L, Dent MR, Chen X, Xu Q, Gladwin BS, Tejero J, Basu S, Alipour E, Jiang Y, Rose JJ, Gladwin MT, Kim-Shapiro DB. DeMartino AW, et al. Nat Chem Biol. 2023 Oct;19(10):1256-1266. doi: 10.1038/s41589-023-01413-3. Epub 2023 Sep 14. Nat Chem Biol. 2023. PMID: 37710075 Free PMC article.
Targeting RSV-neutralizing B cell receptors with anti-idiotypic antibodies.
Scharffenberger SC, Wan YH, Homad LJ, Kher G, Haynes AM, Poudel B, Sinha IR, Aldridge N, Pai A, Bibby M, Chhan CB, Davis AR, Moodie Z, Palacio MB, Escolano A, McElrath MJ, Boonyaratanakornkit J, Pancera M, McGuire AT. Scharffenberger SC, et al. Cell Rep. 2024 Oct 22;43(10):114811. doi: 10.1016/j.celrep.2024.114811. Epub 2024 Oct 8. Cell Rep. 2024. PMID: 39383036 Free PMC article.
66 results