Synthesis, design, biological evaluation, and computational analysis of some novel uracil-azole derivatives as cytotoxic agents.
Emami L, Zare F, Khabnadideh S, Rezaei Z, Sabahi Z, Zare Gheshlaghi S, Behrouz M, Emami M, Ghobadi Z, Madadelahi Ardekani S, Barzegar F, Ebrahimi A, Sabet R.
Emami L, et al.
BMC Chem. 2024 Jan 3;18(1):3. doi: 10.1186/s13065-023-01106-x.
BMC Chem. 2024.
PMID: 38173035
Free PMC article.
Among these compounds, 4j displayed the best selectivity profile and good activity with IC(50) values of 16.18 1.02 and 7.56 5.28 M against MCF-7 and HEPG-2 cell lines respectively. Structure-activity relationships revealed that the variation in the cytotoxic potency of th …
Among these compounds, 4j displayed the best selectivity profile and good activity with IC(50) values of 16.18 1.02 and 7.56 5.28 M a …