Methadone dosing strategies in preterm neonates can be simplified.
van Donge T, Samiee-Zafarghandy S, Pfister M, Koch G, Kalani M, Bordbar A, van den Anker J.
van Donge T, et al.
Br J Clin Pharmacol. 2019 Jun;85(6):1348-1356. doi: 10.1111/bcp.13906. Epub 2019 Apr 10.
Br J Clin Pharmacol. 2019.
PMID: 30805946
Free PMC article.
A population PK model was built to characterize developmental PK of (R)- and (S)-methadone. Model-based simulations were performed to identify a simplified dosing strategy to reach and maintain target methadone exposure. ...A one-compartment model with first order absorpti …
A population PK model was built to characterize developmental PK of (R)- and (S)-methadone. Model-based simulations were performed to …