High-throughput multiplexed serology via the mass-spectrometric analysis of isotopically barcoded beads.
Drainas AP, McIlwain DR, Dallas A, Chu T, Delgado-González A, Baron M, Angulo-Ibáñez M, Trejo A, Bai Y, Hickey JW, Lu G, Lu S, Pineda-Ramirez J, Anglin K, Richardson ET, Prostko JC, Frias E, Servellita V, Brazer N, Chiu CY, Peluso MJ, Martin JN, Wirz OF, Pham TD, Boyd SD, Kelly JD, Sage J, Nolan GP, Rovira-Clavé X.
Drainas AP, et al.
Nat Biomed Eng. 2025 Jul;9(7):1117-1128. doi: 10.1038/s41551-025-01349-0. Epub 2025 Feb 12.
Nat Biomed Eng. 2025.
PMID: 39939547
Free PMC article.
We generated 18,480 unique isotopically barcoded beads to simultaneously detect, in a single tube with 924 serum samples, the levels of immunoglobulins G and M against 19 proteins from SARS-CoV-2 (a total of 36,960 tests in 400 nl of sample volume and 30 mul of reaction vo …
We generated 18,480 unique isotopically barcoded beads to simultaneously detect, in a single tube with 924 serum samples, the levels of immu …