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The IL-22-oncostatin M axis promotes intestinal inflammation and tumorigenesis.
Cineus R, Luo Y, Saliutina M, Manna S, Cancino CA, Velasco Blázquez L, Wang L, Bösel D, Abdelrahman A, Klementowicz JE, Scherl A, Hainbuch S, Bréart B, Kwon G, Konopka A, Guerra GM, von Coburg E, Gerbeth L, Roels J, Heinrich F, Müller N, Durek P, Deigendesch N, Ziai J, Hung J, Conrad T; TRR241 IBDome Consortium; Kühl AA, Wirtz S, Löhning M, Keir M, Diefenbach A, Mashreghi MF, Siegmund B, Schumann M, Romagnani C, West NR, Hegazy AN. Cineus R, et al. Nat Immunol. 2025 Jun;26(6):837-853. doi: 10.1038/s41590-025-02149-z. Epub 2025 May 30. Nat Immunol. 2025. PMID: 40447860 Free PMC article.
Here, we identify that IL-22 directly induces responsiveness to the IL-6 family cytokine oncostatin M (OSM) in intestinal epithelial cells (IECs) by activating STAT3 and upregulating the OSM receptor. ...
Here, we identify that IL-22 directly induces responsiveness to the IL-6 family cytokine oncostatin M (OSM) in intestinal epithelial …
TGFβ links EBV to multisystem inflammatory syndrome in children.
Goetzke CC, Massoud M, Frischbutter S, Guerra GM, Ferreira-Gomes M, Heinrich F, von Stuckrad ASL, Wisniewski S, Licha JR, Bondareva M, Ehlers L, Khaldi-Plassart S, Javouhey E, Pons S, Trouillet-Assant S, Ozsurekci Y, Zhang Y, Poli MC, Discepolo V, Lo Vecchio A, Sahin B, Verboom M, Hallensleben M, Heuhsen AI, Astudillo C, Espinosa Y, Vial Cox MC, Dobbs K, Delmonte OM, Montealegre Sanchez GA, Magliocco M, Barron K, Danielson J, Petrov L, Unterwalder N, Sawitzki B, Matz M, Lehmann K, Gratopp A, von Bernuth H, Burkhardt LM, Wiese N, Peter L, Schmueck-Henneresse M, Amini L, Maurer M, Roehmel JF, Gewurz BE, Yonker LM, Witkowski M, Kruglov A, Mall MA, Su HC, Ozen S, Radbruch A, Belot A, Durek P, Kallinich T, Mashreghi MF. Goetzke CC, et al. Nature. 2025 Apr;640(8059):762-771. doi: 10.1038/s41586-025-08697-6. Epub 2025 Mar 12. Nature. 2025. PMID: 40074901 Free PMC article.
MicroRNA-223 Dampens Pulmonary Inflammation during Pneumococcal Pneumonia.
Goekeri C, Pennitz P, Groenewald W, Behrendt U, Kirsten H, Zobel CM, Berger S, Heinz GA, Mashreghi MF, Wienhold SM, Dietert K, Dorhoi A, Gruber AD, Scholz M, Rohde G, Suttorp N, Capnetz Study Group, Witzenrath M, Nouailles G. Goekeri C, et al. Cells. 2023 Mar 21;12(6):959. doi: 10.3390/cells12060959. Cells. 2023. PMID: 36980300 Free PMC article.
A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics.
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G. Pennitz P, et al. Eur Respir Rev. 2022 Jul 27;31(165):220056. doi: 10.1183/16000617.0056-2022. Print 2022 Sep 30. Eur Respir Rev. 2022. PMID: 35896273 Free PMC article. Review.
Icariin: A Promising Natural Product in Biomedicine and Tissue Engineering.
Seyedi Z, Amiri MS, Mohammadzadeh V, Hashemzadeh A, Haddad-Mashadrizeh A, Mashreghi M, Qayoomian M, Hashemzadeh MR, Simal-Gandara J, Taghavizadeh Yazdi ME. Seyedi Z, et al. J Funct Biomater. 2023 Jan 12;14(1):44. doi: 10.3390/jfb14010044. J Funct Biomater. 2023. PMID: 36662090 Free PMC article. Review.
Moreover, cancer cells no longer grow by halting the cell cycle at two checkpoints, G0/G1 and G2/M, through the inhibition of NF-kappaB by ICRN. Besides, improving nephrotoxicity occurring due to cisplatin and inhibiting multidrug resistance are the other applications of t …
Moreover, cancer cells no longer grow by halting the cell cycle at two checkpoints, G0/G1 and G2/M, through the inhibition of NF-kapp …
Characterization of stability, safety and immunogenicity of the mRNA lipid nanoparticle vaccine Iribovax® against COVID-19 in nonhuman primates.
Zamani P, Mashreghi M, Rezazade Bazaz M, Zargari S, Alizadeh F, Dorrigiv M, Abdoli A, Aminianfar H, Hatamipour M, Zarqi J, Behboodifar S, Samsami Y, Khorshid Sokhangouy S, Sefidbakht Y, Uskoković V, Rezayat SM, Jaafari MR, Mozaffari-Jovin S. Zamani P, et al. J Control Release. 2023 Aug;360:316-334. doi: 10.1016/j.jconrel.2023.06.025. Epub 2023 Jul 5. J Control Release. 2023. PMID: 37355212
Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients.
Peter L, Wendering DJ, Schlickeiser S, Hoffmann H, Noster R, Wagner DL, Zarrinrad G, Münch S, Picht S, Schulenberg S, Moradian H, Mashreghi MF, Klein O, Gossen M, Roch T, Babel N, Reinke P, Volk HD, Amini L, Schmueck-Henneresse M. Peter L, et al. Mol Ther Methods Clin Dev. 2022 Jun 9;25:52-73. doi: 10.1016/j.omtm.2022.02.012. Epub 2022 Feb 26. Mol Ther Methods Clin Dev. 2022. PMID: 35252469 Free PMC article.
Development of a bacterial cellulose-gelatin composite as a suitable scaffold for cardiac tissue engineering.
Salehghamari M, Mashreghi M, Matin MM, Neshati Z. Salehghamari M, et al. Biotechnol Lett. 2024 Oct;46(5):887-905. doi: 10.1007/s10529-024-03477-0. Epub 2024 May 21. Biotechnol Lett. 2024. PMID: 38771508
RESULTS: The average nanofibrils diameter in all scaffolds was suitable (~ 30-65 nm) for nr-vCMCs culture. Pore diameter ( 10 m), surface roughness (~ 182 nm), elastic modulus (0.075 0.015 MPa) in mBCG were in accordance with cardiomyocyte requirements, so that mBCG co …
RESULTS: The average nanofibrils diameter in all scaffolds was suitable (~ 30-65 nm) for nr-vCMCs culture. Pore diameter ( 10 m), s …
12 results