Astragaloside IV Pretreatment Alleviates Pulmonary Ischemia-Reperfusion Injury via the TLR4/MyD88/NF-κB p65 Pathway in Rats.
Tian XR, Zhao JH, Yin XH, Lin JH, Liang SM, Xu XQ, Li KY, Fan TS, Xiong P.
Tian XR, et al.
Phytother Res. 2025 Oct;39(10):4744-4765. doi: 10.1002/ptr.70039. Epub 2025 Sep 4.
Phytother Res. 2025.
PMID: 40907985
In vivo, the PIRI model was induced in SD rats. The lung tissue W/D ratio and pathological morphology, as well as the markers of oxidative stress, were monitored. ...SPR further confirmed that ASIV rapidly bound to the rhTLR4-MD-2 complex with a K(D) of 2.17 10(-6) M …
In vivo, the PIRI model was induced in SD rats. The lung tissue W/D ratio and pathological morphology, as well as the markers of oxid …