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Did you mean M. ahmad (4,056 results)?
Kisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro.
Simon C, Soga T, Ahemad N, Bhuvanendran S, Parhar I. Simon C, et al. Int J Mol Sci. 2022 May 6;23(9):5193. doi: 10.3390/ijms23095193. Int J Mol Sci. 2022. PMID: 35563582 Free PMC article.
Remarkably, the E46K mutant alpha-syn displayed elevated alpha-syn mRNA levels, which subsequently induced more cellular toxicity compared with the wild-type alpha-syn in choline acetyltransferase (ChAT)-positive cholinergic neurons. Treatment with a high concentration of KP-10 ( …
Remarkably, the E46K mutant alpha-syn displayed elevated alpha-syn mRNA levels, which subsequently induced more cellular toxicity compared w …
In vitro inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6.
Tan BH, Ahemad N, Pan Y, Palanisamy UD, Othman I, Ong CE. Tan BH, et al. Drug Metab Pers Ther. 2021 Apr 9;36(4):259-270. doi: 10.1515/dmpt-2020-0182. Drug Metab Pers Ther. 2021. PMID: 34821124
All glucosamines and chondroitins weakly inhibited CYP2D6 (IC(50) values >300 M). Diacerein exhibited moderate inhibition with IC(50) and K(i) values of 34.99 and 38.27 M, respectively. ...
All glucosamines and chondroitins weakly inhibited CYP2D6 (IC(50) values >300 M). Diacerein exhibited moderate inhibition with IC( …
High-throughput virtual screening, pharmacophore modelling and antagonist effects of small molecule inhibitors against cytotoxin-induced cytotoxicity.
Lim EQ, Ahemad N, Yap MKK. Lim EQ, et al. J Biomol Struct Dyn. 2023 Dec 15:1-15. doi: 10.1080/07391102.2023.2293275. Online ahead of print. J Biomol Struct Dyn. 2023. PMID: 38100546
The antagonist effects of these hits on CTX-induced cytotoxicity were examined in human keratinocytes (HaCaT). Despite having a low binding affinity (K(D) = 14.45 10(-)(4) M), acenaphthene demonstrated a significant increase of cell viability at 6 h and 24 h in experimenta …
The antagonist effects of these hits on CTX-induced cytotoxicity were examined in human keratinocytes (HaCaT). Despite having a low binding …
In vitro inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6.
Tan BH, Ahemad N, Pan Y, Palanisamy UD, Othman I, Ong CE. Tan BH, et al. Drug Metab Pers Ther. 2021 Apr 8. doi: 10.1515/dmdi-2020-0182. Online ahead of print. Drug Metab Pers Ther. 2021. PMID: 33831979
All glucosamines and chondroitins weakly inhibited CYP2D6 (IC(50) values >300 M). Diacerein exhibited moderate inhibition with IC(50) and K (i) values of 34.99 and 38.27 M, respectively. ...
All glucosamines and chondroitins weakly inhibited CYP2D6 (IC(50) values >300 M). Diacerein exhibited moderate inhibition with IC( …
Probing the molecular interactions between cholinium-based ionic liquids and insulin aspart: A combined computational and experimental study.
Sundaram V, Ramanan RN, Selvaraj M, Ahemad N, Vijayaraghavan R, MacFarlane DR, Ooi CW. Sundaram V, et al. Int J Biol Macromol. 2023 Dec 31;253(Pt 3):126665. doi: 10.1016/j.ijbiomac.2023.126665. Epub 2023 Sep 7. Int J Biol Macromol. 2023. PMID: 37689282 Free article.
In this work, we used a combined computational and experimental approach to investigate the structural stability of a peptide hormone, insulin aspart (IA), in ILs containing a choline cation [Ch](+) and either dihydrogen phosphate ([Dhp](-)) or acetate ([Ace](-)) as anions. Altho …
In this work, we used a combined computational and experimental approach to investigate the structural stability of a peptide hormone, insul …
Discovery of oxindole-based FLT3 inhibitors as a promising therapeutic lead for acute myeloid leukemia carrying the oncogenic ITD mutation.
Bender O, Shoman ME, Ali TFS, Dogan R, Celik I, Mollica A, Hamed MIA, Aly OM, Alamri A, Alanazi J, Ahemad N, Gan SH, Malik JA, Anwar S, Atalay A, Beshr EAM. Bender O, et al. Arch Pharm (Weinheim). 2023 Feb;356(2):e2200407. doi: 10.1002/ardp.202200407. Epub 2022 Nov 20. Arch Pharm (Weinheim). 2023. PMID: 36403191
The most potent compound 5a inhibited MV4-11 cells with IC(50) of 4.3 M at 72 h while it was 8.7 M in THP-1 cells, thus showing two-fold selective inhibition against the oncogenic ITD mutation. ...Mechanistically, compounds 5a and 5b inhibited FLT3 kinase with IC(50 …
The most potent compound 5a inhibited MV4-11 cells with IC(50) of 4.3 M at 72 h while it was 8.7 M in THP-1 cells, thus showin …
Metabolic fingerprinting, antioxidant characterization, and enzyme-inhibitory response of Monotheca buxifolia (Falc.) A. DC. extracts.
Ali JS, Saleem H, Mannan A, Zengin G, Mahomoodally MF, Locatelli M, Abidin SAZ, Ahemad N, Zia M. Ali JS, et al. BMC Complement Med Ther. 2020 Oct 16;20(1):313. doi: 10.1186/s12906-020-03093-1. BMC Complement Med Ther. 2020. PMID: 33066787 Free PMC article.
CONCLUSIONS: UHPLC-MS analysis and HPLC-PDA quantification identified a number of bioactive secondary metabolites of M. buxifolia, which may be responsible for its antioxidant potential and enzyme-inhibitory response. M. buxifolia can be further explored for the iso …
CONCLUSIONS: UHPLC-MS analysis and HPLC-PDA quantification identified a number of bioactive secondary metabolites of M. buxifolia, wh …