Designing Potent Anticancer Peptides by Aurein 1.2 Key Residues Mutation and Catenate Cell-Penetrating Peptide.
Salarpour Garnaie H, Shahabi A, Geranmayeh MH, Barzegar A, Yari Khosroushahi A.
Salarpour Garnaie H, et al.
Adv Pharm Bull. 2023 Jul;13(3):583-591. doi: 10.34172/apb.2023.063. Epub 2022 Dec 6.
Adv Pharm Bull. 2023.
PMID: 37646048
Free PMC article.
METHODS: The study was approached by designing three different analogs of Aur, including (a) Aur mutant (Aur(m)), (b) Aur with N-terminal polyarginine linker (R5-Aur), and (c) Aur(m) with R5 (R5-Aur(m)). Computational molecular dynamics simulations clearly sh …
METHODS: The study was approached by designing three different analogs of Aur, including (a) Aur mutant (Aur(m)), (b) Aur with N-term …