Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1999 2
2002 1
2009 2
2011 1
2015 1
2016 1
2017 4
2019 1
2020 6
2021 4
2022 1
2023 3
2024 2
2025 2
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

29 results

Results by year

Filters applied: . Clear all
Page 1
Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential.
Khoumeri O, Hutter S, Primas N, Castera-Ducros C, Carvalho S, Wyllie S, Efrit ML, Fayolle D, Since M, Vanelle P, Verhaeghe P, Azas N, El-Kashef H. Khoumeri O, et al. Pharmaceuticals (Basel). 2024 Jul 3;17(7):878. doi: 10.3390/ph17070878. Pharmaceuticals (Basel). 2024. PMID: 39065730 Free PMC article.
Thus, among the tested series, compound 14c appeared as a hit compound with good antileishmanial activity (EC(50) = 7 M) and low cytotoxicity against both the hepatic HepG2 and macrophage THP-1 human cell lines (CC(50) = 101 and 121 M, respectively), leading to good …
Thus, among the tested series, compound 14c appeared as a hit compound with good antileishmanial activity (EC(50) = 7 M) and low cyto …
Indole Diketopiperazine Alkaloids from the Marine Sediment-Derived Fungus Aspergillus chevalieri against Pancreatic Ductal Adenocarcinoma.
El-Kashef DH, Obidake DD, Schiedlauske K, Deipenbrock A, Scharf S, Wang H, Naumann D, Friedrich D, Miljanovic S, Haj Hassani Sohi T, Janiak C, Pfeffer K, Teusch N. El-Kashef DH, et al. Mar Drugs. 2023 Dec 20;22(1):5. doi: 10.3390/md22010005. Mar Drugs. 2023. PMID: 38276643 Free PMC article.
A new prenylated indole diketopiperazine alkaloid, rubrumline P (1), was isolated along with six more analogues and characterized from the fermentation culture of a marine sediment-derived fungus, Aspergillus chevalieri, collected at a depth of 15 m near the lighthouse in …
A new prenylated indole diketopiperazine alkaloid, rubrumline P (1), was isolated along with six more analogues and characterized from the f …
Polyketides and a Dihydroquinolone Alkaloid from a Marine-Derived Strain of the Fungus Metarhizium marquandii.
El-Kashef DH, Daletos G, Plenker M, Hartmann R, Mándi A, Kurtán T, Weber H, Lin W, Ancheeva E, Proksch P. El-Kashef DH, et al. J Nat Prod. 2019 Sep 27;82(9):2460-2469. doi: 10.1021/acs.jnatprod.9b00125. Epub 2019 Aug 21. J Nat Prod. 2019. PMID: 31432669
The (3R,4R) absolute configuration of aflaquinolone I (3), determined by OR, ECD, and VCD calculations, was found to be opposite of the (3S,4S) absolute configuration of the related aflaquinolones A-G, suggesting that the fungus M. marquandii produces aflaquinolone I with …
The (3R,4R) absolute configuration of aflaquinolone I (3), determined by OR, ECD, and VCD calculations, was found to be opposite of the (3S, …
Synthesis of a novel series of (Z)-3,5-disubstituted thiazolidine-2,4-diones as promising anti-breast cancer agents.
El-Kashef H, Badr G, Abo El-Maali N, Sayed D, Melnyk P, Lebegue N, Abd El-Khalek R. El-Kashef H, et al. Bioorg Chem. 2020 Mar;96:103569. doi: 10.1016/j.bioorg.2020.103569. Epub 2020 Jan 15. Bioorg Chem. 2020. PMID: 31978680
Using MTT uptake method, these three compounds 5, 7, and 9 blunt the proliferation of these cancer cells in a dose-dependent manner with an IC(50) of 1.27, 1.50 and 1.31 M respectively. Interestingly, using flow cytometry analysis these three compounds significantly mediat …
Using MTT uptake method, these three compounds 5, 7, and 9 blunt the proliferation of these cancer cells in a dose-dependent manner with an …
Polyketides from the marine-derived fungus Aspergillus falconensis: In silico and in vitro cytotoxicity studies.
El-Kashef DH, Youssef FS, Reimche I, Teusch N, Müller WEG, Lin W, Frank M, Liu Z, Proksch P. El-Kashef DH, et al. Bioorg Med Chem. 2021 Jan 1;29:115883. doi: 10.1016/j.bmc.2020.115883. Epub 2020 Nov 21. Bioorg Med Chem. 2021. PMID: 33248353
In vitro cytotoxic assessment using MTT assay showed that sulochrin (9) exhibited cytotoxic activity versus L5178Y mouse lymphoma cells with an IC(50) value of 5.1 M and inhibition of migration of MDA-MB 231 breast cancer cells at a concentration of 70 M....
In vitro cytotoxic assessment using MTT assay showed that sulochrin (9) exhibited cytotoxic activity versus L5178Y mouse lymphoma cells with …
Azaphilones from the Red Sea Fungus Aspergillus falconensis.
El-Kashef DH, Youssef FS, Hartmann R, Knedel TO, Janiak C, Lin W, Reimche I, Teusch N, Liu Z, Proksch P. El-Kashef DH, et al. Mar Drugs. 2020 Apr 10;18(4):204. doi: 10.3390/md18040204. Mar Drugs. 2020. PMID: 32290208 Free PMC article.
Compounds 1, 3-9, and 11 showed NF-kappaB inhibitory activity against the triple negative breast cancer cell line MDA-MB-231 with IC(50) values ranging from 11.9 to 72.0 M....
Compounds 1, 3-9, and 11 showed NF-kappaB inhibitory activity against the triple negative breast cancer cell line MDA-MB-231 with IC(50) val …
Febuxostat attenuates vascular calcification induced by vitamin D3 plus nicotine in rats.
Amer AE, El-Sheakh AR, Hamed MF, El-Kashef HA, Nader MA, Shehatou GSG. Amer AE, et al. Eur J Pharm Sci. 2021 Jan 1;156:105580. doi: 10.1016/j.ejps.2020.105580. Epub 2020 Sep 30. Eur J Pharm Sci. 2021. PMID: 33010420
VDN rats received a single dose of vitamin D3 (300.000 IU/kg, I.M) and two oral doses of nicotine (25 mg/kg) on day 1. They were then administrated FEB, in two doses (10 and 15 mg/kg/day, orally), or the drug vehicle, for 4 weeks. ...
VDN rats received a single dose of vitamin D3 (300.000 IU/kg, I.M) and two oral doses of nicotine (25 mg/kg) on day 1. They were then …
Production and optimization of novel Sphorolipids from Candida parapsilosis grown on potato peel and frying oil wastes and their adverse effect on Mucorales fungal strains.
Al-Kashef AS, Nooman MU, Rashad MM, Hashem AH, Abdelraof M. Al-Kashef AS, et al. Microb Cell Fact. 2023 Apr 25;22(1):79. doi: 10.1186/s12934-023-02088-0. Microb Cell Fact. 2023. PMID: 37095542 Free PMC article.
The SLs production was optimized utilizing Box-Behnken design resulting in the amelioration of yield by 30% (55.3 g/100 g substrate) and ST by 20.8% (38mN/m) with constant level of the critical micelle concentration (CMC) at 125 mg/L. The studies also revealed the high aff …
The SLs production was optimized utilizing Box-Behnken design resulting in the amelioration of yield by 30% (55.3 g/100 g substrate) and ST …
Sophorolipids produced by Yarrowia lipolytica grown on Moringa oleifera oil cake protect against acetic acid-induced colitis in rats: impact on TLR-4/p-JNK/NFκB-p65 pathway.
Nooman MU, Al-Kashef AS, Rashad MM, Khattab AEA, Ahmed KA, Abbas SS. Nooman MU, et al. J Pharm Pharmacol. 2023 Apr 7;75(4):544-558. doi: 10.1093/jpp/rgac101. J Pharm Pharmacol. 2023. PMID: 36680771
CONCLUSIONS: This study provided a novel impact for SLs produced by microbial conversion of M. oleifera oil cake against AA-induced UC in rats through hampering the TLR-4/p-JNK/NFkappaB-p65 signalling pathway....
CONCLUSIONS: This study provided a novel impact for SLs produced by microbial conversion of M. oleifera oil cake against AA-induced U …
29 results