Targeting DNA repair pathways with B02 and Nocodazole small molecules to improve CRIS-PITCh mediated cassette integration in CHO-K1 cells.
Rahmani B, Kheirandish MH, Ghanbari S, Raz A, Shamsi F, Davami F.
Rahmani B, et al.
Sci Rep. 2023 Feb 22;13(1):3116. doi: 10.1038/s41598-023-29863-8.
Sci Rep. 2023.
PMID: 36813818
Free PMC article.
Two small molecules, B02, a Rad51 inhibitor, and Nocodazole, a G2/M cell cycle synchronizer, were used to target the S100A hotspot site using a bxb1 recombinase comprised landing pad in CHO-K1 cells. ...
Two small molecules, B02, a Rad51 inhibitor, and Nocodazole, a G2/M cell cycle synchronizer, were used to target the S100A hotspot si …