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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1902 1
1903 1
1964 1
1971 1
1975 2
1976 1
1977 2
1978 1
1981 2
1983 1
1984 2
1985 1
1986 1
1987 3
1988 5
1989 4
1990 3
1991 3
1992 5
1993 5
1994 4
1995 5
1996 3
1997 1
1998 10
1999 10
2000 9
2001 10
2002 12
2003 7
2004 12
2005 16
2006 22
2007 22
2008 26
2009 46
2010 55
2011 102
2012 139
2013 213
2014 277
2015 368
2016 351
2017 385
2018 499
2019 514
2020 551
2021 662
2022 571
2023 538
2024 165

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5,020 results

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Page 1
METTL14-mediated m(6)A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis.
Fan HN, Chen ZY, Chen XY, Chen M, Yi YC, Zhu JS, Zhang J. Fan HN, et al. Mol Cancer. 2022 Feb 14;21(1):51. doi: 10.1186/s12943-022-01521-z. Mol Cancer. 2022. PMID: 35164771 Free PMC article.
Silencing of METTL14 reduced the m(6)A level of circORC5, but increased circORC5 expression. Moreover, circORC5 could sponge miR-30c-2-3p, and reverse METTL14-caused upregulation of miR-30c-2-3p and downregulation of AKT1S1 and EIF4B. In addition, circORC5 po …
Silencing of METTL14 reduced the m(6)A level of circORC5, but increased circORC5 expression. Moreover, circORC5 could sponge miR
CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma.
Liu L, Gu M, Ma J, Wang Y, Li M, Wang H, Yin X, Li X. Liu L, et al. Mol Cancer. 2022 Jul 20;21(1):149. doi: 10.1186/s12943-022-01619-4. Mol Cancer. 2022. PMID: 35858900 Free PMC article.
The role of circGPR137B in HCC was estimated in vitro and in vivo. RT-qPCR, western blot, m(6)A dot blot, RIP, MeRIP and dual-luciferase reporter assays were used to validate the reciprocal regulation of the feedback loop among circGPR137B, miR-4739 and m(6)A …
The role of circGPR137B in HCC was estimated in vitro and in vivo. RT-qPCR, western blot, m(6)A dot blot, RIP, MeRIP and dual-lucifer …
m(6)A modification of circSPECC1 suppresses RPE oxidative damage and maintains retinal homeostasis.
Chen X, Wang Y, Wang JN, Cao QC, Sun RX, Zhu HJ, Zhang YR, Ji JD, Liu QH. Chen X, et al. Cell Rep. 2022 Nov 15;41(7):111671. doi: 10.1016/j.celrep.2022.111671. Cell Rep. 2022. PMID: 36384115 Free article.
Mechanically, nuclear export of circSPECC1 transcript depends on its N(6)-methyladenosine (m(6)A) level with YTHDC1 as the reader. CircSPECC1 directly sponges miR-145-5p to block its interaction with CDKN1A. ...Collectively, circSPECC1, mediated by m(6)A modi …
Mechanically, nuclear export of circSPECC1 transcript depends on its N(6)-methyladenosine (m(6)A) level with YTHDC1 as the reader. Ci …
Macrophage-derived exosomes modulate wear particle-induced osteolysis via miR-3470b targeting TAB3/NF-kappaB signaling.
Pan B, Zhang Z, Wu X, Xian G, Hu X, Gu M, Zheng L, Li X, Long L, Chen W, Sheng P. Pan B, et al. Bioact Mater. 2023 Mar 3;26:181-193. doi: 10.1016/j.bioactmat.2023.02.028. eCollection 2023 Aug. Bioact Mater. 2023. PMID: 36911207 Free PMC article.
The results of exosomes up-taken experiments revealed that osteoblast and mature osteoclasts capture macrophage-derived exosomes (M-Exo). Next-generation sequencing and RT-qPCR on M-Exo revealed that exosomal microRNA miR-3470b was downregulated in wear parti …
The results of exosomes up-taken experiments revealed that osteoblast and mature osteoclasts capture macrophage-derived exosomes (M-E …
miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages.
Nguyen MA, Hoang HD, Rasheed A, Duchez AC, Wyatt H, Cottee ML, Graber TE, Susser L, Robichaud S, Berber İ, Geoffrion M, Ouimet M, Kazan H, Maegdefessel L, Mulvihill EE, Alain T, Rayner KJ. Nguyen MA, et al. Circ Res. 2022 Jun 24;131(1):42-58. doi: 10.1161/CIRCRESAHA.121.319120. Epub 2022 May 25. Circ Res. 2022. PMID: 35611698 Free PMC article.
These beneficial effects of miR-223 are dependent on its target gene, the transcription factor Sp3. ...Analysis of upregulated genes at the translation level reveal an enrichment of miR-223-binding sites, confirming that miR-223 exerts significant changes in …
These beneficial effects of miR-223 are dependent on its target gene, the transcription factor Sp3. ...Analysis of upregulated genes …
MiR-155 regulates m(6)A level and cell progression by targeting FTO in clear cell renal cell carcinoma.
Yang W, Xie L, Wang P, Zhuang C. Yang W, et al. Cell Signal. 2022 Mar;91:110217. doi: 10.1016/j.cellsig.2021.110217. Epub 2021 Dec 16. Cell Signal. 2022. PMID: 34921979
Here we show that miR-155 directly targets FTO to negatively regulate its expression and increased m(6)A level in ccRCC. ...Moreover, cell function assays, xenografts assays and m(6)A dot blot assays revealed that overexpression of miR-155 enhanced tum …
Here we show that miR-155 directly targets FTO to negatively regulate its expression and increased m(6)A level in ccRCC. ...Mo …
M(7)G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma.
He M, Wang Y, Xie J, Pu J, Shen Z, Wang A, Li T, Wang T, Li G, Liu Y, Mei Z, Ren Z, Wang W, Liu X, Hong J, Liu Q, Lei H, He X, Du W, Yuan Y, Yang L. He M, et al. Oncogene. 2024 Jan;43(5):341-353. doi: 10.1038/s41388-023-02882-5. Epub 2023 Dec 1. Oncogene. 2024. PMID: 38040806
Interestingly, METTL1 significantly increased the expression of FTH1 at the mRNA level but was remarkably suppressed at the protein level. We then identified primary (pri)-miR-26a and pri-miR-98 in the Top 20 m(7)G-methylated pri-miRNAs with highly conserved …
Interestingly, METTL1 significantly increased the expression of FTH1 at the mRNA level but was remarkably suppressed at the protein level. W …
As3MT via consuming SAM is involved in arsenic-induced nonalcoholic fatty liver disease by blocking m(6)A-mediated miR-142-5p maturation.
Li H, Wu L, Ye F, Wang D, Wang L, Li W, Xu Y, Li Z, Zhang J, Wang S, Zhang A, Liu Q. Li H, et al. Sci Total Environ. 2023 Sep 20;892:164746. doi: 10.1016/j.scitotenv.2023.164746. Epub 2023 Jun 8. Sci Total Environ. 2023. PMID: 37301390
Here, we found that chronic exposure to environmental-related doses of arsenic disturbed fatty acid and methionine metabolism in mice, caused liver steatosis, increased arsenic (3) methyltransferase (As3MT), sterol regulatory element binding protein 1 (SREBP1) and lipogenic gene …
Here, we found that chronic exposure to environmental-related doses of arsenic disturbed fatty acid and methionine metabolism in mice, cause …
WTAP-mediated m(6)A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis.
You Y, Liu J, Zhang L, Li X, Sun Z, Dai Z, Ma J, Jiao G, Chen Y. You Y, et al. Cell Death Dis. 2023 Jan 17;14(1):33. doi: 10.1038/s41419-023-05565-x. Cell Death Dis. 2023. PMID: 36650131 Free PMC article.
Mechanistically, the expression of WTAP increased during osteogenic differentiation and significantly promoted pri-miR-181a and pri-miR-181c methylation, which was recognized by YTHDC1, and increased the maturation to miR-181a and miR-181c. MiR- …
Mechanistically, the expression of WTAP increased during osteogenic differentiation and significantly promoted pri-miR-181a and pri- …
RNA m(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression.
Zhang Z, Zhou K, Han L, Small A, Xue J, Huang H, Weng H, Su R, Tan B, Shen C, Li W, Zhao Z, Qing Y, Qin X, Wang K, Leung K, Boldin M, Chen CW, Ann D, Qian Z, Deng X, Chen J, Chen Z. Zhang Z, et al. Genes Dis. 2023 Mar 28;11(1):382-396. doi: 10.1016/j.gendis.2023.01.016. eCollection 2024 Jan. Genes Dis. 2023. PMID: 37588203 Free PMC article.
Here, we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia (AML) patients, especially in relapsed patients, and plays an oncogenic role in AML. Moreover, YTHDF2 promotes expression of miR-126-3p (also known as miR-126, as it is the main product …
Here, we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia (AML) patients, especially in relapsed patients, and plays …
5,020 results