In vitro and in vivo evaluation of the mechanisms of citalopram-induced hepatotoxicity.
Ahmadian E, Eftekhari A, Fard JK, Babaei H, Nayebi AM, Mohammadnejad D, Eghbal MA.
Ahmadian E, et al.
Arch Pharm Res. 2017 Nov;40(11):1296-1313. doi: 10.1007/s12272-016-0766-0. Epub 2016 Jun 6.
Arch Pharm Res. 2017.
PMID: 27271269
In the in vitro experiments, citalopram (500 M) exposure demonstrated cell death, a marked elevation in ROS formation, mitochondrial potential collapse, lysosomal membrane leakiness, glutathione (GSH) depletion and lipid peroxidation. ...
In the in vitro experiments, citalopram (500 M) exposure demonstrated cell death, a marked elevation in ROS formation, mitochondrial …