Ibrutinib and rituximab versus immunochemotherapy in patients with previously untreated mantle cell lymphoma (ENRICH): a randomised, open-label, phase 2/3 superiority trial.
Lewis DJ, Jerkeman M, Sorrell L, Wright D, Glimelius I, Poulsen CB, Pasanen A, Rawstron A, Wader KF, Morley N, Burton C, Davies AJ, Lagerlöf I, Dalal S, De Tute R, McNamara C, Crosbie N, Toldbod HE, Sanders J, Allgar V, Aroori S, Warner M, Scully C, Wainman B, Christensen JH, Riise J, Sonnevi K, Bishton MJ, Eyre TA, Rule S; ENRICH investigators.
Lewis DJ, et al.
Lancet. 2025 Oct 25;406(10514):1953-1968. doi: 10.1016/S0140-6736(25)01432-1. Epub 2025 Oct 3.
Lancet. 2025.
PMID: 41052510
Free PMC article.
Clinical Trial.
R-CHOP comprised 750 mg/m(2) of cyclophosphamide, 50 mg/m(2) of doxorubicin, and 1.4 mg/m(2) vincristine on day 1 of each 21-day cycle, with 100 mg prednisolone on days 1-5 of each cycle. Rituximab-bendamustine comprised 90 mg/m(2) of bendamustine on d …
R-CHOP comprised 750 mg/m(2) of cyclophosphamide, 50 mg/m(2) of doxorubicin, and 1.4 mg/m(2) vincristine on day 1 of ea …