A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer.
Somarelli JA, Roghani RS, Moghaddam AS, Thomas BC, Rupprecht G, Ware KE, Altunel E, Mantyh JB, Kim SY, McCall SJ, Shen X, Mantyh CR, Hsu DS.
Somarelli JA, et al.
Mol Cancer Ther. 2020 Dec;19(12):2516-2527. doi: 10.1158/1535-7163.MCT-20-0454. Epub 2020 Nov 6.
Mol Cancer Ther. 2020.
PMID: 33158998
Free PMC article.
Mechanistically, dual CDK2/9 inhibition induced significant G(2)-M arrest and anaphase catastrophe. Combined CDK2/9 inhibition in vivo synergistically reduced PDX tumor growth. ...
Mechanistically, dual CDK2/9 inhibition induced significant G(2)-M arrest and anaphase catastrophe. Combined CDK2/9 inhibition in viv …