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Page 1
Mitochondria-Targeted Polyamidoamine Dendrimer-Curcumin Construct for Hepatocellular Cancer Treatment.
Kianamiri S, Dinari A, Sadeghizadeh M, Rezaei M, Daraei B, Bahsoun NE, Nomani A. Kianamiri S, et al. Mol Pharm. 2020 Dec 7;17(12):4483-4498. doi: 10.1021/acs.molpharmaceut.0c00566. Epub 2020 Nov 18. Mol Pharm. 2020. PMID: 33205974
Our findings showed that the targeted-dendrimeric curcumin (TDC) could successfully deliver and colocalize the drug to the mitochondria of the cancer cells, and selectively induce a potent apoptosis and cell cycle arrest at G2/M. Moreover, at a low curcumin dose of less th …
Our findings showed that the targeted-dendrimeric curcumin (TDC) could successfully deliver and colocalize the drug to the mitochondria of t …
Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells.
Varnamkhasti TJ, Jafarzadeh M, Sadeghizadeh M, Aghili M. Varnamkhasti TJ, et al. Pharmacol Rep. 2022 Aug;74(4):718-735. doi: 10.1007/s43440-022-00383-y. Epub 2022 Jul 10. Pharmacol Rep. 2022. PMID: 35819593
Further experiments then indicated that DNC could effectively induce G2/M phase cell cycle arrest and apoptosis following irradiation. ...
Further experiments then indicated that DNC could effectively induce G2/M phase cell cycle arrest and apoptosis following irradiation …
Down-regulation of lncRNA, GAS5 decreases chemotherapeutic effect of dendrosomal curcumin (DNC) in breast cancer cells.
Esmatabadi MJD, Motamedrad M, Sadeghizadeh M. Esmatabadi MJD, et al. Phytomedicine. 2018 Mar 15;42:56-65. doi: 10.1016/j.phymed.2018.03.022. Epub 2018 Mar 13. Phytomedicine. 2018. PMID: 29655698
Furthermore, DNC induced a significant increase in the number of cells in sub G1/G1 phase and a decrease in the G2/M phase of the cell cycle. But, after GAS5 down-regulation alone opposite results was observed compared to DNC. ...
Furthermore, DNC induced a significant increase in the number of cells in sub G1/G1 phase and a decrease in the G2/M phase of the cel …
Antiproliferative and Apoptotic Effect of Dendrosomal Curcumin Nanoformulation in P53 Mutant and Wide-Type Cancer Cell Lines.
Montazeri M, Pilehvar-Soltanahmadi Y, Mohaghegh M, Panahi A, Khodi S, Zarghami N, Sadeghizadeh M. Montazeri M, et al. Anticancer Agents Med Chem. 2017;17(5):662-673. doi: 10.2174/1871520616666160815124537. Anticancer Agents Med Chem. 2017. PMID: 27604683
RESULTS: During the time, DNC increased the SubG1 cells and decreased G1, S and G2/M cells, early apoptosis also indicated the inhibition of cell growth in early phase. ...
RESULTS: During the time, DNC increased the SubG1 cells and decreased G1, S and G2/M cells, early apoptosis also indicated the inhibi …
Nanoformulation of curcumin protects HUVEC endothelial cells against ionizing radiation and suppresses their adhesion to monocytes: potential in prevention of radiation-induced atherosclerosis.
Soltani B, Bodaghabadi N, Mahpour G, Ghaemi N, Sadeghizadeh M. Soltani B, et al. Biotechnol Lett. 2016 Dec;38(12):2081-2088. doi: 10.1007/s10529-016-2189-x. Epub 2016 Aug 24. Biotechnol Lett. 2016. PMID: 27558390
RESULTS: Co(60) gamma rays reduced viability, raised the expression of adhesion molecules, ICAM-1, VCAM-1 and E-selectin (mRNA and protein), augmented the adhesion of THP-1 cells to HUVECs, activated NF-kappaB binding, increased the release of pro-inflammatory cytokines (IL-6, IL …
RESULTS: Co(60) gamma rays reduced viability, raised the expression of adhesion molecules, ICAM-1, VCAM-1 and E-selectin (mRNA and protein), …
Cancer-associated fibroblasts enhance cell proliferation and metastasis of colorectal cancer SW480 cells by provoking long noncoding RNA UCA1.
Jahangiri B, Khalaj-Kondori M, Asadollahi E, Sadeghizadeh M. Jahangiri B, et al. J Cell Commun Signal. 2019 Mar;13(1):53-64. doi: 10.1007/s12079-018-0471-5. Epub 2018 Jun 11. J Cell Commun Signal. 2019. PMID: 29948578 Free PMC article.
Moreover, we found an increased percentage of CRC cell in the S and G2/M phase induced by CAFs. Our results revealed that CAFs could induce upregulation of UCA1, leading to upregulation of mTOR. ...
Moreover, we found an increased percentage of CRC cell in the S and G2/M phase induced by CAFs. Our results revealed that CAFs could …
19 results