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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1975 2
1976 1
1977 7
1978 2
1979 1
1980 2
1981 4
1982 4
1983 2
1984 6
1985 5
1986 5
1987 5
1988 5
1989 8
1990 6
1991 9
1992 12
1993 15
1994 12
1995 16
1996 15
1997 16
1998 20
1999 22
2000 12
2001 28
2002 19
2003 28
2004 28
2005 25
2006 21
2007 26
2008 19
2009 22
2010 26
2011 33
2012 46
2013 40
2014 24
2015 43
2016 48
2017 49
2018 60
2019 97
2020 98
2021 107
2022 121
2023 114
2024 140
2025 146
2026 34

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1,502 results

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Page 1
A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease.
Fonseca-Gomes J, Costa-Coelho T, Ferreira-Manso M, Inteiro-Oliveira S, Vaz SH, Alemãn-Serrano N, Atalaia-Barbacena H, Ribeiro-Rodrigues L, Ramalho RM, Pinto R, Vicente Miranda H, Tanqueiro SR, de Almeida-Borlido C, Ramalho MJ, Miranda-Lourenço C, Belo RF, Ferreira CB, Neves V, Rombo DM, Viais R, Umemori J, Martins IC, Jerónimo-Santos A, Caetano A, Manso N, Mäkinen P, Marttinen M, Takalo M, Bremang M, Pike I, Haapasalo A, Loureiro JA, Pereira MC, Santos NC, Outeiro TF, Castanho MARB, Fernandes A, Hiltunen M, Duarte CB, Castrén E, de Mendonça A, Sebastião AM, Rodrigues TM, Diógenes MJ. Fonseca-Gomes J, et al. Mol Ther. 2024 Oct 2;32(10):3372-3401. doi: 10.1016/j.ymthe.2024.08.022. Epub 2024 Aug 27. Mol Ther. 2024. PMID: 39205389 Free PMC article.
To explore the therapeutic potential of this disease mechanism, we designed small TAT-fused peptides and screened their ability to prevent TrkB-FL receptor cleavage. Among these, a TAT-TrkB peptide with a lysine-lysine linker prevented TrkB-FL cleavage both in vitro …
To explore the therapeutic potential of this disease mechanism, we designed small TAT-fused peptides and screened their ability to pr …
Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir.
Pardons M, Cole B, Lambrechts L, van Snippenberg W, Rutsaert S, Noppe Y, De Langhe N, Dhondt A, Vega J, Eyassu F, Nijs E, Van Gulck E, Boden D, Vandekerckhove L. Pardons M, et al. Nat Commun. 2023 Dec 18;14(1):8397. doi: 10.1038/s41467-023-44020-5. Nat Commun. 2023. PMID: 38110433 Free PMC article.
Here, we explore the reactivation capacity of a lipid nanoparticle containing Tat mRNA (Tat-LNP) in CD4 T cells from people living with HIV undergoing antiretroviral therapy (ART). ...We demonstrate that Tat-LNP does not alter the transcriptome of CD4 T cells …
Here, we explore the reactivation capacity of a lipid nanoparticle containing Tat mRNA (Tat-LNP) in CD4 T cells from people li …
Efficient mRNA delivery to resting T cells to reverse HIV latency.
Cevaal PM, Kan S, Fisher BM, Moso MA, Tan A, Liu H, Ali A, Tanaka K, Shepherd RA, Kim Y, Ong J, Furtado DL, Holz M, Purcell DFJ, Casan JML, Payne T, Zhao W, Fareh M, McMahon JH, Deeks SG, Hoh R, Telwatte S, Pouton CW, Johnston APR, Caruso F, Symons J, Lewin SR, Roche M. Cevaal PM, et al. Nat Commun. 2025 May 29;16(1):4979. doi: 10.1038/s41467-025-60001-2. Nat Commun. 2025. PMID: 40442114 Free PMC article.
Here we develop an LNP formulation (LNP X) with unprecedented potency to deliver mRNA to hard-to-transfect resting CD4(+) T cells in the absence of cellular toxicity or activation. Encapsulating an mRNA encoding the HIV Tat protein, an activator of HIV transcription, LNP X …
Here we develop an LNP formulation (LNP X) with unprecedented potency to deliver mRNA to hard-to-transfect resting CD4(+) T cells in the abs …
HIV-1 Tat protein enhances RANKL/M-CSF-mediated osteoclast differentiation.
Gibellini D, De Crignis E, Ponti C, Borderi M, Clò A, Miserocchi A, Viale P, Re MC. Gibellini D, et al. Biochem Biophys Res Commun. 2010 Oct 22;401(3):429-34. doi: 10.1016/j.bbrc.2010.09.071. Epub 2010 Sep 24. Biochem Biophys Res Commun. 2010. PMID: 20869948
This study analyzed the biological effects of Tat on peripheral blood monocyte-derived osteoclast differentiation. Tat enhances osteoclast differentiation and activity induced by RANKL plus M-CSF treatment increasing both the mRNA expression of specific osteo …
This study analyzed the biological effects of Tat on peripheral blood monocyte-derived osteoclast differentiation. Tat enhance …
Novel Tat-Dependent Protein Secretion.
Braun V, Hantke K. Braun V, et al. J Bacteriol. 2020 Apr 9;202(9):e00058-20. doi: 10.1128/JB.00058-20. Print 2020 Apr 9. J Bacteriol. 2020. PMID: 32015148 Free PMC article.
In this issue of Journal of Bacteriology, I. J. Passmore, J. M. Dow, F. Coll, J. Cuccui, et al. (J Bacteriol 202:e00541-19, 2020, https://doi.org/10.1128/JB.00541-19) report that the FecR sequence contains both the twin-arginine signal motif and the secretory (Sec) avoidan …
In this issue of Journal of Bacteriology, I. J. Passmore, J. M. Dow, F. Coll, J. Cuccui, et al. (J Bacteriol 202:e00541-19, 2020, htt …
EGFR amplification and EGFRvIII predict and participate in TAT-Cx43266-283 antitumor response in preclinical glioblastoma models.
Álvarez-Vázquez A, San-Segundo L, Cerveró-García P, Flores-Hernández R, Ollauri-Ibáñez C, Segura-Collar B, Hubert CG, Morrison G, Pollard SM, Lathia JD, Sánchez-Gómez P, Tabernero A. Álvarez-Vázquez A, et al. Neuro Oncol. 2024 Jul 5;26(7):1230-1246. doi: 10.1093/neuonc/noae060. Neuro Oncol. 2024. PMID: 38507464 Free PMC article.
Given the link between EGFR and Src, the aim of this study was to explore the role of EGFR in the antitumor effects of TAT-Cx43266-283. METHODS: The effect of TAT-Cx43266-283, temozolomide (TMZ), and erlotinib (EGFR inhibitor) was studied in patient-derived GBM stem …
Given the link between EGFR and Src, the aim of this study was to explore the role of EGFR in the antitumor effects of TAT-Cx43266-28 …
Targeting Tat-TAR RNA Interaction for HIV-1 Inhibition.
Alanazi A, Ivanov A, Kumari N, Lin X, Wang S, Kovalskyy D, Nekhai S. Alanazi A, et al. Viruses. 2021 Oct 6;13(10):2004. doi: 10.3390/v13102004. Viruses. 2021. PMID: 34696435 Free PMC article.
Only the T0516-4834 compound showed selective inhibition of Tat-induced HIV-1 transcription, whereas the T6780107 compound inhibited equally basal and Tat-induced transcription and the T5628834 compound only inhibited basal HIV-1 transcription. ...Of the three compo …
Only the T0516-4834 compound showed selective inhibition of Tat-induced HIV-1 transcription, whereas the T6780107 compound inhibited …
Erratum: "Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients". Kiki Waeijen-Smit, Mieke Crutsen, Spencer Keene, Marc Miravitlles, Ernesto Crisafulli, Antoni Torres, Christian Mueller, Philipp Schuetz, Thomas J. Ringbaek, Fabio Fabbian, Evgeni Mekov, Timothy H. Harries, Chung-tat Lun, Begum Ergan, Cristobal Esteban, Jose M. Quintana Lopez, Jose Luis Lopez-Campos, Catherina L. Chang, Robert J. Hancox, Eskandarain Shafuddin, Hollie Ellis, Christer Janson, Charlotte Suppli Ulrik, Gunnar Gudmundsson, Danny Epstein, Jose Dominguez, Alicia Lacoma, Christian Osadnik, Inmaculada Alia, Francesco Spannella, Zuhal Karakurt, Hossein Mehravaran, Cecile Utens, Martijn D. de Kruif, Fanny Wai San Ko, Samuel P. Trethewey, Alice M. Turner, Dragos Bumbacea, Patrick B. Murphy, Kristina Vermeersch, Shani Zilberman-Itskovich, John Steer, Carlos Echevarria, Stephen C. Bourke, Nicholas Lane, Jordi de Batlle, Roy T.M. Sprooten, Richard Russell, Paola Faverio, Jane L. Cross, Hendrik J. Prins, Martijn A. Spruit, Sami O. Simons, Sarah Houben-Wilke and Frits M.E. Franssen. ERJ Open Res 2024; 10: 00838-2023.
[No authors listed] [No authors listed] ERJ Open Res. 2024 Nov 25;10(6):50838-2023. doi: 10.1183/23120541.50838-2023. eCollection 2024 Nov. ERJ Open Res. 2024. PMID: 39588074 Free PMC article.
HIV-1 Tat protein inhibits the hematopoietic support function of human bone marrow mesenchymal stem cells.
Yuan Y, Zhou C, Yang Q, Ma S, Wang X, Guo X, Ding Y, Tang J, Zeng Y, Li D. Yuan Y, et al. Virus Res. 2019 Nov;273:197756. doi: 10.1016/j.virusres.2019.197756. Epub 2019 Sep 12. Virus Res. 2019. PMID: 31521762
BMSCs were treated with HIV-1 Tat protein (BMSC(Tat-p)), transfected with HIV-1 Tat mRNA (BMSC(Tat-m)) or treated with solvent (PBS) (BMSC(con)) for 20 days. ...In addition, the hematopoiesis-supporting gene expression patterns of BMSC(Tat …
BMSCs were treated with HIV-1 Tat protein (BMSC(Tat-p)), transfected with HIV-1 Tat mRNA (BMSC(Tat-m)) or …
Inhibition of HIV type 1 Tat-mediated trans-activation by oncostatin M in HLtat cells.
Esté JA, Witvrouw M, Tu J, Desmyter J, De Clercq E, Vandamme AM. Esté JA, et al. AIDS Res Hum Retroviruses. 1995 Nov;11(11):1355-8. doi: 10.1089/aid.1995.11.1355. AIDS Res Hum Retroviruses. 1995. PMID: 8573392
We have tested the effect of oncostatin M (OSM) on the Tat-mediated trans-activation in a HeLa cell line (HLtat) expressing Tat, using a transfection assay with the LacZ gene under the control of the HIV-1 LTR. ...Our findings with OSM indicate that, for the …
We have tested the effect of oncostatin M (OSM) on the Tat-mediated trans-activation in a HeLa cell line (HLtat) expressing …
1,502 results