Design, synthesis and biological evaluation of novel indanone containing spiroisoxazoline derivatives with selective COX-2 inhibition as anticancer agents.
Abolhasani H, Zarghi A, Komeili Movahhed T, Abolhasani A, Daraei B, Dastmalchi S.
Abolhasani H, et al.
Bioorg Med Chem. 2021 Feb 15;32:115960. doi: 10.1016/j.bmc.2020.115960. Epub 2021 Jan 2.
Bioorg Med Chem. 2021.
PMID: 33477020
Furthermore, compound 9f, which possesses 3,4-dimethoxyphenyl on C-3' carbon atom of isoxazoline ring, exhibited the highest COX-2 inhibitory activity, and also displayed the most potent cytotoxicity on MCF-7 cells with an IC(50) value of 0.03 0.01 M, comparable with that …
Furthermore, compound 9f, which possesses 3,4-dimethoxyphenyl on C-3' carbon atom of isoxazoline ring, exhibited the highest COX-2 inhibitor …