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Year Number of Results
1971 1
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1973 1
1977 1
1979 2
1980 6
1981 8
1982 22
1983 27
1984 33
1985 31
1986 56
1987 48
1988 66
1989 80
1990 65
1991 73
1992 123
1993 135
1994 170
1995 209
1996 213
1997 220
1998 239
1999 325
2000 284
2001 294
2002 296
2003 345
2004 357
2005 405
2006 448
2007 410
2008 425
2009 465
2010 456
2011 458
2012 441
2013 461
2014 489
2015 502
2016 412
2017 381
2018 372
2019 378
2020 349
2021 313
2022 234
2023 216
2024 250
2025 253

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11,177 results

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Page 1
Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases.
Kampmann M. Kampmann M. Nat Rev Neurosci. 2024 May;25(5):351-371. doi: 10.1038/s41583-024-00806-0. Epub 2024 Apr 4. Nat Rev Neurosci. 2024. PMID: 38575768 Review.
I highlight how recent methodological innovations - including single-cell transcriptomics, CRISPR-based screens and human cell-based models of disease - are enabling new breakthroughs in our understanding of selective vulnerability. An understanding of the molecular mechan …
I highlight how recent methodological innovations - including single-cell transcriptomics, CRISPR-based screens and human cell-based models …
Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential.
Inoue K, Tsuda M. Inoue K, et al. Nat Rev Neurosci. 2018 Mar;19(3):138-152. doi: 10.1038/nrn.2018.2. Epub 2018 Feb 8. Nat Rev Neurosci. 2018. PMID: 29416128 Review.
Over recent decades, studies have provided evidence for the necessity and sufficiency of microglia for the alterations in synaptic remodelling, connectivity and network function that underlie chronic pain and have shed light on the underlying molecular and cellular …
Over recent decades, studies have provided evidence for the necessity and sufficiency of microglia for the alterations in synaptic remodelli …
Breathing matters.
Del Negro CA, Funk GD, Feldman JL. Del Negro CA, et al. Nat Rev Neurosci. 2018 Jun;19(6):351-367. doi: 10.1038/s41583-018-0003-6. Nat Rev Neurosci. 2018. PMID: 29740175 Free PMC article. Review.
Key neural elements for generating breathing pattern are distinct, compact and form a network amenable to detailed interrogation, promising the imminent discovery of molecular, cellular, synaptic and network mechanisms that give rise to the behaviour. Coupled oscill …
Key neural elements for generating breathing pattern are distinct, compact and form a network amenable to detailed interrogation, promising …
CaMKII: a central molecular organizer of synaptic plasticity, learning and memory.
Yasuda R, Hayashi Y, Hell JW. Yasuda R, et al. Nat Rev Neurosci. 2022 Nov;23(11):666-682. doi: 10.1038/s41583-022-00624-2. Epub 2022 Sep 2. Nat Rev Neurosci. 2022. PMID: 36056211 Review.
It is activated by intracellular increases in calcium ion levels and triggers molecular processes necessary for synaptic plasticity. CaMKII phosphorylates numerous synaptic proteins, thereby regulating their structure and functions. This leads to molecular events cr …
It is activated by intracellular increases in calcium ion levels and triggers molecular processes necessary for synaptic plasticity. …
The sympathetic nervous system in development and disease.
Scott-Solomon E, Boehm E, Kuruvilla R. Scott-Solomon E, et al. Nat Rev Neurosci. 2021 Nov;22(11):685-702. doi: 10.1038/s41583-021-00523-y. Epub 2021 Oct 1. Nat Rev Neurosci. 2021. PMID: 34599308 Free PMC article. Review.
Recent progress has also been made in identifying how the cellular and molecular diversity of sympathetic neurons is established to meet the functional demands of peripheral organs. ...
Recent progress has also been made in identifying how the cellular and molecular diversity of sympathetic neurons is establish …
Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders.
Brandebura AN, Paumier A, Onur TS, Allen NJ. Brandebura AN, et al. Nat Rev Neurosci. 2023 Jan;24(1):23-39. doi: 10.1038/s41583-022-00641-1. Epub 2022 Oct 31. Nat Rev Neurosci. 2023. PMID: 36316501 Free PMC article. Review.
There is increasing appreciation that non-neuronal cells contribute to the initiation, progression and pathology of diverse neurodegenerative disorders. ...Given the central role of astrocytes in neurodegenerative disorders, potential strategies to target these cells …
There is increasing appreciation that non-neuronal cells contribute to the initiation, progression and pathology of diverse neurodege …
Generation of circadian rhythms in the suprachiasmatic nucleus.
Hastings MH, Maywood ES, Brancaccio M. Hastings MH, et al. Nat Rev Neurosci. 2018 Aug;19(8):453-469. doi: 10.1038/s41583-018-0026-z. Nat Rev Neurosci. 2018. PMID: 29934559 Review.
However, the analysis of circadian time-keeping is moving beyond single cells. Technical and conceptual advances, including intersectional genetics, multidimensional imaging and network theory, are beginning to uncover the circuit-level mechanisms and emergent properties t …
However, the analysis of circadian time-keeping is moving beyond single cells. Technical and conceptual advances, including intersect …
Genomics, convergent neuroscience and progress in understanding autism spectrum disorder.
Willsey HR, Willsey AJ, Wang B, State MW. Willsey HR, et al. Nat Rev Neurosci. 2022 Jun;23(6):323-341. doi: 10.1038/s41583-022-00576-7. Epub 2022 Apr 19. Nat Rev Neurosci. 2022. PMID: 35440779 Free PMC article. Review.
These methods seek to identify intersection among molecular-level, cellular-level and circuit-level functions across multiple risk genes and have highlighted developing excitatory neurons in the human mid-gestational prefrontal cortex as an important pathobiological …
These methods seek to identify intersection among molecular-level, cellular-level and circuit-level functions across multiple …
Embracing diversity in the 5-HT neuronal system.
Okaty BW, Commons KG, Dymecki SM. Okaty BW, et al. Nat Rev Neurosci. 2019 Jul;20(7):397-424. doi: 10.1038/s41583-019-0151-3. Nat Rev Neurosci. 2019. PMID: 30948838 Review.
Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core set of genes that establish and maintain this neurotransmitter phenotype and distinguish these neurons from other brain cells. Beyond a shared 5-HTergic phenotype, these neurons displa …
Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core set of genes that establish and maintain this neuro …
Microglial signatures and their role in health and disease.
Butovsky O, Weiner HL. Butovsky O, et al. Nat Rev Neurosci. 2018 Oct;19(10):622-635. doi: 10.1038/s41583-018-0057-5. Nat Rev Neurosci. 2018. PMID: 30206328 Free PMC article. Review.
Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and surface protein expression pattern, which differs from that of tissue macrop …
Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a unique molecular homeostatic 's …
11,177 results
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