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Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2).
Machwate M, Harada S, Leu CT, Seedor G, Labelle M, Gallant M, Hutchins S, Lachance N, Sawyer N, Slipetz D, Metters KM, Rodan SB, Young R, Rodan GA. Machwate M, et al. Mol Pharmacol. 2001 Jul;60(1):36-41. doi: 10.1124/mol.60.1.36. Mol Pharmacol. 2001. PMID: 11408598
Prostaglandin E2 (PGE2) increases the number of rat bone marrow osteogenic stromal cells (BMSC) via binding the EP4 receptor, activating sphingosine kinase and inhibiting caspase activity.
Weinreb M, Shamir D, Machwate M, Rodan GA, Harada S, Keila S. Weinreb M, et al. Among authors: machwate m. Prostaglandins Leukot Essent Fatty Acids. 2006 Aug;75(2):81-90. doi: 10.1016/j.plefa.2006.06.004. Epub 2006 Aug 4. Prostaglandins Leukot Essent Fatty Acids. 2006. PMID: 16890416
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