Amino acyl conjugates of nitrogen heterocycles as potential pharmacophores

Alan R Katritzky; Kiran Bajaj; Mael Charpentier; Ebrahim Ghazvini Zadeh

doi:10.1021/jo100625y

Amino acyl conjugates of nitrogen heterocycles as potential pharmacophores

J Org Chem. 2010 Jun 4;75(11):3938-40. doi: 10.1021/jo100625y.

Authors

Alan R Katritzky¹, Kiran Bajaj, Mael Charpentier, Ebrahim Ghazvini Zadeh

Affiliation

¹ Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu

PMID: 20459134
DOI: 10.1021/jo100625y

Abstract

2-Methyl- and 4-methylpyridine and 2-methylquinoline are converted by benzotriazole-activated (Cbz)-protected amino acids into chiral potential novel pharmacophore aminoacyl conjugates (33-53%).

MeSH terms

Amino Acids / chemistry*
Heterocyclic Compounds / chemistry*
Nitrogen
Picolines / chemistry
Quinaldines / chemistry
Triazoles

Substances

Amino Acids
Heterocyclic Compounds
Picolines
Quinaldines
Triazoles
2-picoline
benzotriazole
2-methylquinoline
Nitrogen
4-methylpyridine