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The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide.
Rosato RR, Maggio SC, Almenara JA, Payne SG, Atadja P, Spiegel S, Dent P, Grant S. Rosato RR, et al. Among authors: maggio sc. Mol Pharmacol. 2006 Jan;69(1):216-25. doi: 10.1124/mol.105.017145. Epub 2005 Sep 27. Mol Pharmacol. 2006. PMID: 16189296 Retracted.