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In situ genome sequencing resolves DNA sequence and structure in intact biological samples.
Payne AC, Chiang ZD, Reginato PL, Mangiameli SM, Murray EM, Yao CC, Markoulaki S, Earl AS, Labade AS, Jaenisch R, Church GM, Boyden ES, Buenrostro JD, Chen F. Payne AC, et al. Among authors: mangiameli sm. Science. 2021 Feb 26;371(6532):eaay3446. doi: 10.1126/science.aay3446. Epub 2020 Dec 31. Science. 2021. PMID: 33384301 Free PMC article.
The bacterial replisome has factory-like localization.
Mangiameli SM, Cass JA, Merrikh H, Wiggins PA. Mangiameli SM, et al. Curr Genet. 2018 Oct;64(5):1029-1036. doi: 10.1007/s00294-018-0830-z. Epub 2018 Apr 9. Curr Genet. 2018. PMID: 29632994 Review.