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Page 1
Synthesis of [18F]PS13 and Evaluation as a PET Radioligand for Cyclooxygenase-1 in Monkey.
Taddei C, Morse CL, Kim MJ, Liow JS, Montero Santamaria J, Zhang A, Manly LS, Zanotti-Fregonara P, Gladding RL, Zoghbi SS, Innis RB, Pike VW. Taddei C, et al. Among authors: manly ls. ACS Chem Neurosci. 2021 Feb 3;12(3):517-530. doi: 10.1021/acschemneuro.0c00737. Epub 2021 Jan 25. ACS Chem Neurosci. 2021. PMID: 33491441 Free PMC article.
Synthesis and Screening in Mice of Fluorine-Containing PET Radioligands for TSPO: Discovery of a Promising 18F-Labeled Ligand.
Siméon FG, Lee JH, Morse CL, Stukes I, Zoghbi SS, Manly LS, Liow JS, Gladding RL, Dick RM, Yan X, Taliani S, Costa B, Martini C, Da Settimo F, Castellano S, Innis RB, Pike VW. Siméon FG, et al. Among authors: manly ls. J Med Chem. 2021 Nov 25;64(22):16731-16745. doi: 10.1021/acs.jmedchem.1c01562. Epub 2021 Nov 10. J Med Chem. 2021. PMID: 34756026 Free PMC article.
[11C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain.
Yan X, Telu S, Dick RM, Liow JS, Zanotti-Fregonara P, Morse CL, Manly LS, Gladding RL, Shrestha S, Lerchner W, Nagai Y, Minamimoto T, Zoghbi SS, Innis RB, Pike VW, Richmond BJ, Eldridge MA. Yan X, et al. Among authors: manly ls. J Cereb Blood Flow Metab. 2021 Oct;41(10):2571-2582. doi: 10.1177/0271678X211007949. Epub 2021 Apr 14. J Cereb Blood Flow Metab. 2021. PMID: 33853405 Free PMC article.
Discovery, Radiolabeling, and Evaluation of Subtype-Selective Inhibitors for Positron Emission Tomography Imaging of Brain Phosphodiesterase-4D.
Wakabayashi Y, Telu S, Dick RM, Fujita M, Ooms M, Morse CL, Liow JS, Hong JS, Gladding RL, Manly LS, Zoghbi SS, Mo X, D'Amato EC, Sindac JA, Nugent RA, Marron BE, Gurney ME, Innis RB, Pike VW. Wakabayashi Y, et al. Among authors: manly ls. ACS Chem Neurosci. 2020 May 6;11(9):1311-1323. doi: 10.1021/acschemneuro.0c00077. Epub 2020 Apr 8. ACS Chem Neurosci. 2020. PMID: 32212718 Free PMC article.
Late-onset Alzheimer disease risk variants mark brain regulatory loci.
Allen M, Kachadoorian M, Carrasquillo MM, Karhade A, Manly L, Burgess JD, Wang C, Serie D, Wang X, Siuda J, Zou F, Chai HS, Younkin C, Crook J, Medway C, Nguyen T, Ma L, Malphrus K, Lincoln S, Petersen RC, Graff-Radford NR, Asmann YW, Dickson DW, Younkin SG, Ertekin-Taner N. Allen M, et al. Among authors: manly l. Neurol Genet. 2015 Jul 23;1(2):e15. doi: 10.1212/NXG.0000000000000012. eCollection 2015 Aug. Neurol Genet. 2015. PMID: 27066552 Free PMC article.
Whole-body PET imaging in humans shows that 11C-PS13 is selective for cyclooxygenase-1 and can measure the in vivo potency of nonsteroidal anti-inflammatory drugs.
Kim MJ, Juarez Anaya F, Manly LS, Lee JH, Hong J, Shrestha S, Telu S, Henry K, Montero Santamaria JA, Liow JS, Zanotti-Fregonara P, Shetty HU, Zoghbi SS, Pike VW, Innis RB. Kim MJ, et al. Among authors: manly ls. J Nucl Med. 2022 Jul 7:jnumed.122.264061. doi: 10.2967/jnumed.122.264061. Online ahead of print. J Nucl Med. 2022. PMID: 35798558