Synthesis of some pyridine ribosides and their biological activity

A M Attia; H A Mansour; A A Almehdi; M M Abbasi

doi:10.1080/07328319908044882

Synthesis of some pyridine ribosides and their biological activity

Nucleosides Nucleotides. 1999 Oct;18(10):2301-6. doi: 10.1080/07328319908044882.

Authors

A M Attia¹, H A Mansour, A A Almehdi, M M Abbasi

Affiliation

¹ Department of Chemistry, Faculty of Education, Tanta University, Kafr El- Sheikh, Egypt.

PMID: 10616731
DOI: 10.1080/07328319908044882

Abstract

A synthesis of 1-(beta-D-ribofuranosyl)-pyridin-2-thiones via reaction of 3-cyanopyridin-2(1H)-thiones with 2,3,5-tri-O-benzoyl-D-ribofuranosyl bromide under basic conditions, followed by hydrolysis with methanolic ammonia is reported.

MeSH terms

Anti-HIV Agents / chemical synthesis*
Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacology
Chromatography, Thin Layer
Cytopathogenic Effect, Viral / drug effects
HIV-1 / drug effects
Humans
Magnetic Resonance Spectroscopy
Pyridines / chemistry*
Ribonucleosides / chemical synthesis*
Ribonucleosides / chemistry
Ribonucleosides / pharmacology
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
T-Lymphocytes / virology

Substances

Anti-HIV Agents
Pyridines
Ribonucleosides
pyridine