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4,967 results

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Page 1
MAP2 phosphorylation: mechanisms, functional consequences, and emerging insights.
Lyu J, DeMarco AG, Sweet RA, Grubisha MJ. Lyu J, et al. Front Cell Neurosci. 2025 Jul 30;19:1610371. doi: 10.3389/fncel.2025.1610371. eCollection 2025. Front Cell Neurosci. 2025. PMID: 40810115 Free PMC article. Review.
MAP2 undergoes extensive phosphorylation, which dynamically modulates these interactions and alters MAP2 functions. This review provides a comprehensive overview of MAP2 structure, its diverse functional roles in neurons, the kinases that regulate its phospho …
MAP2 undergoes extensive phosphorylation, which dynamically modulates these interactions and alters MAP2 functions. This revie …
MAP2 caps tau fibrils and inhibits aggregation.
Holden MR, Krzesinski BJ, Weismiller HA, Shady JR, Margittai M. Holden MR, et al. J Biol Chem. 2023 Jul;299(7):104891. doi: 10.1016/j.jbc.2023.104891. Epub 2023 Jun 5. J Biol Chem. 2023. PMID: 37286038 Free PMC article.
There is discrepancy about MAP2's involvement in pathology and its relationship with tau fibrillization. Here, we employed the entire repeat regions of 3R and 4R MAP2, to investigate their modulatory role in tau fibrillization. ...MAP2 monomers specifically b …
There is discrepancy about MAP2's involvement in pathology and its relationship with tau fibrillization. Here, we employed the entire …
MAP2 is differentially phosphorylated in schizophrenia, altering its function.
Grubisha MJ, Sun X, MacDonald ML, Garver M, Sun Z, Paris KA, Patel DS, DeGiosio RA, Lewis DA, Yates NA, Camacho C, Homanics GE, Ding Y, Sweet RA. Grubisha MJ, et al. Mol Psychiatry. 2021 Sep;26(9):5371-5388. doi: 10.1038/s41380-021-01034-z. Epub 2021 Feb 1. Mol Psychiatry. 2021. PMID: 33526823 Free PMC article.
Reduction of microtubule-associated protein 2 (MAP2) immunoreactivity (MAP2-IR) is present in individuals with Sz, despite no change in MAP2 protein levels. ...Because only a limited number of MAP2 interacting proteins have been previously identified, …
Reduction of microtubule-associated protein 2 (MAP2) immunoreactivity (MAP2-IR) is present in individuals with Sz, despite no …
MAP2: a sensitive cross-linker and adjustable spacer in dendritic architecture.
Friedrich P, Aszódi A. Friedrich P, et al. FEBS Lett. 1991 Dec 16;295(1-3):5-9. doi: 10.1016/0014-5793(91)81371-e. FEBS Lett. 1991. PMID: 1765166 Free article. Review.
Microtubule-associated protein 2 (MAP2), a long, filamentous molecule thought to cross-link dendritic cytoskeleton, is rich in PEST sequences, putative signals for rapid proteolytic degradation. ...Such a structural transition may provide a mechanism for the putative role …
Microtubule-associated protein 2 (MAP2), a long, filamentous molecule thought to cross-link dendritic cytoskeleton, is rich in PEST s …
Differential regulation of MAP2 by phosphorylation events in proline-rich versus C-terminal domains.
DeGiosio RA, Needham PG, Andrews OA, Tristan H, Grubisha MJ, Brodsky JL, Camacho C, Sweet RA. DeGiosio RA, et al. FASEB J. 2023 Oct;37(10):e23194. doi: 10.1096/fj.202300486R. FASEB J. 2023. PMID: 37702880 Free PMC article.
MAP2 is a critical cytoskeletal regulator in neurons. The phosphorylation of MAP2 (MAP2-P) is well known to regulate core functions of MAP2, including microtubule (MT)/actin binding and facilitation of tubulin polymerization. ...The phosphopeptides ori …
MAP2 is a critical cytoskeletal regulator in neurons. The phosphorylation of MAP2 (MAP2-P) is well known to regulate co …
MAP2 Splicing is Altered in Huntington's Disease.
Cabrera JR, Lucas JJ. Cabrera JR, et al. Brain Pathol. 2017 Mar;27(2):181-189. doi: 10.1111/bpa.12387. Epub 2016 Jul 7. Brain Pathol. 2017. PMID: 27098187 Free PMC article.
The main microtubule-associated protein in dendrites is MAP2. The low-molecular weight isoforms of MAP2 (LMW-MAP2) are the juvenile forms resulting from exclusion of the sequence encoded by exons E7-E9 and are downregulated after the early stages of neuronal …
The main microtubule-associated protein in dendrites is MAP2. The low-molecular weight isoforms of MAP2 (LMW-MAP2) are …
Deciphering the alteration of MAP2 interactome caused by a schizophrenia-associated phosphorylation.
Lyu J, MacDonald ML, Ruiz S, Chou S, Gilardi J, Buchwald SC, Grubisha MJ, Sweet RA. Lyu J, et al. Neurobiol Dis. 2024 Dec;203:106731. doi: 10.1016/j.nbd.2024.106731. Epub 2024 Nov 10. Neurobiol Dis. 2024. PMID: 39532265 Free PMC article.
We sought to determine how this hyperphosphorylation affects the MAP2 interactome to provide insights into the disorder's mechanisms. We investigated the MAP2 interactome using co-immunoprecipitation and mass spectrometry in MAP2(S1782E) and MAP2(WT) m …
We sought to determine how this hyperphosphorylation affects the MAP2 interactome to provide insights into the disorder's mechanisms. …
Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function.
Sánchez C, Díaz-Nido J, Avila J. Sánchez C, et al. Prog Neurobiol. 2000 Jun;61(2):133-68. doi: 10.1016/s0301-0082(99)00046-5. Prog Neurobiol. 2000. PMID: 10704996 Review.
MAP2 phosphorylation seems to control its association with the cytoskeleton and it is developmentally regulated. ...These putative functions of MAP2 have also been proposed to play important roles in the outgrowth of neuronal processes, synaptic plasticity and neuro …
MAP2 phosphorylation seems to control its association with the cytoskeleton and it is developmentally regulated. ...These putative fu …
A three-dimensional human neural cell culture model of Alzheimer's disease.
Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. Choi SH, et al. Nature. 2014 Nov 13;515(7526):274-8. doi: 10.1038/nature13800. Epub 2014 Oct 12. Nature. 2014. PMID: 25307057 Free PMC article.
More than a marker: potential pathogenic functions of MAP2.
DeGiosio RA, Grubisha MJ, MacDonald ML, McKinney BC, Camacho CJ, Sweet RA. DeGiosio RA, et al. Front Mol Neurosci. 2022 Sep 16;15:974890. doi: 10.3389/fnmol.2022.974890. eCollection 2022. Front Mol Neurosci. 2022. PMID: 36187353 Free PMC article.
Here we review the understood structure and functions of MAP2, including in neurite outgrowth, synaptic plasticity, and regulation of protein folding/transport. ...We propose pathways by which MAP2 pathology could contribute to endophenotypes which characterize thes …
Here we review the understood structure and functions of MAP2, including in neurite outgrowth, synaptic plasticity, and regulation of …
4,967 results