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136 results

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Page 1
Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management.
Jain P, Wang M. Jain P, et al. Am J Hematol. 2019 Jun;94(6):710-725. doi: 10.1002/ajh.25487. Epub 2019 Apr 19. Am J Hematol. 2019. PMID: 30963600 Free article. Review.
Studies focusing on mutational dynamics and clonal evolution on Bruton's tyrosine kinase (BTK) inhibitors (ibrutinib, acalabrutinib) and/or Bcl2 antagonists (venetoclax) have further clarified the prognostic impact of somatic mutations in TP53, BIRC3, CDKN2A, MAP3K14, NOTC …
Studies focusing on mutational dynamics and clonal evolution on Bruton's tyrosine kinase (BTK) inhibitors (ibrutinib, acalabrutinib) and/or …
NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition.
Vesting AJ, Jais A, Klemm P, Steuernagel L, Wienand P, Fog-Tonnesen M, Hvid H, Schumacher AL, Kukat C, Nolte H, Georgomanolis T, Altmüller J, Pasparakis M, Schmidt A, Krüger M, Supprian MS, Waisman A, Straub BK, Raschzok N, Bernier M, Birkenfeld AL, Hövelmeyer N, Brüning JC, Wunderlich FT. Vesting AJ, et al. Mol Metab. 2022 Dec;66:101626. doi: 10.1016/j.molmet.2022.101626. Epub 2022 Nov 7. Mol Metab. 2022. PMID: 36356831 Free PMC article.
METHODS: Here, we investigated non-canonical NFkappaB-inducing kinase (NIK/MAP3K14) in metabolic NASH, NASH to HCC transition, and DEN-induced HCC. To this end, we performed dietary and chemical interventions in mice that were analyzed via single nucleus sequencing, gene e …
METHODS: Here, we investigated non-canonical NFkappaB-inducing kinase (NIK/MAP3K14) in metabolic NASH, NASH to HCC transition, and DE …
A diverse range of gene products are effectors of the type I interferon antiviral response.
Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM. Schoggins JW, et al. Nature. 2011 Apr 28;472(7344):481-5. doi: 10.1038/nature09907. Epub 2011 Apr 10. Nature. 2011. PMID: 21478870 Free PMC article.
Broadly acting effectors included IRF1, C6orf150 (also known as MB21D1), HPSE, RIG-I (also known as DDX58), MDA5 (also known as IFIH1) and IFITM3, whereas more targeted antiviral specificity was observed with DDX60, IFI44L, IFI6, IFITM2, MAP3K14, MOV10, NAMPT (also known a …
Broadly acting effectors included IRF1, C6orf150 (also known as MB21D1), HPSE, RIG-I (also known as DDX58), MDA5 (also known as IFIH1) and I …
Potential Role of MAP3K14 in Hepatocellular Carcinoma: A Study Based on Comprehensive Bioinformatical Analysis and Validation.
Tang K, Lin W, Wang D, Hu X, Chen Z, Chen J, Liang B, Zhang L, Qin P, Wu D. Tang K, et al. J Cancer. 2024 Mar 17;15(9):2731-2745. doi: 10.7150/jca.95322. eCollection 2024. J Cancer. 2024. PMID: 38577603 Free PMC article.

The expression of MAP3K14 protein in HCC was detected by immunohistochemical method. The mRNA and protein expression levels of MAP3K14 in tumor tissues were higher than those in normal tissues (p < 0.05). ...MAP3K14 may serve as a potential biomarker for p

…
The expression of MAP3K14 protein in HCC was detected by immunohistochemical method. The mRNA and protein expression levels of MAP …
Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection.
Hamdan TA, Bhat H, Cham LB, Adomati T, Lang J, Li F, Murtaza A, Hardt C, Lang PA, Duhan V, Lang KS. Hamdan TA, et al. Pathogens. 2020 Feb 4;9(2):96. doi: 10.3390/pathogens9020096. Pathogens. 2020. PMID: 32033109 Free PMC article.
When alymphoplasia mice (aly/aly, Map3k14(aly/aly), or Nik(aly/aly)), which carry a mutation in Map3k14, were infected with LCMV or vesicular stomatitis virus (VSV), they display early reductions in early viral replication in the spleen, reduced innate and adaptive …
When alymphoplasia mice (aly/aly, Map3k14(aly/aly), or Nik(aly/aly)), which carry a mutation in Map3k14, were infected with LC …
Genetic mutations and features of mantle cell lymphoma: a systematic review and meta-analysis.
Hill HA, Qi X, Jain P, Nomie K, Wang Y, Zhou S, Wang ML. Hill HA, et al. Blood Adv. 2020 Jul 14;4(13):2927-2938. doi: 10.1182/bloodadvances.2019001350. Blood Adv. 2020. PMID: 32598477 Free PMC article.
The genes with the highest mutational frequency difference (>5%) are TP53, ATM, KMT2A, MAP3K14, BTK, TRAF2, CHD2, TLR2, ARID2, RIMS2, NOTCH2, TET2, SPEN, NSD2, CARD11, CCND1, SP140, CDKN2A, and S1PR1. ...
The genes with the highest mutational frequency difference (>5%) are TP53, ATM, KMT2A, MAP3K14, BTK, TRAF2, CHD2, TLR2, ARID2, RIM …
EGR1 knockdown confers protection against ferroptosis and ameliorates intervertebral disc cartilage degeneration by inactivating the MAP3K14/NF-kappaB axis.
Zhang J, He L, Li Q, Gao J, Zhang E, Feng H. Zhang J, et al. Genomics. 2023 Sep;115(5):110683. doi: 10.1016/j.ygeno.2023.110683. Epub 2023 Jul 13. Genomics. 2023. PMID: 37453477 Free article.
EGR1 and MAP3K14 were overexpressed in clinical samples and cell models of IVDD. In IVDD cell models, EGR1 knockdown reduced ferroptosis and cartilage degeneration, which was reversed by MAP3K14 overexpression or Erastin treatment. NF-kappaB pathway inhibition nulli …
EGR1 and MAP3K14 were overexpressed in clinical samples and cell models of IVDD. In IVDD cell models, EGR1 knockdown reduced ferropto …
Potentially functional variants of MAP3K14 in the NF-kappaB signaling pathway genes predict survival of HBV-related hepatocellular carcinoma patients.
Huang Q, Liu Y, Qiu M, Lin Q, Wei X, Zhou Z, Liang X, Li R, Chen W, Zhou X, Yu H. Huang Q, et al. Front Oncol. 2022 Sep 2;12:990160. doi: 10.3389/fonc.2022.990160. eCollection 2022. Front Oncol. 2022. PMID: 36119471 Free PMC article.
Further eQTL analysis demonstrated that significant correlations between the rs2074292 (G>A) A allele was associated with higher mRNA expression levels of MAP3K14 (P=0.044) in normal liver tissue, which was associated with worse survival of HBV-HCC patients. ...The addi …
Further eQTL analysis demonstrated that significant correlations between the rs2074292 (G>A) A allele was associated with higher mRNA exp …
Evaluation of a plasma cell-free DNA methylation test for colorectal cancer diagnosis: a multicenter clinical study.
Wang Z, He Z, Lin R, Feng Z, Li X, Sui X, Gu L, Xia T, Zhou D, Zhao B, Li Y, Li Z, Bai Y. Wang Z, et al. BMC Med. 2024 Oct 8;22(1):436. doi: 10.1186/s12916-024-03662-y. BMC Med. 2024. PMID: 39379942 Free PMC article. Clinical Trial.
The MethyDT test (IColohunter), which detects methylation levels of NTMT1 and MAP3K14-AS1, exhibited potential in discriminating CRC, but its clinical performance needs to be validated in large-scale populations. ...Plasma samples were collected to detect methylation level …
The MethyDT test (IColohunter), which detects methylation levels of NTMT1 and MAP3K14-AS1, exhibited potential in discriminating CRC, …
136 results