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CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells.
Tyagi A, Kaushal K, Chandrasekaran AP, Sarodaya N, Das S, Park CH, Hong SH, Kim KS, Ramakrishna S. Tyagi A, et al. Theranostics. 2022 Aug 8;12(13):5949-5970. doi: 10.7150/thno.72826. eCollection 2022. Theranostics. 2022. PMID: 35966591 Free PMC article.
We analyzed K48- and K63-linked polyubiquitination of MAST1 protein and mapped the interacting domain between USP1 and MAST1 by immunoprecipitation assay. ...Loss of USP1 led to attenuation of MAST1-mediated cisplatin-resistance both in vitro and in vivo. The …
We analyzed K48- and K63-linked polyubiquitination of MAST1 protein and mapped the interacting domain between USP1 and MAST1 b …
USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells.
Karapurkar JK, Colaco JC, Suresh B, Tyagi A, Woo SH, Jo WJ, Ko N, Singh V, Hong SH, Oh SJ, Kim KS, Ramakrishna S. Karapurkar JK, et al. Cell Mol Life Sci. 2024 Mar 18;81(1):145. doi: 10.1007/s00018-024-05187-2. Cell Mol Life Sci. 2024. PMID: 38498222 Free PMC article.
The expression level and protein turnover of MAST1 is a major factor driving cisplatin resistance in many cancer types. Here we report that the USP28 interacts and extends the half-life of MAST1 protein by its deubiquitinating activity. The expression pattern of USP …
The expression level and protein turnover of MAST1 is a major factor driving cisplatin resistance in many cancer types. Here we repor …
Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.
Tripathy R, Leca I, van Dijk T, Weiss J, van Bon BW, Sergaki MC, Gstrein T, Breuss M, Tian G, Bahi-Buisson N, Paciorkowski AR, Pagnamenta AT, Wenninger-Weinzierl A, Martinez-Reza MF, Landler L, Lise S, Taylor JC, Terrone G, Vitiello G, Del Giudice E, Brunetti-Pierri N, D'Amico A, Reymond A, Voisin N, Bernstein JA, Farrelly E, Kini U, Leonard TA, Valence S, Burglen L, Armstrong L, Hiatt SM, Cooper GM, Aldinger KA, Dobyns WB, Mirzaa G, Pierson TM, Baas F, Chelly J, Cowan NJ, Keays DA. Tripathy R, et al. Neuron. 2018 Dec 19;100(6):1354-1368.e5. doi: 10.1016/j.neuron.2018.10.044. Epub 2018 Nov 15. Neuron. 2018. PMID: 30449657 Free PMC article.
We show that MAST1 is a microtubule-associated protein that is predominantly expressed in post-mitotic neurons and is present in both dendritic and axonal compartments. We further show that Mast1 null animals are phenotypically normal, whereas the deletion of a sing …
We show that MAST1 is a microtubule-associated protein that is predominantly expressed in post-mitotic neurons and is present in both …
MAST1-related mega-corpus-callosum syndrome with central hypogonadism.
Sloboda N, Renard E, Lambert L, Bonnet C, Leheup B, Todosi C, Schmitt E, Feillet F, Feigerlova E, Piton A, Journeau P, Klein M, Maillard L, Chelly J, Renaud M. Sloboda N, et al. Eur J Med Genet. 2023 Nov;66(11):104853. doi: 10.1016/j.ejmg.2023.104853. Epub 2023 Sep 25. Eur J Med Genet. 2023. PMID: 37758169
To date, patients with MAST1 gene mutations were mostly young children with central nervous system involvement, impaired motor function, speech delay, and brain magnetic resonance imaging (MRI) abnormalities. ...CONCLUSION: This is the first patient with MAST1 gene …
To date, patients with MAST1 gene mutations were mostly young children with central nervous system involvement, impaired motor functi …
Mast1 mediates radiation-induced gastric injury via the P38 MAPK pathway.
Ding W, Lu Y, Zhou A, Chen Y, Wang Z, Wang L, Tian Y. Ding W, et al. Exp Cell Res. 2021 Dec 15;409(2):112913. doi: 10.1016/j.yexcr.2021.112913. Epub 2021 Nov 11. Exp Cell Res. 2021. PMID: 34774870 Free article.
Furthermore, functional assays showed that knockdown of Mast1 inhibited growth and promoted apoptosis in gastric epithelial cells, while overexpression of Mast1 protected gastric epithelial cells from radiation damage. ...The apoptosis caused by knockdown of Mast …
Furthermore, functional assays showed that knockdown of Mast1 inhibited growth and promoted apoptosis in gastric epithelial cells, wh …
MAST1 modulates neuronal differentiation and cell cycle exit via P27 in neuroblastoma cells.
Jing T, Ma J, Zhao H, Zhang J, Jiang N, Ma D. Jing T, et al. FEBS Open Bio. 2020 Jun;10(6):1104-1114. doi: 10.1002/2211-5463.12860. Epub 2020 Apr 29. FEBS Open Bio. 2020. PMID: 32291963 Free PMC article.
Here, we investigated how MAST1 contributes to neuronal development. We report that MAST1 is upregulated during neuronal differentiation of the human neuroblastoma cell line, SH-SY5Y. ...Cell cycle analyses revealed that MAST1-depleted cells did not undergo c …
Here, we investigated how MAST1 contributes to neuronal development. We report that MAST1 is upregulated during neuronal diffe …
MAST1 variant causes mega-corpus-callosum syndrome with cortical malformations but without cerebellar hypoplasia.
Rodríguez-García ME, Cotrina-Vinagre FJ, Gómez-Cano MLÁ, Martínez de Aragón A, Martín-Hernández E, Martínez-Azorín F. Rodríguez-García ME, et al. Am J Med Genet A. 2020 Jun;182(6):1483-1490. doi: 10.1002/ajmg.a.61560. Epub 2020 Mar 21. Am J Med Genet A. 2020. PMID: 32198973
Whole-exome sequence uncovered a de novo variant in the microtubule associated serine/threonine kinase 1 gene (MAST1; NM_014975.3:c.1565G>A:p.(Gly522Glu)) that encodes for the MAST1. Only 12 patients have been identified worldwide with 10 different variants in th …
Whole-exome sequence uncovered a de novo variant in the microtubule associated serine/threonine kinase 1 gene (MAST1; NM_014975.3:c.1 …
MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation.
Jin L, Chun J, Pan C, Li D, Lin R, Alesi GN, Wang X, Kang HB, Song L, Wang D, Zhang G, Fan J, Boggon TJ, Zhou L, Kowalski J, Qu CK, Steuer CE, Chen GZ, Saba NF, Boise LH, Owonikoko TK, Khuri FR, Magliocca KR, Shin DM, Lonial S, Kang S. Jin L, et al. Cancer Cell. 2018 Aug 13;34(2):315-330.e7. doi: 10.1016/j.ccell.2018.06.012. Epub 2018 Jul 19. Cancer Cell. 2018. PMID: 30033091 Free PMC article.
We show clinical evidence that expression of MAST1, both initial and cisplatin-induced, contributes to platinum resistance and worse clinical outcome. Targeting MAST1 with lestaurtinib, a recently identified MAST1 inhibitor, restores cisplatin sensitivity, le …
We show clinical evidence that expression of MAST1, both initial and cisplatin-induced, contributes to platinum resistance and worse …
Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation.
Pan C, Chun J, Li D, Boese AC, Li J, Kang J, Umano A, Jiang Y, Song L, Magliocca KR, Chen ZG, Saba NF, Shin DM, Owonikoko TK, Lonial S, Jin L, Kang S. Pan C, et al. J Clin Invest. 2019 Oct 1;129(10):4110-4123. doi: 10.1172/JCI125963. J Clin Invest. 2019. PMID: 31449053 Free PMC article.
Microtubule-associated serine/threonine kinase 1 (MAST1) is a central driver of cisplatin resistance in human cancers. However, the molecular mechanism regulating MAST1 levels in cisplatin-resistant tumors is unknown. ...Mechanistically, interaction of hsp90B with …
Microtubule-associated serine/threonine kinase 1 (MAST1) is a central driver of cisplatin resistance in human cancers. However, the m …
Pulling a MAST1 on Cisplatin Resistance.
Jaykumar AB, Karra AS, Cobb MH. Jaykumar AB, et al. Cancer Cell. 2018 Aug 13;34(2):183-185. doi: 10.1016/j.ccell.2018.07.010. Cancer Cell. 2018. PMID: 30107173 Free article.
In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-ind …
In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They …
55 results