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Page 1
Mast4 determines the cell fate of MSCs for bone and cartilage development.
Kim P, Park J, Lee DJ, Mizuno S, Shinohara M, Hong CP, Jeong Y, Yun R, Park H, Park S, Yang KM, Lee MJ, Jang SP, Kim HY, Lee SJ, Song SU, Park KS, Tanaka M, Ohshima H, Cho JW, Sugiyama F, Takahashi S, Jung HS, Kim SJ. Kim P, et al. Nat Commun. 2022 Jul 8;13(1):3960. doi: 10.1038/s41467-022-31697-3. Nat Commun. 2022. PMID: 35803931 Free PMC article.
Suppression of Mast4 by TGF-beta1 led to increased Sox9 stability by blocking Mast4-induced Sox9 serine 494 phosphorylation and subsequent proteasomal degradation, ultimately enhancing chondrogenesis of MSCs. ...Interestingly, Mast4 depletion in MSCs facilita …
Suppression of Mast4 by TGF-beta1 led to increased Sox9 stability by blocking Mast4-induced Sox9 serine 494 phosphorylation an …
MAST4 controls cell cycle in spermatogonial stem cells.
Lee SJ, Kim KH, Lee DJ, Kim P, Park J, Kim SJ, Jung HS. Lee SJ, et al. Cell Prolif. 2023 Apr;56(4):e13390. doi: 10.1111/cpr.13390. Epub 2023 Jan 2. Cell Prolif. 2023. PMID: 36592615 Free PMC article.
Finally, the testis tissues were cultured in vitro to examine the regulation of cell cycle by MAST4 pathway. Mast4 KO mice showed infertility with Sertoli cell-only syndrome and reduced sperm count. ...MAST4 is essential for maintaining cell cycle in SSCs via …
Finally, the testis tissues were cultured in vitro to examine the regulation of cell cycle by MAST4 pathway. Mast4 KO mice sho …
Estrogen-Responsive Gene MAST4 Regulates Myeloma Bone Disease.
Cui Y, Wang F, Zhang D, Huang J, Yang Y, Xu J, Gao Y, Ding H, Qu Y, Zhang W, Liu W, Pan L, Zhang L, Liu Z, Niu T, Liu T, Zheng Y. Cui Y, et al. J Bone Miner Res. 2022 Apr;37(4):711-723. doi: 10.1002/jbmr.4507. Epub 2022 Feb 11. J Bone Miner Res. 2022. PMID: 35064934 Free article.
Based on this clinical observation, we found that estrogen cell signaling played a regulatory role in MM bone disease (MMBD), and the estrogen-responsive gene microtubule-associated serine/threonine kinase family member 4 (MAST4) was a critical factor. The presence of estr …
Based on this clinical observation, we found that estrogen cell signaling played a regulatory role in MM bone disease (MMBD), and the estrog …
MAST4 promotes primary ciliary resorption through phosphorylation of Tctex-1.
Sakaji K, Ebrahimiazar S, Harigae Y, Ishibashi K, Sato T, Yoshikawa T, Atsumi GI, Sung CH, Saito M. Sakaji K, et al. Life Sci Alliance. 2023 Sep 19;6(11):e202301947. doi: 10.26508/lsa.202301947. Print 2023 Nov. Life Sci Alliance. 2023. PMID: 37726137 Free PMC article.
Here, we show that microtubule-associated serine/threonine kinase family member 4 (MAST4) is localized at the primary cilium. Suppressing MAST4 blocks serum-induced ciliary resorption, and overexpressing MAST4 accelerates ciliary resorption. Tctex-1 binds to …
Here, we show that microtubule-associated serine/threonine kinase family member 4 (MAST4) is localized at the primary cilium. Suppres …
MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis.
Lee DJ, Kim P, Kim HY, Park J, Lee SJ, An H, Heo JS, Lee MJ, Ohshima H, Mizuno S, Takahashi S, Jung HS, Kim SJ. Lee DJ, et al. Exp Mol Med. 2024 Jul;56(7):1606-1619. doi: 10.1038/s12276-024-01264-5. Epub 2024 Jul 1. Exp Mol Med. 2024. PMID: 38945953 Free PMC article.
In addition, Mast4 KO incisors showed abnormal enamel maturation, and stem cell maintenance was inhibited as amelogenesis was accelerated with Wnt signal downregulation. ...Taken together, our data reveal a novel role for MAST4 as a critical regulator of the entire …
In addition, Mast4 KO incisors showed abnormal enamel maturation, and stem cell maintenance was inhibited as amelogenesis was acceler …
Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway.
Lee SJ, Park J, Lee DJ, Otsu K, Kim P, Mizuno S, Lee MJ, Kim HY, Harada H, Takahashi S, Kim SJ, Jung HS. Lee SJ, et al. Cell Death Differ. 2021 May;28(5):1441-1454. doi: 10.1038/s41418-020-00670-2. Epub 2020 Nov 20. Cell Death Differ. 2021. PMID: 33219327 Free PMC article.
This study investigated the role of microtubule-associated serine/threonine kinase family member 4 (MAST4) in spermatogenesis in mice. MAST4 was localized in Sertoli cells before puberty, providing a somatic niche for spermatogenesis in mice and MAST4 express …
This study investigated the role of microtubule-associated serine/threonine kinase family member 4 (MAST4) in spermatogenesis in mice …
De novo variants in MAST4 related to neurodevelopmental disorders with developmental delay and infantile spasms: Genotype-phenotype association.
Zhang X, Xiao N, Cao Y, Peng Y, Lian A, Chen Y, Wang P, Gu W, Xiao B, Yu J, Wang H, Shu L. Zhang X, et al. Front Mol Neurosci. 2023 Feb 22;16:1097553. doi: 10.3389/fnmol.2023.1097553. eCollection 2023. Front Mol Neurosci. 2023. PMID: 36910266 Free PMC article.
CONCLUSION: Our results revealed that the variants of MAST4 gene might lead to neurodevelopmental disorders with developmental delay and infantile spasm. Thus, MAST4 variants should be considered the potential candidate gene in patients with neurodevelopmental disor …
CONCLUSION: Our results revealed that the variants of MAST4 gene might lead to neurodevelopmental disorders with developmental delay …
Nuclear MAST4 Suppresses FOXO3 through Interaction with AKT3 and Induces Chemoresistance in Pancreatic Ductal Carcinoma.
Fujiwara-Tani R, Sasaki T, Bhawal UK, Mori S, Ogata R, Sasaki R, Ikemoto A, Kishi S, Fujii K, Ohmori H, Sho M, Kuniyasu H. Fujiwara-Tani R, et al. Int J Mol Sci. 2024 Apr 5;25(7):4056. doi: 10.3390/ijms25074056. Int J Mol Sci. 2024. PMID: 38612866 Free PMC article.
MAST4 knockdown effectively suppressed AKT3 overexpression, and both MAST4 and AKT3 translocation into the nucleus, phosphorylating forkhead box O3a (FOXO3) in MIA-GEM cells. ...Elevated MAST4 expression correlated with a poorer prognosis in PDAC. Consequentl …
MAST4 knockdown effectively suppressed AKT3 overexpression, and both MAST4 and AKT3 translocation into the nucleus, phosphoryl …
Exploring the Sheep MAST4 Gene Variants and Their Associations with Litter Size.
Akhmet N, Zhu L, Song J, Akhatayeva Z, Zhang Q, Su P, Li R, Pan C, Lan X. Akhmet N, et al. Animals (Basel). 2024 Feb 11;14(4):591. doi: 10.3390/ani14040591. Animals (Basel). 2024. PMID: 38396560 Free PMC article.
Moreover, polymerase chain reaction (PCR) genotyping of the MAST4 gene polymorphisms in (n = 566) Australian white sheep (AUW) was performed. The 3 identified polymorphisms were not homogeneously distributed across the 26 examined sheep breeds. ...These results suggest tha …
Moreover, polymerase chain reaction (PCR) genotyping of the MAST4 gene polymorphisms in (n = 566) Australian white sheep (AUW) was pe …
Blood DNA methylation signature of diet quality and association with cardiometabolic traits.
Domínguez-Barragán J, Fernández-Sanlés A, Hernáez Á, Llauradó-Pont J, Marrugat J, Robinson O, Tzoulaki I, Elosua R, Lassale C. Domínguez-Barragán J, et al. Eur J Prev Cardiol. 2024 Jan 25;31(2):191-202. doi: 10.1093/eurjpc/zwad317. Eur J Prev Cardiol. 2024. PMID: 37793095 Free PMC article.
Mendelian randomization analyses suggested that genetically determined methylation levels corresponding to lower diet quality at cg02079413 (SNORA54), cg02107842 (MAST4), and cg23761815 (SLC29A3) were causally associated with higher BMI and at cg05399785 (WDR8) with greate …
Mendelian randomization analyses suggested that genetically determined methylation levels corresponding to lower diet quality at cg02079413 …
52 results