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Elarekibep (PRS-060/AZD1402), a new class of inhaled Anticalin medicine targeting IL-4Ra for type 2 endotype asthma.
Matschiner G, Fitzgerald MF, Moebius U, Hohlbaum AM, Gille H, Jensen K, Kirchfeld K, Rattenstetter B, Laforge A, Bel Aiba RS, Ciccotosto J, Nyugen H, Foster ML, Snouwaert JN, Nguyen M, Koller BH, Matis L, Anderson GP, Olwill SA. Matschiner G, et al. J Allergy Clin Immunol. 2023 Apr;151(4):966-975. doi: 10.1016/j.jaci.2022.12.815. Epub 2022 Dec 30. J Allergy Clin Immunol. 2023. PMID: 36592703 Free article.
Bivalent inhibition of human beta-tryptase.
Schaschke N, Matschiner G, Zettl F, Marquardt U, Bergner A, Bode W, Sommerhoff CP, Moroder L. Schaschke N, et al. Among authors: matschiner g. Chem Biol. 2001 Apr;8(4):313-27. doi: 10.1016/s1074-5521(01)00011-4. Chem Biol. 2001. PMID: 11325588
Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs.
Danov O, Jiménez Delgado SM, Obernolte H, Seehase S, Dehmel S, Braubach P, Fieguth HG, Matschiner G, Fitzgerald M, Jonigk D, Knauf S, Pfennig O, Warnecke G, Wichmann J, Braun A, Sewald K. Danov O, et al. Among authors: matschiner g. PLoS One. 2018 Nov 30;13(11):e0207767. doi: 10.1371/journal.pone.0207767. eCollection 2018. PLoS One. 2018. PMID: 30500834 Free PMC article.
Pulmonary-delivered Anticalin Jagged-1 antagonists reduce experimental airway mucus hyperproduction and obstruction.
Heinzelmann K, Fysikopoulos A, Jaquin TJ, Peper-Gabriel JK, Hansbauer EM, Grüner S, Prassler J, Wurzenberger C, Kennedy JGC, Snead JY, Wrennall JA, Heinig K, Wurzenberger C, Bel Aiba RS, Tarran R, Livraghi-Butrico A, Fitzgerald MF, Anderson GP, Rothe C, Matschiner G, Olwill SA, Hagner M. Heinzelmann K, et al. Among authors: matschiner g. Am J Physiol Lung Cell Mol Physiol. 2024 Nov 5. doi: 10.1152/ajplung.00059.2024. Online ahead of print. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 39499257
Tumor-Localized Costimulatory T-Cell Engagement by the 4-1BB/HER2 Bispecific Antibody-Anticalin Fusion PRS-343.
Hinner MJ, Aiba RSB, Jaquin TJ, Berger S, Dürr MC, Schlosser C, Allersdorfer A, Wiedenmann A, Matschiner G, Schüler J, Moebius U, Rothe C, Matis L, Olwill SA. Hinner MJ, et al. Among authors: matschiner g. Clin Cancer Res. 2019 Oct 1;25(19):5878-5889. doi: 10.1158/1078-0432.CCR-18-3654. Epub 2019 May 28. Clin Cancer Res. 2019. PMID: 31138587
18 results