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Page 1
Glutamine sensing licenses cholesterol synthesis.
Garcia BM, Melchinger P, Medeiros T, Hendrix S, Prabhu K, Corrado M, Kingma J, Gorbatenko A, Deshwal S, Veronese M, Scorrano L, Pearce E, Giavalisco P, Zelcer N, Pernas L. Garcia BM, et al. EMBO J. 2024 Dec;43(23):5837-5856. doi: 10.1038/s44318-024-00269-0. Epub 2024 Oct 21. EMBO J. 2024. PMID: 39433901 Free article.
Multiparametric magnetic resonance imaging to characterize cabotegravir long-acting formulation depot kinetics in healthy adult volunteers.
Jucker BM, Fuchs EJ, Lee S, Damian V, Galette P, Janiczek R, Macura KJ, Jacobs MA, Weld ED, Solaiyappan M, D'Amico R, Shaik JS, Bakshi K, Han K, Ford S, Margolis D, Spreen W, Gupta MK, Hendrix CW, Patel P. Jucker BM, et al. Br J Clin Pharmacol. 2022 Feb;88(4):1655-1666. doi: 10.1111/bcp.14977. Epub 2021 Jul 31. Br J Clin Pharmacol. 2022. PMID: 34240449 Free PMC article. Clinical Trial.
Linear regression analysis examined correlations between MRI-derived parameters and plasma cabotegravir exposure metrics, including maximum observed concentration (C(max) ) and partial area under the concentration-time curve (AUC) through Weeks 4 and 8. ...Although injecti …
Linear regression analysis examined correlations between MRI-derived parameters and plasma cabotegravir exposure metrics, including maximum …
Close Cassini flybys of Saturn's ring moons Pan, Daphnis, Atlas, Pandora, and Epimetheus.
Buratti BJ, Thomas PC, Roussos E, Howett C, Seiß M, Hendrix AR, Helfenstein P, Brown RH, Clark RN, Denk T, Filacchione G, Hoffmann H, Jones GH, Khawaja N, Kollmann P, Krupp N, Lunine J, Momary TW, Paranicas C, Postberg F, Sachse M, Spahn F, Spencer J, Srama R, Albin T, Baines KH, Ciarniello M, Economou T, Hsu HW, Kempf S, Krimigis SM, Mitchell D, Moragas-Klostermeyer G, Nicholson PD, Porco CC, Rosenberg H, Simolka J, Soderblom LA. Buratti BJ, et al. Science. 2019 Jun 14;364(6445):eaat2349. doi: 10.1126/science.aat2349. Epub 2019 Mar 28. Science. 2019. PMID: 30923171
Cytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maraviroc.
Lu Y, Hendrix CW, Bumpus NN. Lu Y, et al. Drug Metab Dispos. 2012 Dec;40(12):2221-30. doi: 10.1124/dmd.112.048298. Epub 2012 Aug 24. Drug Metab Dispos. 2012. PMID: 22923690 Free PMC article.
For the formation of this metabolite, the V(max) values for CYP3A4 and CYP3A5 were 0.04 and 0.93 pmol . min-1 . pmol P450-1, and the K(m) values were 11.1 and 48.9 muM, respectively. ...
For the formation of this metabolite, the V(max) values for CYP3A4 and CYP3A5 were 0.04 and 0.93 pmol . min-1 . pmol P450-1, and the …
Noise levels in a burn intensive care unit.
Cordova AC, Logishetty K, Fauerbach J, Price LA, Gibson BR, Milner SM. Cordova AC, et al. Burns. 2013 Feb;39(1):44-8. doi: 10.1016/j.burns.2012.02.033. Epub 2012 Apr 27. Burns. 2013. PMID: 22541620
There was no significant difference in dB(A)(max) or dB(A)(min) between shift changes, day or night-time (p>0.05). However, night-time minimum values were consistently lower. ...
There was no significant difference in dB(A)(max) or dB(A)(min) between shift changes, day or night-time (p>0.05). However, night- …
A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel.
Keller MJ, Madan RP, Torres NM, Fazzari MJ, Cho S, Kalyoussef S, Shust G, Mesquita PM, Louissaint N, Chen J, Cohen HW, Diament EC, Lee AC, Soto-Torres L, Hendrix CW, Herold BC. Keller MJ, et al. PLoS One. 2011 Jan 25;6(1):e16475. doi: 10.1371/journal.pone.0016475. PLoS One. 2011. PMID: 21283552 Free PMC article. Clinical Trial.
The activity correlated significantly with CVL concentration of tenofovir (r = 0.6, p<0.001) and fit a sigmoid E(max) pharmacodynamic model. Anti-HIV activity in CVL from women who applied tenofovir persisted when virus was introduced in semen, whereas endogenous anti-H …
The activity correlated significantly with CVL concentration of tenofovir (r = 0.6, p<0.001) and fit a sigmoid E(max) pharmacodyna …
Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects.
Stone ND, Dunaway SB, Flexner C, Tierney C, Calandra GB, Becker S, Cao YJ, Wiggins IP, Conley J, MacFarland RT, Park JG, Lalama C, Snyder S, Kallungal B, Klingman KL, Hendrix CW. Stone ND, et al. Antimicrob Agents Chemother. 2007 Jul;51(7):2351-8. doi: 10.1128/AAC.00013-07. Epub 2007 Apr 23. Antimicrob Agents Chemother. 2007. PMID: 17452489 Free PMC article. Clinical Trial.
A dose-dependent elevation of white blood cells (WBC) demonstrated a maximum twofold increase over baseline (95% confidence interval, 2.0- to 2.1-fold) in an E(max) model. In healthy volunteers, AMD070 was well tolerated and demonstrated mixed-order pharmacokinetics, and f …
A dose-dependent elevation of white blood cells (WBC) demonstrated a maximum twofold increase over baseline (95% confidence interval, 2.0- t …
Quantification of the spatial distribution of rectally applied surrogates for microbicide and semen in colon with SPECT and magnetic resonance imaging.
Cao YJ, Caffo BS, Fuchs EJ, Lee LA, Du Y, Li L, Bakshi RP, Macura K, Khan WA, Wahl RL, Grohskopf LA, Hendrix CW. Cao YJ, et al. Br J Clin Pharmacol. 2012 Dec;74(6):1013-22. doi: 10.1111/j.1365-2125.2012.04267.x. Br J Clin Pharmacol. 2012. PMID: 22404308 Free PMC article.
Three novel concentration-distance parameters were defined to describe quantitatively the distribution of radiolabels: maximal distance (D(max) ), distance at maximal concentration (D(Cmax) ) and mean residence distance (D(ave) ). ...Between 1 h and 24 h post dose, the sur …
Three novel concentration-distance parameters were defined to describe quantitatively the distribution of radiolabels: maximal distance (D( …