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Page 1
Molecular basis for substrate recruitment to the PRMT5 methylosome.
Mulvaney KM, Blomquist C, Acharya N, Li R, Ranaghan MJ, O'Keefe M, Rodriguez DJ, Young MJ, Kesar D, Pal D, Stokes M, Nelson AJ, Jain SS, Yang A, Mullin-Bernstein Z, Columbus J, Bozal FK, Skepner A, Raymond D, LaRussa S, McKinney DC, Freyzon Y, Baidi Y, Porter D, Aguirre AJ, Ianari A, McMillan B, Sellers WR. Mulvaney KM, et al. Among authors: mckinney dc. Mol Cell. 2021 Sep 2;81(17):3481-3495.e7. doi: 10.1016/j.molcel.2021.07.019. Epub 2021 Aug 5. Mol Cell. 2021. PMID: 34358446 Free PMC article.
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
McKinney DC, McMillan BJ, Ranaghan MJ, Moroco JA, Brousseau M, Mullin-Bernstein Z, O'Keefe M, McCarren P, Mesleh MF, Mulvaney KM, Robinson F, Singh R, Bajrami B, Wagner FF, Hilgraf R, Drysdale MJ, Campbell AJ, Skepner A, Timm DE, Porter D, Kaushik VK, Sellers WR, Ianari A. McKinney DC, et al. J Med Chem. 2021 Aug 12;64(15):11148-11168. doi: 10.1021/acs.jmedchem.1c00507. Epub 2021 Aug 3. J Med Chem. 2021. PMID: 34342224 Free PMC article.
Novel broad-spectrum inhibitors of bacterial methionine aminopeptidase.
Rose JA, Lahiri SD, McKinney DC, Albert R, Morningstar ML, Shapiro AB, Fisher SL, Fleming PR. Rose JA, et al. Among authors: mckinney dc. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3301-6. doi: 10.1016/j.bmcl.2015.05.061. Epub 2015 May 30. Bioorg Med Chem Lett. 2015. PMID: 26099541
Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform.
Jiang W, Shaw S, Rush J, Dumont N, Kim J, Singh R, Skepner A, Khodier C, Raffier C, Yan N, Schluter C, Yu X, Szuchnicki M, Sathappa M, Kahn J, Sperling AS, McKinney DC, Gould AE, Garvie CW, Miller PG. Jiang W, et al. Among authors: mckinney dc. bioRxiv [Preprint]. 2024 May 21:2024.05.20.595001. doi: 10.1101/2024.05.20.595001. bioRxiv. 2024. PMID: 38826457 Free PMC article. Preprint.
Pyrazolopyrimidines establish MurC as a vulnerable target in Pseudomonas aeruginosa and Escherichia coli.
Hameed P S, Manjrekar P, Chinnapattu M, Humnabadkar V, Shanbhag G, Kedari C, Mudugal NV, Ambady A, de Jonge BL, Sadler C, Paul B, Sriram S, Kaur P, Guptha S, Raichurkar A, Fleming P, Eyermann CJ, McKinney DC, Sambandamurthy VK, Panda M, Ravishankar S. Hameed P S, et al. Among authors: mckinney dc. ACS Chem Biol. 2014 Oct 17;9(10):2274-82. doi: 10.1021/cb500360c. Epub 2014 Aug 5. ACS Chem Biol. 2014. PMID: 25035921
17 results