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52 results

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Page 1
Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1beta/NF-kappaB pathway.
Yu H, Xie M, Meng Z, Lo CY, Chan FL, Jiang L, Meng X, Yao X. Yu H, et al. Br J Cancer. 2021 Nov;125(10):1420-1431. doi: 10.1038/s41416-021-01537-0. Epub 2021 Sep 21. Br J Cancer. 2021. PMID: 34548638 Free PMC article.
Overexpression of MCOLN2 promoted Pca cells proliferation, migration and invasion. Importantly, knockdown of MCOLN2 inhibited Pca xenograft tumor growth and bone lesion development in vivo. ...CONCLUSION: In summary, MCOLN2 is crucially involved in Pca progre …
Overexpression of MCOLN2 promoted Pca cells proliferation, migration and invasion. Importantly, knockdown of MCOLN2 inhibited …
A diverse range of gene products are effectors of the type I interferon antiviral response.
Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM. Schoggins JW, et al. Nature. 2011 Apr 28;472(7344):481-5. doi: 10.1038/nature09907. Epub 2011 Apr 10. Nature. 2011. PMID: 21478870 Free PMC article.
Several ISGs, including ADAR, FAM46C, LY6E and MCOLN2, enhanced the replication of certain viruses, highlighting another layer of complexity in the highly pleiotropic type I interferon system....
Several ISGs, including ADAR, FAM46C, LY6E and MCOLN2, enhanced the replication of certain viruses, highlighting another layer of com …
Human variation impacting MCOLN2 restricts Salmonella Typhi replication by magnesium deprivation.
Gibbs KD, Wang L, Yang Z, Anderson CE, Bourgeois JS, Cao Y, Gaggioli MR, Biel M, Puertollano R, Chen CC, Ko DC. Gibbs KD, et al. Cell Genom. 2023 Apr 4;3(5):100290. doi: 10.1016/j.xgen.2023.100290. eCollection 2023 May 10. Cell Genom. 2023. PMID: 37228749 Free PMC article.
Typhi transcriptomics and manipulation of magnesium availability-demonstrates that the divalent cation channel mucolipin-2 (MCOLN2 or TRPML2) restricts S. Typhi intracellular replication through magnesium deprivation. Mg(2+) currents, conducted through MCOLN2 and ou …
Typhi transcriptomics and manipulation of magnesium availability-demonstrates that the divalent cation channel mucolipin-2 (MCOLN2 or …
TRPML2 and mucolipin evolution.
García-Añoveros J, Wiwatpanit T. García-Añoveros J, et al. Handb Exp Pharmacol. 2014;222:647-58. doi: 10.1007/978-3-642-54215-2_25. Handb Exp Pharmacol. 2014. PMID: 24756724 Review.
The TRPML2 protein, encoded by the Mcoln2 gene, is one of the three mucolipins (TRPML1-3), a subset of the TRP superfamily of ion channels. ...The close homology of TRPML2 and 3 (closer to each other than to TRPML1) suggests that Mcoln2 and Mcoln3 arose from unequal …
The TRPML2 protein, encoded by the Mcoln2 gene, is one of the three mucolipins (TRPML1-3), a subset of the TRP superfamily of ion cha …
Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages.
Chen S, Wang K, Fan Z, Zhou T, Li R, Zhang B, Chen J, Chi J, Wei K, Liu J, Liu Z, Ma J, Dong N, Liu J. Chen S, et al. Mol Med. 2024 Jun 15;30(1):88. doi: 10.1186/s10020-024-00858-z. Mol Med. 2024. PMID: 38879491 Free PMC article.
RESULTS: NaW increases the pH of macrophage lysosome through transmembrane protein 175 (TMEM175) and caused the release of Ca(2+) through the lysosomal Ca(2+) channel mucolipin-2 (Mcoln2). At the same time, the released Ca(2+) activates TFEB, which promotes glucose uptake …
RESULTS: NaW increases the pH of macrophage lysosome through transmembrane protein 175 (TMEM175) and caused the release of Ca(2+) through th …
Transcriptomic profile of the mechanosensitive ion channelome in human cardiac fibroblasts.
Mitrokhin V, Bilichenko A, Kazanski V, Schobik R, Shileiko S, Revkova V, Kalsin V, Kamkina O, Kamkin A, Mladenov M. Mitrokhin V, et al. Exp Biol Med (Maywood). 2023 Dec;248(23):2341-2350. doi: 10.1177/15353702231218488. Epub 2023 Dec 30. Exp Biol Med (Maywood). 2023. PMID: 38158807 Free PMC article.
A strong expression of the TRPC1, TRPC4, TRPC6, and TRPC2 channels and all members of the TRPML subfamily (MCOLN1, MCOLN2, and MCOLN3) was also shown. In terms of the transmembrane protein 16 (TMEM16) family, the HCFs demonstrated significant expression of the TMEM16H, TME …
A strong expression of the TRPC1, TRPC4, TRPC6, and TRPC2 channels and all members of the TRPML subfamily (MCOLN1, MCOLN2, and MCOLN3 …
Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses.
Rinkenberger N, Schoggins JW. Rinkenberger N, et al. mBio. 2018 Jan 30;9(1):e02314-17. doi: 10.1128/mBio.02314-17. mBio. 2018. PMID: 29382735 Free PMC article.
We previously identified endosomal cation channel mucolipin-2 (MCOLN2) as a host factor that promotes viral infection. Here, we assign a role for MCOLN2 in modulating viral entry. We show that MCOLN2 specifically promotes viral vesicular trafficking and subse …
We previously identified endosomal cation channel mucolipin-2 (MCOLN2) as a host factor that promotes viral infection. Here, we assig …
PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene.
Valadez JA, Cuajungco MP. Valadez JA, et al. Gene. 2015 Jan 25;555(2):194-202. doi: 10.1016/j.gene.2014.11.003. Epub 2014 Nov 6. Gene. 2015. PMID: 25445271 Free PMC article.
Thus, we set out to identify the core promoter region and the transcription factor responsible for MCOLN2 gene expression. Using dual-luciferase assay and over-expression analyses, we reveal for the first time that B-cell lineage specific activator protein (BSAP), also kno …
Thus, we set out to identify the core promoter region and the transcription factor responsible for MCOLN2 gene expression. Using dual …
Role of PAX6, TRPA1, BCL11B, MCOLN2, CUX1, EMX1 in colorectal cancer and osteosarcoma.
Zhang J, Gao Q, Hou S, Chi X, Zheng M, Zhang Q, Shan H, Zhang X, Kang C. Zhang J, et al. Medicine (Baltimore). 2024 Feb 2;103(5):e37056. doi: 10.1097/MD.0000000000037056. Medicine (Baltimore). 2024. PMID: 38306561 Free PMC article.
Eight core genes (CUX1, NES, BCL11B, PAX6, EMX1, MCOLN2, TRPA1, TRPC4) were identified. CTD showed that 4 genes (CUX1, EMX1, TRPA1, BCL11B) were associated with colorectal neoplasms, colorectal tumors, colonic diseases, multiple myeloma, OS, and inflammation. PAX6, TRPA1, …
Eight core genes (CUX1, NES, BCL11B, PAX6, EMX1, MCOLN2, TRPA1, TRPC4) were identified. CTD showed that 4 genes (CUX1, EMX1, TRPA1, B …
Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs.
Karacsonyi C, Miguel AS, Puertollano R. Karacsonyi C, et al. Traffic. 2007 Oct;8(10):1404-14. doi: 10.1111/j.1600-0854.2007.00619.x. Epub 2007 Jul 29. Traffic. 2007. PMID: 17662026 Free article.
Expression of a constitutive active Arf6 mutant, or activation of endogenous Arf6 by transfection with EFA6 or treatment with aluminum fluoride, caused accumulation of MCOLN2 in enlarged vacuoles that also contain MHCI and CD59. In addition, overexpression of MCOLN2 …
Expression of a constitutive active Arf6 mutant, or activation of endogenous Arf6 by transfection with EFA6 or treatment with aluminum fluor …
52 results