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Biallelic MED29 variants cause pontocerebellar hypoplasia with cataracts.
Arkush L, van Woerden GM, Ziv L, Marek-Yagel D, Fonseca R, Brevé E, Barel O, Shalva N, Veber A, Anikster Y, Ben-Ami Raichman D, Musallam B, Marcu S, Nissenkorn A, Mandel H, Kushner SA, Ben Zeev B, Heimer G. Arkush L, et al. Eur J Hum Genet. 2025 Oct;33(10):1271-1280. doi: 10.1038/s41431-025-01918-6. Epub 2025 Jul 31. Eur J Hum Genet. 2025. PMID: 40745490 Free PMC article.
Both were homozygous for a c.416T > C, p.(Leu139Pro) MED29 variant which was predicted to be pathogenic. Locomotion and cerebellar GABAergic neurons development were both impaired in MED29 Morpholino-knockdown zebrafish and rescued by human wild-type gene express …
Both were homozygous for a c.416T > C, p.(Leu139Pro) MED29 variant which was predicted to be pathogenic. Locomotion and cerebellar …
CHRDL1 inhibits OSCC metastasis via MAPK signaling-mediated inhibition of MED29.
Huang S, Zhang J, Qiao Y, Pathak JL, Zou R, Piao Z, Xie S, Liang J, Ouyang K. Huang S, et al. Mol Med. 2024 Oct 26;30(1):187. doi: 10.1186/s10020-024-00956-y. Mol Med. 2024. PMID: 39462350 Free PMC article.
Overexpression of MED29 facilitated EMT in OSCC cell lines, whereas knockdown of MED29 impeded EMT, resulting in diminished cell migration and invasion capacities. ...Furthermore, CHRDL1 mediated the inhibition of migration of OSCC cell lines to the OSCC through its …
Overexpression of MED29 facilitated EMT in OSCC cell lines, whereas knockdown of MED29 impeded EMT, resulting in diminished ce …
MED29, a component of the mediator complex, possesses both oncogenic and tumor suppressive characteristics in pancreatic cancer.
Kuuselo R, Savinainen K, Sandström S, Autio R, Kallioniemi A. Kuuselo R, et al. Int J Cancer. 2011 Dec 1;129(11):2553-65. doi: 10.1002/ijc.25924. Epub 2011 Mar 25. Int J Cancer. 2011. PMID: 21225629 Free PMC article.
We previously found that MED29 is amplified and overexpressed in pancreatic cancer and that MED29 silencing leads to decreased cell survival in PANC-1 pancreatic cancer cells with high MED29 expression. Here we further demonstrate decreased migration, invasio …
We previously found that MED29 is amplified and overexpressed in pancreatic cancer and that MED29 silencing leads to decreased …
A novel tRNA-derived fragment AS-tDR-007333 promotes the malignancy of NSCLC via the HSPB1/MED29 and ELK4/MED29 axes.
Yang W, Gao K, Qian Y, Huang Y, Xiang Q, Chen C, Chen Q, Wang Y, Fang F, He Q, Chen S, Xiong J, Chen Y, Xie N, Zheng D, Zhai R. Yang W, et al. J Hematol Oncol. 2022 May 7;15(1):53. doi: 10.1186/s13045-022-01270-y. J Hematol Oncol. 2022. PMID: 35526007 Free PMC article.
Mechanistically, AS-tDR-007333 promoted the malignancy of NSCLC cells by activating MED29 through two distinct mechanisms. First, AS-tDR-007333 bound to and interacted with HSPB1, which activated MED29 expression by enhancing H3K4me1 and H3K27ac in MED29 prom …
Mechanistically, AS-tDR-007333 promoted the malignancy of NSCLC cells by activating MED29 through two distinct mechanisms. First, AS- …
Mediator-29 limits Caenorhabditis elegans fecundity.
Fan Q, Tran C, Cao W, Pocock R. Fan Q, et al. Genetics. 2025 May 8;230(1):iyaf051. doi: 10.1093/genetics/iyaf051. Genetics. 2025. PMID: 40120129 Free PMC article.
Here, we investigated the function of MDT-29/MED29 in the Caenorhabditis elegans germ line. We found that endogenously tagged MDT-29 is ubiquitously expressed and concentrated in discrete foci within germ cell nuclei. ...
Here, we investigated the function of MDT-29/MED29 in the Caenorhabditis elegans germ line. We found that endogenously tagged MDT-29 …
Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins.
Doi S, Fujioka N, Ohtsuka S, Kondo R, Yamamoto M, Denda M, Magari M, Kanayama N, Hatano N, Morishita R, Hasegawa T, Tokumitsu H. Doi S, et al. Cell Calcium. 2021 Jun;96:102404. doi: 10.1016/j.ceca.2021.102404. Epub 2021 Mar 27. Cell Calcium. 2021. PMID: 33831707 Free article.
Among newly discovered putative S100A2 interactants, including TMLHE, TRH, RPL36, MRPS34, CDR2L, OIP5, and MED29, we identified and characterized the tubulin polymerization-promoting protein (TPPP) as a novel S100A2-binding protein. ...
Among newly discovered putative S100A2 interactants, including TMLHE, TRH, RPL36, MRPS34, CDR2L, OIP5, and MED29, we identified and c …
Systematic analysis of the expression profiles and prognostic significance of the MED gene family in renal clear cell carcinoma.
Wang M, Min M, Mai J, Liu X. Wang M, et al. Oncol Lett. 2024 Jun 26;28(2):398. doi: 10.3892/ol.2024.14531. eCollection 2024 Aug. Oncol Lett. 2024. PMID: 38979551 Free PMC article.
Furthermore, according to univariate and multivariate analyses, MED7, MED16, MED21, MED25 and MED29 may be valuable independent predictive biomarkers for the prognosis of individuals with KIRC. ...Additionally, patients with KIRC with high transcription levels of MED7, MED …
Furthermore, according to univariate and multivariate analyses, MED7, MED16, MED21, MED25 and MED29 may be valuable independent predi …
A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.
Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC. Sato S, et al. Mol Cell. 2004 Jun 4;14(5):685-91. doi: 10.1016/j.molcel.2004.05.006. Mol Cell. 2004. PMID: 15175163 Free article.
By comparing MudPIT data sets obtained from six independent Mediator preparations immunoaffinity purified through their Nut2 (MED10), Med25 (MED9), Intersex (MED29), LCMR1 (MED19), AK007855 (MED28), or CRSP70 (MED26) subunits, we identify a set of consensus mammalian Media …
By comparing MudPIT data sets obtained from six independent Mediator preparations immunoaffinity purified through their Nut2 (MED10), Med25 …
Identification of miRNA-mRNA Co-expression by network analysis in dengue virus infection.
Das R, Selvam S, Sinnarasan VSP, Paul D, Sheikh MMR, Venkatesan A. Das R, et al. Virusdisease. 2025 Jun;36(2):285-294. doi: 10.1007/s13337-025-00915-z. Epub 2025 Mar 12. Virusdisease. 2025. PMID: 41018217 Free PMC article.
ROC analysis demonstrated high diagnostic potential for pairs such as TUBA1A-hsa-mir-205-5p, CXCL16-hsa-mir-205-5p, MED29-hsa-mir-148b-5p, PPARA-hsa-mir-3614-5p, and PTPRJ-hsa-mir-96-5p, with Area Under the Curve (AUC) values of 1. ...
ROC analysis demonstrated high diagnostic potential for pairs such as TUBA1A-hsa-mir-205-5p, CXCL16-hsa-mir-205-5p, MED29-hsa-mir-148 …
Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex.
Bourbon HM. Bourbon HM. Nucleic Acids Res. 2008 Jul;36(12):3993-4008. doi: 10.1093/nar/gkn349. Epub 2008 May 31. Nucleic Acids Res. 2008. PMID: 18515835 Free PMC article.
Saccharomyces cerevisiae Med2, Med3/Pgd1 and Med5/Nut1 subunits are apparent homologs of metazoan Med29/Intersex, Med27/Crsp34 and Med24/Trap100, respectively, and these and other 30 identified human MED subunits have detectable counterparts in the amoeba Dictyostelium dis …
Saccharomyces cerevisiae Med2, Med3/Pgd1 and Med5/Nut1 subunits are apparent homologs of metazoan Med29/Intersex, Med27/Crsp34 and Me …
15 results