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GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1.
Zmajkovicova K, Bauer Y, Menyhart K, Schnoebelen M, Freti D, Boucher M, Renault B, Studer R, Birker-Robaczewska M, Klenk A, Nayler O, Gatfield J. Zmajkovicova K, et al. Among authors: menyhart k. PLoS One. 2020 Feb 13;15(2):e0228195. doi: 10.1371/journal.pone.0228195. eCollection 2020. PLoS One. 2020. PMID: 32053631 Free PMC article.
2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.
Bolli MH, Abele S, Binkert C, Bravo R, Buchmann S, Bur D, Gatfield J, Hess P, Kohl C, Mangold C, Mathys B, Menyhart K, Müller C, Nayler O, Scherz M, Schmidt G, Sippel V, Steiner B, Strasser D, Treiber A, Weller T. Bolli MH, et al. Among authors: menyhart k. J Med Chem. 2010 May 27;53(10):4198-211. doi: 10.1021/jm100181s. J Med Chem. 2010. PMID: 20446681
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling.
Sobel K, Menyhart K, Killer N, Renault B, Bauer Y, Studer R, Steiner B, Bolli MH, Nayler O, Gatfield J. Sobel K, et al. Among authors: menyhart k. J Biol Chem. 2013 May 24;288(21):14839-51. doi: 10.1074/jbc.M112.426726. Epub 2013 Apr 15. J Biol Chem. 2013. PMID: 23589284 Free PMC article.