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Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.
Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PRE, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A. Deluigi M, et al. Among authors: merklinger l. Nat Commun. 2022 Jan 19;13(1):382. doi: 10.1038/s41467-021-27911-3. Nat Commun. 2022. PMID: 35046410 Free PMC article.
Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Plückthun A, Brown A, Nasr ML, Wagner G. Zhang M, et al. Among authors: merklinger l. Nat Struct Mol Biol. 2021 Mar;28(3):258-267. doi: 10.1038/s41594-020-00554-6. Epub 2021 Feb 25. Nat Struct Mol Biol. 2021. PMID: 33633398 Free PMC article.
A contextual analysis of the Suicide Surveillance Indicators.
Skinner R, Irvine B, Willams G, Pearson C, Kaur J, Yao X, Merklinger L, Lary T. Skinner R, et al. Among authors: merklinger l. Health Promot Chronic Dis Prev Can. 2017 Aug;37(8):257-260. doi: 10.24095/hpcdp.37.8.05. Health Promot Chronic Dis Prev Can. 2017. PMID: 28800296 Free PMC article. No abstract available.
Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Plückthun A. Deluigi M, et al. Among authors: merklinger l. Sci Adv. 2021 Jan 27;7(5):eabe5504. doi: 10.1126/sciadv.abe5504. Print 2021 Jan. Sci Adv. 2021. PMID: 33571132 Free PMC article.