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Altered regulation of hepatic efflux transporters disrupts acetaminophen disposition in pediatric nonalcoholic steatohepatitis.
Canet MJ, Merrell MD, Hardwick RN, Bataille AM, Campion SN, Ferreira DW, Xanthakos SA, Manautou JE, A-Kader HH, Erickson RP, Cherrington NJ. Canet MJ, et al. Among authors: merrell md. Drug Metab Dispos. 2015 Jun;43(6):829-35. doi: 10.1124/dmd.114.062703. Epub 2015 Mar 18. Drug Metab Dispos. 2015. PMID: 25788542 Free PMC article.
The Nrf2 activator oltipraz also activates the constitutive androstane receptor.
Merrell MD, Jackson JP, Augustine LM, Fisher CD, Slitt AL, Maher JM, Huang W, Moore DD, Zhang Y, Klaassen CD, Cherrington NJ. Merrell MD, et al. Drug Metab Dispos. 2008 Aug;36(8):1716-21. doi: 10.1124/dmd.108.020867. Epub 2008 May 12. Drug Metab Dispos. 2008. PMID: 18474683 Free PMC article.