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287 results

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Page 1
Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy.
Lu QB, Ding Y, Liu Y, Wang ZC, Wu YJ, Niu KM, Li KX, Zhang JR, Sun HJ. Lu QB, et al. J Adv Res. 2023 Sep;51:161-179. doi: 10.1016/j.jare.2022.10.014. Epub 2022 Nov 9. J Adv Res. 2023. PMID: 36334887 Free PMC article.
In parallel, Metrnl OE ameliorated, whereas Metrnl downregulation exacerbated high glucose (HG)-elicited hypertrophy, apoptosis and oxidative damage in primary neonatal rat cardiomyocytes. Antibody-induced blockade of Metrnl eliminated the effects of benefits …
In parallel, Metrnl OE ameliorated, whereas Metrnl downregulation exacerbated high glucose (HG)-elicited hypertrophy, apoptosi …
Metrnl as a secreted protein: Discovery and cardiovascular research.
Miao ZW, Chen J, Chen CX, Zheng SL, Zhao HY, Miao CY. Miao ZW, et al. Pharmacol Ther. 2024 Nov;263:108730. doi: 10.1016/j.pharmthera.2024.108730. Epub 2024 Oct 12. Pharmacol Ther. 2024. PMID: 39401532 Review.
Especially, we show that endothelial Metrnl is a major source for circulating Metrnl levels. Meanwhile, lots of clinical studies have investigated the relationship between blood Metrnl levels and metabolic, inflammatory and cardiovascular diseases. ...In addi …
Especially, we show that endothelial Metrnl is a major source for circulating Metrnl levels. Meanwhile, lots of clinical studi …
Meteorin-like protein/METRNL/Interleukin-41 ameliorates atopic dermatitis-like inflammation.
Huang D, Liu X, Gao X, Choi CK, Giglio G, Farah L, Leung TF, Wong KC, Kan LL, Chong JW, Meng QJ, Liao J, Cheung PF, Wong CK. Huang D, et al. Allergy. 2025 Feb;80(2):474-488. doi: 10.1111/all.16150. Epub 2024 May 10. Allergy. 2025. PMID: 38727640 Free PMC article.
However, how METRNL exerts its regulatory properties on skin inflammation remains elusive. This study aims to elucidate the functionality and regulatory mechanism of METRNL in atopic dermatitis (AD). ...Following repeated MC903 exposure, AD model mice displayed elev …
However, how METRNL exerts its regulatory properties on skin inflammation remains elusive. This study aims to elucidate the functiona …
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B. Zhou Y, et al. Diabetes. 2023 May 1;72(5):611-626. doi: 10.2337/db22-0680. Diabetes. 2023. PMID: 36812572 Free PMC article.
Functionally, pharmacological administration of recombinant Metrnl (rMetrnl) or Metrnl overexpression could alleviate lipid accumulation and inhibit kidney failure. ...Metrnl-specific overexpression in the kidney or recombinant Metrnl administration al …
Functionally, pharmacological administration of recombinant Metrnl (rMetrnl) or Metrnl overexpression could alleviate lipid ac …
Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice.
Hong C, Wang Z, Zheng SL, Hu WJ, Wang SN, Zhao Y, Miao CY. Hong C, et al. Acta Pharmacol Sin. 2023 Apr;44(4):741-751. doi: 10.1038/s41401-022-01009-y. Epub 2022 Oct 13. Acta Pharmacol Sin. 2023. PMID: 36229598 Free PMC article.
In the D-gal-induced aging cell model in vitro, Metrnl levels in the hippocampal astrocytes were significantly increased, and Metrnl knockdown and overexpression regulated the BDNF levels in primary hippocampal astrocytes rather than in neurons. We conclude that …
In the D-gal-induced aging cell model in vitro, Metrnl levels in the hippocampal astrocytes were significantly increased, and Metr …
Metrnl: a promising biomarker and therapeutic target for cardiovascular and metabolic diseases.
Dong WS, Hu C, Hu M, Gao YP, Hu YX, Li K, Ye YJ, Zhang X. Dong WS, et al. Cell Commun Signal. 2024 Aug 5;22(1):389. doi: 10.1186/s12964-024-01767-8. Cell Commun Signal. 2024. PMID: 39103830 Free PMC article. Review.
Modern human society is burdened with the pandemic of cardiovascular and metabolic diseases. Metrnl is a widely distributed secreted protein in the body, involved in regulating glucose and lipid metabolism and maintaining cardiovascular system homeostasis. In this review, …
Modern human society is burdened with the pandemic of cardiovascular and metabolic diseases. Metrnl is a widely distributed secreted …
Metrnl ameliorates myocardial ischemia-reperfusion injury by activating AMPK-mediated M2 macrophage polarization.
Chen DX, Feng YY, Wang HY, Lu CH, Liu DZ, Gong C, Xue Y, Na N, Huang F. Chen DX, et al. Mol Med. 2025 Mar 13;31(1):98. doi: 10.1186/s10020-025-01150-4. Mol Med. 2025. PMID: 40082768 Free PMC article.
Furthermore, Metrnl overexpression promoted M1 to M2 macrophage polarization. In vitro, BMDMs treated with Metrnl shifted towards M2 polarization, characterized by decreased expression of inflammatory cytokines (IL-1beta, MCP-1, TNF-alpha) and increased expression o …
Furthermore, Metrnl overexpression promoted M1 to M2 macrophage polarization. In vitro, BMDMs treated with Metrnl shifted towa …
Metrnl/C-KIT Axis Attenuates Early Brain Injury Following Subarachnoid Hemorrhage by Inhibiting Neuronal Ferroptosis.
Zhou Y, Li J, Yuan Y, Zhang H, Luo X, Wang F, Tao Y, Yue J, Huang L, Wu L, Cao Y, Yu Q, He Q. Zhou Y, et al. CNS Neurosci Ther. 2025 Feb;31(2):e70286. doi: 10.1111/cns.70286. CNS Neurosci Ther. 2025. PMID: 39981761 Free PMC article.
METHODS: Sprague Dawley rats were used to establish the SAH model through endovascular perforation. r-Metrnl was administered intranasally 1 h after SAH. Metrnl shRNA, C-KIT inhibitor ISCK03, AMPK inhibitor dorsomorphin, and Nrf2 inhibitor ML385 were administered in …
METHODS: Sprague Dawley rats were used to establish the SAH model through endovascular perforation. r-Metrnl was administered intrana …
METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARdelta-dependent pathways in skeletal muscle of mice.
Jung TW, Lee SH, Kim HC, Bang JS, Abd El-Aty AM, Hacımüftüoğlu A, Shin YK, Jeong JH. Jung TW, et al. Exp Mol Med. 2018 Sep 13;50(9):1-11. doi: 10.1038/s12276-018-0147-5. Exp Mol Med. 2018. PMID: 30213948 Free PMC article.
Furthermore, METRNL administration rescued glucose intolerance and reduced HFD-induced body weight gain in mice; however, METRNL did not affect calorie intake. METRNL treatment increased AMPK phosphorylation and PPARdelta expression both in differentiated C2C …
Furthermore, METRNL administration rescued glucose intolerance and reduced HFD-induced body weight gain in mice; however, METRNL …
METRNL represses beta-to-alpha cell trans-differentiation to maintain beta cell function under diabetic metabolic stress in mice.
Zhou Y, Hu L, Zhuang R, Song L, Chang X, Liu L, Huang Y, Zhang M, Zheng J, Xu X, Wang T, Guo B. Zhou Y, et al. Diabetologia. 2025 Aug;68(8):1769-1788. doi: 10.1007/s00125-025-06459-7. Epub 2025 Jun 10. Diabetologia. 2025. PMID: 40495021
This study aims to investigate the effects of Metrnl gene deletion in beta cells on islet function and determine whether METRNL-mediated maintenance of islet cell identity is necessary for beta cell compensation in diabetes. ...Pancreatic islets isolated from MET …
This study aims to investigate the effects of Metrnl gene deletion in beta cells on islet function and determine whether METRNL …
287 results