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Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi.
Kalogriopoulos NA, Lopez-Sanchez I, Lin C, Ngo T, Midde KK, Roy S, Aznar N, Murray F, Garcia-Marcos M, Kufareva I, Ghassemian M, Ghosh P. Kalogriopoulos NA, et al. Among authors: midde kk. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28763-28774. doi: 10.1073/pnas.2004699117. Epub 2020 Nov 2. Proc Natl Acad Sci U S A. 2020. PMID: 33139573 Free PMC article.
GIV/Girdin activates Gαi and inhibits Gαs via the same motif.
Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P. Gupta V, et al. Among authors: midde kk. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5721-30. doi: 10.1073/pnas.1609502113. Epub 2016 Sep 12. Proc Natl Acad Sci U S A. 2016. PMID: 27621449 Free PMC article.
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