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MIDN locus structural variants and Parkinson's Disease risk.
Billingsley KJ, Bandres-Ciga S, Ding J, Hernandez D, Gibbs JR, Blauwendraat C; International Parkinson’s Disease Genomics Consortium (IPDGC). Billingsley KJ, et al. Ann Clin Transl Neurol. 2020 Apr;7(4):602-603. doi: 10.1002/acn3.51012. Epub 2020 Mar 24. Ann Clin Transl Neurol. 2020. PMID: 32212230 Free PMC article. No abstract available.
Viable mutations of mouse midnolin suppress B cell malignancies.
Zhong X, Peddada N, Moresco JJ, Wang J, Jiang Y, Rios JJ, Moresco EMY, Choi JH, Beutler B. Zhong X, et al. J Exp Med. 2024 Jun 3;221(6):e20232132. doi: 10.1084/jem.20232132. Epub 2024 Apr 16. J Exp Med. 2024. PMID: 38625151 Free PMC article.
In a genetic screen, we identified two viable missense alleles of the essential gene Midnolin (Midn) that were associated with reductions in peripheral B cells. Causation was confirmed in mice with targeted deletion of four of six MIDN protein isoforms. MIDN …
In a genetic screen, we identified two viable missense alleles of the essential gene Midnolin (Midn) that were associated with reduct …
MIDN: a spacecraft microdosimeter mission.
Pisacane VL, Ziegler JF, Nelson ME, Caylor M, Flake D, Heyen L, Youngborg E, Rosenfeld AB, Cucinotta F, Zaider M, Dicello JF. Pisacane VL, et al. Radiat Prot Dosimetry. 2006;120(1-4):421-6. doi: 10.1093/rpd/nci601. Epub 2006 Jun 18. Radiat Prot Dosimetry. 2006. PMID: 16785245
MIDN (MIcroDosimetry iNstrument) is a payload on the MidSTAR-I spacecraft (Midshipman Space Technology Applications Research) under development at the United States Naval Academy. MIDN is a solid-state system being designed and constructed to measure microdosimetric …
MIDN (MIcroDosimetry iNstrument) is a payload on the MidSTAR-I spacecraft (Midshipman Space Technology Applications Research) under d …
Midnolin is a confirmed genetic risk factor for Parkinson's disease.
Obara Y, Sato H, Nakayama T, Kato T, Ishii K. Obara Y, et al. Ann Clin Transl Neurol. 2019 Nov;6(11):2205-2211. doi: 10.1002/acn3.50914. Epub 2019 Oct 6. Ann Clin Transl Neurol. 2019. PMID: 31588691 Free PMC article.
However, the majority of PD cases are sporadic, and the mechanisms of onset still remain unclear. Previously, we found that Midnolin (MIDN) is associated with PD in a Yamagata (Japan) cohort study and that MIDN regulates neurite outgrowth and Parkin expression in ne …
However, the majority of PD cases are sporadic, and the mechanisms of onset still remain unclear. Previously, we found that Midnolin (MID …
Structural Variants of Midnolin, a Genetic Risk Factor for Parkinson's Disease, in a Yamagata Cohort.
Sato H, Ishii K, Obara Y. Sato H, et al. Biol Pharm Bull. 2023;46(3):379-381. doi: 10.1248/bpb.b22-00776. Biol Pharm Bull. 2023. PMID: 36858566 Free article.
However, the scale of our previous study was not sufficient to identify MIDN structural variants in the ascertained control of Yamagata Prefecture. We, therefore, reanalyzed MIDN variants in 3021 individuals from Yamagata Prefecture to compare with that in our previ …
However, the scale of our previous study was not sufficient to identify MIDN structural variants in the ascertained control of Yamaga …
Insulin Enhances Gene Expression of Midnolin, a Novel Genetic Risk Factor for Parkinson's Disease, via Extracellular Signal-Regulated Kinase, Phosphoinositide 3-Kinase and Multiple Transcription Factors in SH-SY5Y Cells.
Sagehashi N, Obara Y, Maruyama O, Nakagawa T, Hosoi T, Ishii K. Sagehashi N, et al. J Pharmacol Exp Ther. 2022 May;381(2):68-78. doi: 10.1124/jpet.121.001076. Epub 2022 Mar 3. J Pharmacol Exp Ther. 2022. PMID: 35241633
However, the detailed molecular mechanisms of MIDN expression are unknown. We, therefore, investigated the molecular mechanism of MIDN expression in human neuroblastoma SH-SY5Y cells. ...Furthermore, we identified the important region of the MIDN promoter and …
However, the detailed molecular mechanisms of MIDN expression are unknown. We, therefore, investigated the molecular mechanism of …
Midnolin is a novel regulator of parkin expression and is associated with Parkinson's Disease.
Obara Y, Imai T, Sato H, Takeda Y, Kato T, Ishii K. Obara Y, et al. Sci Rep. 2017 Jul 19;7(1):5885. doi: 10.1038/s41598-017-05456-0. Sci Rep. 2017. PMID: 28724963 Free PMC article.
In the present study, we therefore examined the role of MIDN in detail. We found that in PC12 cells, a model of neuronal cells, MIDN localized primarily to the nucleus and intracellular membranes. ...The activity of CRE was reduced following MIDN loss. Overal …
In the present study, we therefore examined the role of MIDN in detail. We found that in PC12 cells, a model of neuronal cells, MI …
Transcriptome Analysis Reveals That Midnolin Regulates mRNA Expression Levels of Multiple Parkinson's Disease Causative Genes.
Obara Y, Ishii K. Obara Y, et al. Biol Pharm Bull. 2018;41(1):20-23. doi: 10.1248/bpb.b17-00663. Biol Pharm Bull. 2018. PMID: 29311479 Free article.
We recently found that 10.5% of sporadic Parkinson's disease (PD) patients lacked one copy of the midnolin (MIDN) gene. In addition, gene knock-down/out of MIDN caused down-regulation of parkin E3 ubiquitin ligase, indicating MIDN to be a novel PD-risk factor …
We recently found that 10.5% of sporadic Parkinson's disease (PD) patients lacked one copy of the midnolin (MIDN) gene. In addition, …
Midnolin, a Genetic Risk Factor for Parkinson's Disease, Promotes Neurite Outgrowth Accompanied by Early Growth Response 1 Activation in PC12 Cells.
Chiba A, Kato C, Nakagawa T, Osaki T, Nakamura K, Norota I, Nagashima M, Hosoi T, Ishii K, Obara Y. Chiba A, et al. Mol Cell Biol. 2024;44(11):516-527. doi: 10.1080/10985549.2024.2399358. Epub 2024 Sep 12. Mol Cell Biol. 2024. PMID: 39264361 Free PMC article.
Parkinson's disease (PD) is an age-related progressive neurodegenerative disease. Previously, we identified midnolin (MIDN) as a genetic risk factor for PD. Although MIDN copy number loss increases the risk of PD, the molecular function of MIDN remains unclea …
Parkinson's disease (PD) is an age-related progressive neurodegenerative disease. Previously, we identified midnolin (MIDN) as a gene …
44 results