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Starting dose selection and dose escalation for oncology small molecule first-in-patient trials: learnings from a survey of FDA-approved drugs.

Mittapalli RK, Yin D, Beaupre D, Palaparthy R. Mittapalli RK, et al. Cancer Chemother Pharmacol. 2021 Jan;87(1):23-30. doi: 10.1007/s00280-020-04202-0. Epub 2020 Nov 25. Cancer Chemother Pharmacol. 2021. PMID: 33237334 Review.

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Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma.

Oberoi RK, Parrish KE, Sio TT, Mittapalli RK, Elmquist WF, Sarkaria JN. Oberoi RK, et al. Among authors: mittapalli rk. Neuro Oncol. 2016 Jan;18(1):27-36. doi: 10.1093/neuonc/nov164. Epub 2015 Sep 10. Neuro Oncol. 2016. PMID: 26359209 Free PMC article. Review.

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Assessment of the Utility of Physiologically-based Pharmacokinetic Model for prediction of Pharmacokinetics in Chinese and Japanese Populations.

Yu Y, Lin J, Muto C, Li Y, Mori Y, Mittapalli RK, Tse S, Liu J, Ge BK, Liu J. Yu Y, et al. Among authors: mittapalli rk. Int J Med Sci. 2021 Sep 24;18(16):3718-3727. doi: 10.7150/ijms.65040. eCollection 2021. Int J Med Sci. 2021. PMID: 34790045 Free PMC article.

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Exploiting nutrient transporters at the blood-brain barrier to improve brain distribution of small molecules.

Mittapalli RK, Manda VK, Adkins CE, Geldenhuys WJ, Lockman PR. Mittapalli RK, et al. Ther Deliv. 2010 Dec;1(6):775-84. doi: 10.4155/tde.10.76. Ther Deliv. 2010. PMID: 22834013 Review.

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Semi-automated rapid quantification of brain vessel density utilizing fluorescent microscopy.

Bohn KA, Adkins CE, Mittapalli RK, Terrell-Hall TB, Mohammad AS, Shah N, Dolan EL, Nounou MI, Lockman PR. Bohn KA, et al. Among authors: mittapalli rk. J Neurosci Methods. 2016 Sep 1;270:124-131. doi: 10.1016/j.jneumeth.2016.06.012. Epub 2016 Jun 16. J Neurosci Methods. 2016. PMID: 27321229 Free PMC article.

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Quantitative Fluorescence Microscopy Measures Vascular Pore Size in Primary and Metastatic Brain Tumors.

Mittapalli RK, Adkins CE, Bohn KA, Mohammad AS, Lockman JA, Lockman PR. Mittapalli RK, et al. Cancer Res. 2017 Jan 15;77(2):238-246. doi: 10.1158/0008-5472.CAN-16-1711. Epub 2016 Nov 4. Cancer Res. 2017. PMID: 27815391 Free PMC article.

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An Integrated Population Pharmacokinetic Model Versus Individual Models of Depatuxizumab Mafodotin, an Anti-EGFR Antibody Drug Conjugate, in Patients With Solid Tumors Likely to Overexpress EGFR.

Mittapalli RK, Stodtmann S, Friedel A, Menon RM, Bain E, Mensing S, Xiong H. Mittapalli RK, et al. J Clin Pharmacol. 2019 Sep;59(9):1225-1235. doi: 10.1002/jcph.1418. Epub 2019 Apr 16. J Clin Pharmacol. 2019. PMID: 30990907 Clinical Trial.

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Population Pharmacokinetics of Upadacitinib Using the Immediate-Release and Extended-Release Formulations in Healthy Subjects and Subjects with Rheumatoid Arthritis: Analyses of Phase I-III Clinical Trials.

Klünder B, Mittapalli RK, Mohamed MF, Friedel A, Noertersheuser P, Othman AA. Klünder B, et al. Among authors: mittapalli rk. Clin Pharmacokinet. 2019 Aug;58(8):1045-1058. doi: 10.1007/s40262-019-00739-3. Clin Pharmacokinet. 2019. PMID: 30945116 Free PMC article. Clinical Trial.

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Development and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability.

Sane R, Mittapalli RK, Elmquist WF. Sane R, et al. Among authors: mittapalli rk. J Pharm Sci. 2013 Apr;102(4):1343-54. doi: 10.1002/jps.23450. Epub 2013 Jan 18. J Pharm Sci. 2013. PMID: 23334925 Free PMC article.

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ABCG2 and ABCB1 Limit the Efficacy of Dasatinib in a PDGF-B-Driven Brainstem Glioma Model.

Mittapalli RK, Chung AH, Parrish KE, Crabtree D, Halvorson KG, Hu G, Elmquist WF, Becher OJ. Mittapalli RK, et al. Mol Cancer Ther. 2016 May;15(5):819-29. doi: 10.1158/1535-7163.MCT-15-0093. Epub 2016 Feb 16. Mol Cancer Ther. 2016. PMID: 26883271 Free PMC article.

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