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68 results

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Page 1
Multimerin-1 and cancer: a review.
Posner MG. Posner MG. Biosci Rep. 2022 Feb 25;42(2):BSR20211248. doi: 10.1042/BSR20211248. Biosci Rep. 2022. PMID: 35132992 Free PMC article. Review.
This raises the questions if a functional role of MMRN1 is being targeted during cancer development, and if MMRN1's differential expression pattern correlates with cancer progression. As a result, it is timely to review the current state of what is known about MM
This raises the questions if a functional role of MMRN1 is being targeted during cancer development, and if MMRN1's differenti …
MMRN1 Facilitates Renal Cell Carcinoma by Activating AMPK/MMPs Axis.
Ye M, Cao J, Ming Z, Xie Y. Ye M, et al. Cancer Med. 2025 Jul;14(13):e71013. doi: 10.1002/cam4.71013. Cancer Med. 2025. PMID: 40583724 Free PMC article.
The overexpression of MMRN1 was found to enhance the proliferation and metastasis of RCC cells, whereas MMRN1 knockout was opposite. ...CONCLUSION: MMRN1 is an oncogene in RCC. MMRN1 activates MMPs through the AMPK pathway to promote the proliferation …
The overexpression of MMRN1 was found to enhance the proliferation and metastasis of RCC cells, whereas MMRN1 knockout was opp …
Analysis of Multimerin 1 (MMRN1) expression in ovarian cancer.
Saini A, Chandra KB, Kumar V, Mathur SR, Sharma JB, Kumar S, Yadav S. Saini A, et al. Mol Biol Rep. 2020 Dec;47(12):9459-9468. doi: 10.1007/s11033-020-06027-9. Epub 2020 Dec 1. Mol Biol Rep. 2020. PMID: 33263168
Saliva is a clinically informative unique fluid, which is useful for novel approaches to prognosis, clinical diagnosis, and monitoring for non-invasive detection of disease. Multimerin1 (MMRN1) is a di-sulfide linked homo-polymeric glycoprotein from EMILIN family. Altered …
Saliva is a clinically informative unique fluid, which is useful for novel approaches to prognosis, clinical diagnosis, and monitoring for n …
Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion.
Yue M, Hu J, Min X, Xu H. Yue M, et al. Int J Clin Exp Pathol. 2023 Sep 15;16(9):252-258. eCollection 2023. Int J Clin Exp Pathol. 2023. PMID: 37818386 Free PMC article.
Next-generation sequencing (NGS) revealed a GATAD2B::MMRN1 rearrangement. The patient was diagnosed with uterine sarcoma resembling high-grade endometrial mesenchymal sarcoma with a GATAD2B-MMRN1 fusion. ...
Next-generation sequencing (NGS) revealed a GATAD2B::MMRN1 rearrangement. The patient was diagnosed with uterine sarcoma resembling h …
Endoplasmic reticulum stress-MMRN1 positive feedback contributes to cisplatin resistance in small cell lung cancer.
Liu M, Hu P, Tang B, Yang Q, Xiang R, Liu Y, Li J, Wu B, Wu H, Tian B, Xu C, Li Q. Liu M, et al. J Thorac Dis. 2024 Dec 31;16(12):8363-8378. doi: 10.21037/jtd-24-1477. Epub 2024 Dec 28. J Thorac Dis. 2024. PMID: 39831245 Free PMC article.
Reduction of MMRN1 recovered the sensitivity to CDDP while overexpression of MMRN1 conferred CDDP resistance. The CDDP-resistant SCLC cells disseminated resistant to the CDDP-sensitive SCLC cells via the exosomal MMRN1. Additionally, CDDP treatment induces en …
Reduction of MMRN1 recovered the sensitivity to CDDP while overexpression of MMRN1 conferred CDDP resistance. The CDDP-resista …
Investigation of the genetic aetiology of Lewy body diseases with and without dementia.
Wu LY, Real R, Martinez-Carrasco A, Chia R, Lawton MA, Shoai M, Bresner C, Blauwendraat C, Singleton AB, Ryten M; International Lewy Body Dementia Genomics Consortium; Scholz SW, Traynor BJ, Williams NM, Hu MTM, Ben-Shlomo Y, Grosset DG, Hardy J, Morris HR. Wu LY, et al. Brain Commun. 2024 May 31;6(4):fcae190. doi: 10.1093/braincomms/fcae190. eCollection 2024. Brain Commun. 2024. PMID: 38978726 Free PMC article.
We found that risk allele rs429358 tagging APOEe4 increases the odds of developing dementia, and that rs7668531 near the MMRN1 and SNCA-AS1 genes and an intronic variant rs17442721 tagging LRRK2 G2019S on chromosome 12 are protective against dementia. ...
We found that risk allele rs429358 tagging APOEe4 increases the odds of developing dementia, and that rs7668531 near the MMRN1 and SN …
Multimerin-1 (MMRN1) as Novel Adverse Marker in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group.
Laszlo GS, Alonzo TA, Gudgeon CJ, Harrington KH, Gerbing RB, Wang YC, Ries RE, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S, Walter RB. Laszlo GS, et al. Clin Cancer Res. 2015 Jul 15;21(14):3187-95. doi: 10.1158/1078-0432.CCR-14-2684. Epub 2015 Mar 30. Clin Cancer Res. 2015. PMID: 25825478 Free PMC article.
PURPOSE: Exploratory gene expression array analyses suggested multimerin-1 (MMRN1) to be a predictive biomarker in acute myelogenous leukemia (AML). Following up on these studies, we evaluated the role of MMRN1 expression as outcome predictor in two recent Children' …
PURPOSE: Exploratory gene expression array analyses suggested multimerin-1 (MMRN1) to be a predictive biomarker in acute myelogenous …
The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.
Parker DN, Tasneem S, Farndale RW, Bihan D, Sadler JE, Sebastian S, de Groot PG, Hayward CP. Parker DN, et al. Thromb Haemost. 2016 Jul 4;116(1):87-95. doi: 10.1160/TH15-09-0700. Epub 2016 Apr 7. Thromb Haemost. 2016. PMID: 27052467 Free PMC article.
VWF associates with MMRN1 at high shear, not static conditions, suggesting that shear exposes cryptic sites within VWF that support MMRN1 binding. Modified ELISA and surface plasmon resonance were used to study the structural features of VWF that support MMRN1
VWF associates with MMRN1 at high shear, not static conditions, suggesting that shear exposes cryptic sites within VWF that support …
Multimerin 1 supports platelet function in vivo and binds to specific GPAGPOGPX motifs in fibrillar collagens that enhance platelet adhesion.
Leatherdale A, Parker D, Tasneem S, Wang Y, Bihan D, Bonna A, Hamaia SW, Gross PL, Ni H, Doble BW, Lillicrap D, Farndale RW, Hayward CPM. Leatherdale A, et al. J Thromb Haemost. 2021 Feb;19(2):547-561. doi: 10.1111/jth.15171. Epub 2020 Dec 17. J Thromb Haemost. 2021. PMID: 33179420 Free PMC article.
OBJECTIVES: To examine the impact of Mmrn1 deficiency on platelet adhesive function, and the molecular motifs in fibrillar collagen that bind MMRN1 to enhance platelet adhesion. ...Mmrn1(-/-) and Mmrn1(+/-) mice were viable and fertile, with complete a …
OBJECTIVES: To examine the impact of Mmrn1 deficiency on platelet adhesive function, and the molecular motifs in fibrillar collagen t …
Proteomic profiling of human plasma extracellular vesicles identifies PF4 and C1R as novel biomarker in sarcopenia.
Aparicio P, Navarrete-Villanueva D, Gómez-Cabello A, López-Royo T, Santamaría E, Fernández-Irigoyen J, Ausín K, Arruebo M, Sebastian V, Vicente-Rodríguez G, Osta R, Manzano R. Aparicio P, et al. J Cachexia Sarcopenia Muscle. 2024 Oct;15(5):1883-1897. doi: 10.1002/jcsm.13539. Epub 2024 Jul 15. J Cachexia Sarcopenia Muscle. 2024. PMID: 39009419 Free PMC article.
Statistical analysis revealed eight proteins whose concentration was significantly different between groups: PF4 (log2 FC = 4.806), OIT3 (log2 FC = -1.161), MMRN1 (log2 FC = -1.982), MASP1 (log2 FC = -0.627), C1R (log2 FC = 1.830), SVEP1 (log2 FC = 1.295), VCAN (FC = 0.937 …
Statistical analysis revealed eight proteins whose concentration was significantly different between groups: PF4 (log2 FC = 4.806), OIT3 (lo …
68 results