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A cryptic pocket in Ebola VP35 allosterically controls RNA binding.
Nat Commun. 2022 Apr 27;13(1):2269. doi: 10.1038/s41467-022-29927-9.
Nat Commun. 2022.
PMID: 35477718
Free PMC article.
Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators.
Hart KM, Moeder KE, Ho CMW, Zimmerman MI, Frederick TE, Bowman GR.
Hart KM, et al. Among authors: moeder ke.
PLoS One. 2017 Jun 1;12(6):e0178678. doi: 10.1371/journal.pone.0178678. eCollection 2017.
PLoS One. 2017.
PMID: 28570708
Free PMC article.
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Cooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling.
Porter JR, Moeder KE, Sibbald CA, Zimmerman MI, Hart KM, Greenberg MJ, Bowman GR.
Porter JR, et al. Among authors: moeder ke.
Biophys J. 2019 Mar 5;116(5):818-830. doi: 10.1016/j.bpj.2018.11.3144. Epub 2019 Jan 25.
Biophys J. 2019.
PMID: 30744991
Free PMC article.
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