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Roles of the M₄ acetylcholine receptor in the basal ganglia and the treatment of movement disorders.

Moehle MS, Conn PJ. Moehle MS, et al. Mov Disord. 2019 Aug;34(8):1089-1099. doi: 10.1002/mds.27740. Epub 2019 Jun 18. Mov Disord. 2019. PMID: 31211471 Free PMC article. Review.

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M1 and M2 immune activation in Parkinson's Disease: Foe and ally?

Moehle MS, West AB. Moehle MS, et al. Neuroscience. 2015 Aug 27;302:59-73. doi: 10.1016/j.neuroscience.2014.11.018. Epub 2014 Nov 25. Neuroscience. 2015. PMID: 25463515 Free PMC article. Review.

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α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration.

Abdelmotilib H, Maltbie T, Delic V, Liu Z, Hu X, Fraser KB, Moehle MS, Stoyka L, Anabtawi N, Krendelchtchikova V, Volpicelli-Daley LA, West A. Abdelmotilib H, et al. Among authors: moehle ms. Neurobiol Dis. 2017 Sep;105:84-98. doi: 10.1016/j.nbd.2017.05.014. Epub 2017 May 30. Neurobiol Dis. 2017. PMID: 28576704 Free PMC article.

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LRRK2 inhibition attenuates microglial inflammatory responses.

Moehle MS, Webber PJ, Tse T, Sukar N, Standaert DG, DeSilva TM, Cowell RM, West AB. Moehle MS, et al. J Neurosci. 2012 Feb 1;32(5):1602-11. doi: 10.1523/JNEUROSCI.5601-11.2012. J Neurosci. 2012. PMID: 22302802 Free PMC article.

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Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.

Daher JP, Volpicelli-Daley LA, Blackburn JP, Moehle MS, West AB. Daher JP, et al. Among authors: moehle ms. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9289-94. doi: 10.1073/pnas.1403215111. Epub 2014 Jun 9. Proc Natl Acad Sci U S A. 2014. PMID: 24927544 Free PMC article.

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Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S LRRK2 carriers.

Fraser KB, Moehle MS, Alcalay RN, West AB; LRRK2 Cohort Consortium. Fraser KB, et al. Among authors: moehle ms. Neurology. 2016 Mar 15;86(11):994-9. doi: 10.1212/WNL.0000000000002436. Epub 2016 Feb 10. Neurology. 2016. PMID: 26865512 Free PMC article.

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Activation of the mGlu₁ metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M₄ muscarinic receptor allosteric modulators.

Yohn SE, Foster DJ, Covey DP, Moehle MS, Galbraith J, Garcia-Barrantes PM, Cho HP, Bubser M, Blobaum AL, Joffe ME, Cheer JF, Jones CK, Lindsley CW, Conn PJ. Yohn SE, et al. Among authors: moehle ms. Mol Psychiatry. 2020 Nov;25(11):2786-2799. doi: 10.1038/s41380-018-0206-2. Epub 2018 Aug 16. Mol Psychiatry. 2020. PMID: 30116027 Free PMC article.

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LRRK2 secretion in exosomes is regulated by 14-3-3.

Fraser KB, Moehle MS, Daher JP, Webber PJ, Williams JY, Stewart CA, Yacoubian TA, Cowell RM, Dokland T, Ye T, Chen D, Siegal GP, Galemmo RA, Tsika E, Moore DJ, Standaert DG, Kojima K, Mobley JA, West AB. Fraser KB, et al. Among authors: moehle ms. Hum Mol Genet. 2013 Dec 15;22(24):4988-5000. doi: 10.1093/hmg/ddt346. Epub 2013 Jul 25. Hum Mol Genet. 2013. PMID: 23886663 Free PMC article.

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Regional differences in expression of β-tubulin isoforms in schizophrenia.

Moehle MS, Luduena RF, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE. Moehle MS, et al. Schizophr Res. 2012 Mar;135(1-3):181-6. doi: 10.1016/j.schres.2011.12.010. Epub 2012 Jan 20. Schizophr Res. 2012. PMID: 22264600 Free PMC article.

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Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M₄ Muscarinic Receptor.

Moehle MS, Pancani T, Byun N, Yohn SE, Wilson GH 3rd, Dickerson JW, Remke DH, Xiang Z, Niswender CM, Wess J, Jones CK, Lindsley CW, Rook JM, Conn PJ. Moehle MS, et al. Neuron. 2017 Dec 20;96(6):1358-1372.e4. doi: 10.1016/j.neuron.2017.12.008. Neuron. 2017. PMID: 29268098 Free PMC article.

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