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The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

González-Cano R, Montilla-García Á, Ruiz-Cantero MC, Bravo-Caparrós I, Tejada MÁ, Nieto FR, Cobos EJ. González-Cano R, et al. Among authors: montilla garcia a. Neurosci Biobehav Rev. 2020 Jun;113:238-261. doi: 10.1016/j.neubiorev.2020.03.004. Epub 2020 Mar 5. Neurosci Biobehav Rev. 2020. PMID: 32147529 Review.

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Targeting immune-driven opioid analgesia by sigma-1 receptors: Opening the door to novel perspectives for the analgesic use of sigma-1 antagonists.

Tejada MÁ, Montilla-García Á, González-Cano R, Bravo-Caparrós I, Ruiz-Cantero MC, Nieto FR, Cobos EJ. Tejada MÁ, et al. Among authors: montilla garcia a. Pharmacol Res. 2018 May;131:224-230. doi: 10.1016/j.phrs.2018.02.008. Epub 2018 Feb 15. Pharmacol Res. 2018. PMID: 29454675 Review.

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Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation.

Montilla-García Á, Tejada MÁ, Ruiz-Cantero MC, Bravo-Caparrós I, Yeste S, Zamanillo D, Cobos EJ. Montilla-García Á, et al. Front Pharmacol. 2019 Feb 22;10:136. doi: 10.3389/fphar.2019.00136. eCollection 2019. Front Pharmacol. 2019. PMID: 30853912 Free PMC article.

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Modality-specific peripheral antinociceptive effects of μ-opioid agonists on heat and mechanical stimuli: Contribution of sigma-1 receptors.

Montilla-García Á, Perazzoli G, Tejada MÁ, González-Cano R, Sánchez-Fernández C, Cobos EJ, Baeyens JM. Montilla-García Á, et al. Neuropharmacology. 2018 Jun;135:328-342. doi: 10.1016/j.neuropharm.2018.03.025. Epub 2018 Mar 24. Neuropharmacology. 2018. PMID: 29580951 Free article.

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Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice.

Tejada MA, Montilla-García A, Cronin SJ, Cikes D, Sánchez-Fernández C, González-Cano R, Ruiz-Cantero MC, Penninger JM, Vela JM, Baeyens JM, Cobos EJ. Tejada MA, et al. Among authors: montilla garcia a. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8396-8401. doi: 10.1073/pnas.1620068114. Epub 2017 Jul 17. Proc Natl Acad Sci U S A. 2017. PMID: 28716934 Free PMC article.

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(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties.

Amata E, Rescifina A, Prezzavento O, Arena E, Dichiara M, Pittalà V, Montilla-García Á, Punzo F, Merino P, Cobos EJ, Marrazzo A. Amata E, et al. Among authors: montilla garcia a. J Med Chem. 2018 Jan 11;61(1):372-384. doi: 10.1021/acs.jmedchem.7b01584. Epub 2017 Dec 20. J Med Chem. 2018. PMID: 29220177

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Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors.

Gonzalez-Cano R, Montilla-García Á, Perazzoli G, Torres JM, Cañizares FJ, Fernández-Segura E, Costigan M, Baeyens JM, Cobos EJ. Gonzalez-Cano R, et al. Among authors: montilla garcia a. Front Pharmacol. 2021 Jan 21;11:613068. doi: 10.3389/fphar.2020.613068. eCollection 2020. Front Pharmacol. 2021. PMID: 33551815 Free PMC article.

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Modulation of peripheral μ-opioid analgesia by σ1 receptors.

Sánchez-Fernández C, Montilla-García Á, González-Cano R, Nieto FR, Romero L, Artacho-Cordón A, Montes R, Fernández-Pastor B, Merlos M, Baeyens JM, Entrena JM, Cobos EJ. Sánchez-Fernández C, et al. Among authors: montilla garcia a. J Pharmacol Exp Ther. 2014 Jan;348(1):32-45. doi: 10.1124/jpet.113.208272. Epub 2013 Oct 23. J Pharmacol Exp Ther. 2014. PMID: 24155346

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Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia.

Montilla-García Á, Tejada MÁ, Perazzoli G, Entrena JM, Portillo-Salido E, Fernández-Segura E, Cañizares FJ, Cobos EJ. Montilla-García Á, et al. Neuropharmacology. 2017 Oct;125:231-242. doi: 10.1016/j.neuropharm.2017.07.029. Epub 2017 Jul 29. Neuropharmacology. 2017. PMID: 28760650 Free article.

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The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene.

Luna-Sánchez M, Díaz-Casado E, Barca E, Tejada MÁ, Montilla-García Á, Cobos EJ, Escames G, Acuña-Castroviejo D, Quinzii CM, López LC. Luna-Sánchez M, et al. Among authors: montilla garcia a. EMBO Mol Med. 2015 May;7(5):670-87. doi: 10.15252/emmm.201404632. EMBO Mol Med. 2015. PMID: 25802402 Free PMC article.

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