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A transcriptome-wide association study identified susceptibility genes for hepatocellular carcinoma in East Asia.
Zhang J, Zhang Q, Hu W, Liang Y, Jiang D, Chen H. Zhang J, et al. Gastroenterol Rep (Oxf). 2024 Jun 5;12:goae057. doi: 10.1093/gastro/goae057. eCollection 2024. Gastroenterol Rep (Oxf). 2024. PMID: 38846986 Free PMC article.
Among the genes identified through TWAS, a significant proportion of them exhibit a credible role in HCC biology, such as FAM96B, HSPA5, POLRMT, MPHOSPH10, and RABL2A. HLA-DQA1, NUAK2, and HSPA5 associated with the process of carcinogenesis in HCC as previously reported. . …
Among the genes identified through TWAS, a significant proportion of them exhibit a credible role in HCC biology, such as FAM96B, HSPA5, POL …
Artificial intelligence-assisted RNA-binding protein signature for prognostic stratification and therapeutic guidance in breast cancer.
Zhao Y, Li L, Yuan S, Meng Z, Xu J, Cai Z, Zhang Y, Zhang X, Wang T. Zhao Y, et al. Front Immunol. 2025 Apr 16;16:1583103. doi: 10.3389/fimmu.2025.1583103. eCollection 2025. Front Immunol. 2025. PMID: 40308601 Free PMC article.
The AIRS model, built on three key RBP genes (PGK1, MPHOSPH10, MAP2K6), stratified patients into high- and low-risk groups. Genomic alterations, single-cell transcriptomics, tumor microenvironment characteristics, and drug sensitivity were assessed to uncover AIRS-associat …
The AIRS model, built on three key RBP genes (PGK1, MPHOSPH10, MAP2K6), stratified patients into high- and low-risk groups. Genomic a …
Genetics of early-onset Parkinson's disease in Finland: exome sequencing and genome-wide association study.
Siitonen A, Nalls MA, Hernández D, Gibbs JR, Ding J, Ylikotila P, Edsall C, Singleton A, Majamaa K. Siitonen A, et al. Neurobiol Aging. 2017 May;53:195.e7-195.e10. doi: 10.1016/j.neurobiolaging.2017.01.019. Epub 2017 Feb 2. Neurobiol Aging. 2017. PMID: 28256260 Free PMC article.
Exome-wide gene-based association tests also identified the MPHOSPH10, TAS2R19, and SERPINA1 genes in the discovery data set (p < 2.5E-6). MPHOSPH10 had estimated odds ratio (OR) of 1.53, and the rs141620200 variant in SERPINA1 had OR of 1.27. ...
Exome-wide gene-based association tests also identified the MPHOSPH10, TAS2R19, and SERPINA1 genes in the discovery data set (p < …
Panax ginseng increases hypoxia-induced down-regulated cellular response related genes in human neuroblastoma cells, SK-N-MC.
Park H, Kim H, Ha E, Yoon S, Kim MJ, Hong M, Leem KH, Hong SJ, Yang J, Chung JH. Park H, et al. Neurol Res. 2007;29 Suppl 1:S78-87. doi: 10.1179/016164107X172338. Neurol Res. 2007. PMID: 17359646
In cDNA microarray analysis, hypoxia remarkably down-regulated IGF-II mRNA-binding protein 3 (IMP-3), integrin alpha 2 (ITGA2), syndecan binding protein (SDCBP), insulin-like growth factor binding protein 3 (IGBP3) and M-phase phosphoprotein 10 (MPHOSPH10), belonging to ca …
In cDNA microarray analysis, hypoxia remarkably down-regulated IGF-II mRNA-binding protein 3 (IMP-3), integrin alpha 2 (ITGA2), syndecan bin …