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26 results

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Page 1
IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci.
International Multiple Sclerosis Genetics Conssortium (IMSGC). International Multiple Sclerosis Genetics Conssortium (IMSGC). Genes Immun. 2010 Jul;11(5):397-405. doi: 10.1038/gene.2010.28. Epub 2010 Jun 17. Genes Immun. 2010. PMID: 20555355 Free PMC article.
Three loci exceeded genome-wide significance in the joint analysis: RGS1 (P value=3.55 x 10(-9)), IL12A (P=3.08 x 10(-8)) and MPHOSPH9/CDK2AP1 (P=3.96 x 10(-8)). The RGS1 risk allele is shared with celiac disease (CD), and the IL12A risk allele seems to be protective for c …
Three loci exceeded genome-wide significance in the joint analysis: RGS1 (P value=3.55 x 10(-9)), IL12A (P=3.08 x 10(-8)) and MPHOSPH9 …
Unveiling the genetic overlap and causal links between gastroesophageal reflux disease and asthma.
Zhang Y, Li Y, Huang W, Tong S, Zeng R, Lyu Y, Leung FW, Chen K, Sha W, Chen H. Zhang Y, et al. Int J Surg. 2025 Dec 1;111(12):9012-9022. doi: 10.1097/JS9.0000000000003283. Epub 2025 Sep 12. Int J Surg. 2025. PMID: 40932390 Free PMC article.
Gene-level analyses pinpointed three novel shared genes ( RBM6, SUOX , and MPHOSPH9 ) between GERD and asthma. scRNA-seq analysis uncovered heightened expression of these genes in immune cells of patients diagnosed with GERD. ...
Gene-level analyses pinpointed three novel shared genes ( RBM6, SUOX , and MPHOSPH9 ) between GERD and asthma. scRNA-seq analysis unc …
M-Phase Phosphoprotein 9 upregulation associates with poor prognosis and activates mTOR signaling in gastric cancer.
Xu LL, Shang Y, Qu XN, He HM. Xu LL, et al. Kaohsiung J Med Sci. 2021 Mar;37(3):208-214. doi: 10.1002/kjm2.12319. Epub 2020 Nov 10. Kaohsiung J Med Sci. 2021. PMID: 33174370 Free PMC article.
In addition, Kaplan-Meier estimates showed gastric cancer patients with high MPHOSPH9 level predicted a poor prognosis. Then, Western blot and CCK-8 assay showed overexpressed MPHOSPH9 enhanced gastric cancer cell proliferation, but MPHOSPH9 knockdown suppres …
In addition, Kaplan-Meier estimates showed gastric cancer patients with high MPHOSPH9 level predicted a poor prognosis. Then, Western …
RNA-seq reveals a novel porcine lncRNA MPHOSPH9-OT1 induces CXCL8/IL-8 expression in ETEC infected IPEC-J2 cells.
Jiang B, Liu M, Li P, Zhu Y, Liu Y, Zhu K, Zuo Y, Li Y. Jiang B, et al. Front Cell Infect Microbiol. 2022 Aug 25;12:996841. doi: 10.3389/fcimb.2022.996841. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36093177 Free PMC article.
Functional and KEGG enrichment analysis of predicted target genes of DE lncRNAs indicated they are enriched in cell growth and inflammation-related pathways, such as endocytosis, focal adhesion, TGF-beta signaling pathway, and adherens junctions. We revealed a novel candidate lnc …
Functional and KEGG enrichment analysis of predicted target genes of DE lncRNAs indicated they are enriched in cell growth and inflammation- …
Predictive value of abnormal expression of MPHOSPH9 in reintervention after high intensity focused ultrasound treatment of uterine fibroids.
Wang J, Xie Y, Zeng C, Nie L, Yang Y. Wang J, et al. J Obstet Gynaecol Res. 2025 Jan;51(1):e16205. doi: 10.1111/jog.16205. J Obstet Gynaecol Res. 2025. PMID: 39780408
AIMS: Aberrantly expressed MPHOSPH9 has been reported to be associated with poor prognosis in many diseases. Previous study indicates that MPHOSPH9 is abnormally expressed in patients with uterine fibroids (UFs). ...They volunteered blood samples before HIFU treatme …
AIMS: Aberrantly expressed MPHOSPH9 has been reported to be associated with poor prognosis in many diseases. Previous study indicates …
Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein.
Bevacqua RJ, Zhao W, Merheb E, Kim SH, Marson A, Gloyn AL, Kim SK. Bevacqua RJ, et al. iScience. 2023 Dec 8;27(1):108693. doi: 10.1016/j.isci.2023.108693. eCollection 2024 Jan 19. iScience. 2023. PMID: 38205242 Free PMC article.
CRISPR-Cas9 RNP approaches revealed genetic targets of regulation by DNA elements containing candidate diabetes risk SNPs, including an in vivo enhancer of the MPHOSPH9 gene. CRISPR-Cas9 RNP multiplexed targeting of two cis-regulatory elements linked to diabetes risk in PC …
CRISPR-Cas9 RNP approaches revealed genetic targets of regulation by DNA elements containing candidate diabetes risk SNPs, including an in v …
Brain eQTLs of European, African American, and Asian ancestry improve interpretation of schizophrenia GWAS.
Chen Y, Liu S, Ren Z, Wang F, Jiang Y, Dai R, Duan F, Han C, Ning Z, Xia Y, Li M, Yuan K, Qiu W, Yan XX, Dai J, Kopp RF, Huang J, Xu S, Tang B, Gamazon ER, Bigdeli T, Gershon E, Huang H, Ma C, Liu C, Chen C. Chen Y, et al. medRxiv [Preprint]. 2024 Feb 16:2024.02.13.24301833. doi: 10.1101/2024.02.13.24301833. medRxiv. 2024. Update in: Am J Hum Genet. 2024 Nov 7;111(11):2444-2457. doi: 10.1016/j.ajhg.2024.09.001. PMID: 38405973 Free PMC article. Updated. Preprint.
Prioritization analysis identified seven new risk genes ( SFXN2 , RP11-282018.3 , CYP17A1 , VPS37B , DENR , FTCDNL1 , and NT5DC2 ), and three potential novel regulatory variants in known risk genes ( CNNM2 , C12orf65 , and MPHOSPH9 ) that were missed in the EUR dataset. Ou …
Prioritization analysis identified seven new risk genes ( SFXN2 , RP11-282018.3 , CYP17A1 , VPS37B , DENR , FTCDNL1 , and NT5DC2 ), and thre …
Cross-ancestry analysis of brain QTLs enhances interpretation of schizophrenia genome-wide association studies.
Chen Y, Liu S, Ren Z, Wang F, Liang Q, Jiang Y, Dai R, Duan F, Han C, Ning Z, Xia Y, Li M, Yuan K, Qiu W, Yan XX, Dai J, Kopp RF, Huang J, Xu S, Tang B, Wu L, Gamazon ER, Bigdeli T, Gershon E, Huang H, Ma C, Liu C, Chen C. Chen Y, et al. Am J Hum Genet. 2024 Nov 7;111(11):2444-2457. doi: 10.1016/j.ajhg.2024.09.001. Epub 2024 Oct 2. Am J Hum Genet. 2024. PMID: 39362218 Free PMC article.
Prioritization analysis identified five risk genes (SFXN2, VPS37B, DENR, FTCDNL1, and NT5DC2) and three potential regulatory variants in known risk genes (CNNM2, MTRFR, and MPHOSPH9) that were missed in the EUR dataset. Our findings underscore that increasing genetic ances …
Prioritization analysis identified five risk genes (SFXN2, VPS37B, DENR, FTCDNL1, and NT5DC2) and three potential regulatory variants in kno …
Evolutionary forces in diabetes and hypertension pathogenesis in Africans.
Meeks KAC, Bentley AR, Adeyemo AA, Rotimi CN. Meeks KAC, et al. Hum Mol Genet. 2021 Apr 26;30(R1):R110-R118. doi: 10.1093/hmg/ddaa238. Hum Mol Genet. 2021. PMID: 33734377 Free PMC article. Review.
Evidence for selection effects on insulin action, including insulin resistance and secretion, has been found for several genes including MPHOSPH9, TMEM127, ZRANB3 and MC3R. These effects may have been historically adaptive in critical conditions, such as famine and inflamm …
Evidence for selection effects on insulin action, including insulin resistance and secretion, has been found for several genes including …
Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels.
Danjou F, Zoledziewska M, Sidore C, Steri M, Busonero F, Maschio A, Mulas A, Perseu L, Barella S, Porcu E, Pistis G, Pitzalis M, Pala M, Menzel S, Metrustry S, Spector TD, Leoni L, Angius A, Uda M, Moi P, Thein SL, Galanello R, Abecasis GR, Schlessinger D, Sanna S, Cucca F. Danjou F, et al. Nat Genet. 2015 Nov;47(11):1264-71. doi: 10.1038/ng.3307. Epub 2015 Sep 14. Nat Genet. 2015. PMID: 26366553 Free PMC article.
Five signals are due to variants at previously undetected loci: MPHOSPH9, PLTP-PCIF1, ZFPM1 (FOG1), NFIX and CCND3. Among the signals at known loci, ten are new lead variants and four are new independent signals. ...
Five signals are due to variants at previously undetected loci: MPHOSPH9, PLTP-PCIF1, ZFPM1 (FOG1), NFIX and CCND3. Among the signals …
26 results