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Did you mean mrnp (1,781 results)?
MRNIP condensates promote DNA double-strand break sensing and end resection.
Wang YL, Zhao WW, Bai SM, Feng LL, Bie SY, Gong L, Wang F, Wei MB, Feng WX, Pang XL, Qin CL, Yin XK, Wang YN, Zhou W, Wahl DR, Liu Q, Chen M, Hung MC, Wan XB. Wang YL, et al. Nat Commun. 2022 May 12;13(1):2638. doi: 10.1038/s41467-022-30303-w. Nat Commun. 2022. PMID: 35551189 Free PMC article.
The intrinsically disordered region is essential for MRNIP condensate formation. Mechanically, the MRN complex is compartmentalized and concentrated into MRNIP condensates in the nucleus. ...Meanwhile, MRNIP condensates-enhanced MRN complex loading further pr …
The intrinsically disordered region is essential for MRNIP condensate formation. Mechanically, the MRN complex is compartmentalized a …
MRNIP limits ssDNA gaps during replication stress.
Bennett LG, Vernon EG, Thanendran V, Jones CM, Gamble A, Staples CJ. Bennett LG, et al. Nucleic Acids Res. 2024 Aug 12;52(14):8320-8331. doi: 10.1093/nar/gkae546. Nucleic Acids Res. 2024. PMID: 38917325 Free PMC article.
MRNIP-deficient cells are sensitive to PARP inhibition and accumulate PRIMPOL-dependent DNA damage, supportive of a pro-survival role for MRNIP linked to the regulation of gap prevalence. In MRNIP-deficient cells, post-replicative gap filling is driven in S-p …
MRNIP-deficient cells are sensitive to PARP inhibition and accumulate PRIMPOL-dependent DNA damage, supportive of a pro-survival role …
MRNIP is essential for meiotic progression and spermatogenesis in mice.
Lin M, Lv J, Zhao D, Liu S, Xu J, Wu Y, Wang F, Zhang J, Zheng B, Shen C, Guan X, Yu J, Huang X. Lin M, et al. Biochem Biophys Res Commun. 2021 Apr 23;550:127-133. doi: 10.1016/j.bbrc.2021.02.143. Epub 2021 Mar 6. Biochem Biophys Res Commun. 2021. PMID: 33689881
In the present study, we report that MRN-interacting protein, MRNIP, is a novel factor for HR and is crucial for the expression of the MRN complex and loading of recombinases DMC1/RAD51. Knockout of Mrnip in mice led to aberrant synapsis, impaired HR, and male subfe …
In the present study, we report that MRN-interacting protein, MRNIP, is a novel factor for HR and is crucial for the expression of th …
MRNIP is a replication fork protection factor.
Bennett LG, Wilkie AM, Antonopoulou E, Ceppi I, Sanchez A, Vernon EG, Gamble A, Myers KN, Collis SJ, Cejka P, Staples CJ. Bennett LG, et al. Sci Adv. 2020 Jul 10;6(28):eaba5974. doi: 10.1126/sciadv.aba5974. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32832601 Free PMC article.
Here, we identify the MRE11-binding protein MRNIP as a novel fork protection factor that directly binds to MRE11 and specifically represses its exonuclease activity. ...Our findings identify MRNIP as a novel regulator of MRE11 at reversed forks and provide evidence …
Here, we identify the MRE11-binding protein MRNIP as a novel fork protection factor that directly binds to MRE11 and specifically rep …
MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice.
Kazi S, Castañeda JM, Savolainen A, Xu Y, Liu N, Qiao H, Ramirez-Solis R, Nozawa K, Yu Z, Matzuk MM, Prunskaite-Hyyryläinen R. Kazi S, et al. FASEB J. 2022 Sep;36(9):e22479. doi: 10.1096/fj.202101168RR. FASEB J. 2022. PMID: 35920200 Free PMC article.
We demonstrate that Mrnip(-/-) spermatocytes have impaired DNA double-strand break (DSB) repair, they display reduced sex body formation and defective MSCI. We show that Mrnip(-/-) undergoes critical meiocyte loss at the diplotene stage. Furthermore, we determine th …
We demonstrate that Mrnip(-/-) spermatocytes have impaired DNA double-strand break (DSB) repair, they display reduced sex body format …
MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response.
Staples CJ, Barone G, Myers KN, Ganesh A, Gibbs-Seymour I, Patil AA, Beveridge RD, Daye C, Beniston R, Maslen S, Ahel I, Skehel JM, Collis SJ. Staples CJ, et al. Cell Rep. 2016 Sep 6;16(10):2565-2575. doi: 10.1016/j.celrep.2016.07.087. Epub 2016 Aug 25. Cell Rep. 2016. PMID: 27568553 Free PMC article.
Here, we functionally characterize C5orf45 as a binding partner of the MRE11-RAD50-NBS1 (MRN) damage-sensing complex. Hence, we rename C5orf45 as MRNIP for MRN-interacting protein (MRNIP). We find that MRNIP is rapidly recruited to sites of DNA damage. ...Fin …
Here, we functionally characterize C5orf45 as a binding partner of the MRE11-RAD50-NBS1 (MRN) damage-sensing complex. Hence, we rename C5orf …
Whole exome sequencing identifies ABHD14A and MRNIP as novel candidate genes for developmental language disorder.
Bouzid A, Belcadhi M, Souissi A, Chelly M, Frikha F, Gargouri H, Bonnet C, Jebali F, Loukil S, Petit C, Masmoudi S, Hamoudi R, Ben Said M. Bouzid A, et al. Sci Rep. 2025 Jan 2;15(1):367. doi: 10.1038/s41598-024-83115-x. Sci Rep. 2025. PMID: 39747128 Free PMC article.
Analyses of segregation patterns with stringent filtering of the exome data identified disease-causing compound heterozygous variants. In the MRNIP gene, two variants were detected including a synonymous low-frequency variant c.345G > C and a nonsense rare variant c.112 …
Analyses of segregation patterns with stringent filtering of the exome data identified disease-causing compound heterozygous variants. In th …
Ionic strength and composition affect the mobility of surface-modified Fe0 nanoparticles in water-saturated sand columns.
Saleh N, Kim HJ, Phenrat T, Matyjaszewski K, Tilton RD, Lowry GV. Saleh N, et al. Environ Sci Technol. 2008 May 1;42(9):3349-55. doi: 10.1021/es071936b. Environ Sci Technol. 2008. PMID: 18522117

Bare NZVI with an apparent zeta-potential of -30 +/- 3 mV was immobile. Polyaspartate-modified nanoiron (MRNIP) with an apparent zeta-potential of -39 +/- 1 mV was mobile at low ionic strengths (< 40 mM for Na+ and < 0.5 mM for Ca2+), and had a critical deposition co

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Bare NZVI with an apparent zeta-potential of -30 +/- 3 mV was immobile. Polyaspartate-modified nanoiron (MRNIP) with an apparent zeta …