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2003 1
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121 results

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Page 1
MS4A2-rs573790 Is Associated With Aspirin-Exacerbated Respiratory Disease: Replicative Study Using a Candidate Gene Strategy.
Pavón-Romero GF, Pérez-Rubio G, Ramírez-Jiménez F, Ambrocio-Ortiz E, Bañuelos-Ortiz E, Alvarado-Franco N, Xochipa-Ruiz KE, Hernández-Juárez E, Flores-García BA, Camarena ÁE, Terán LM, Falfán-Valencia R. Pavón-Romero GF, et al. Front Genet. 2018 Sep 11;9:363. doi: 10.3389/fgene.2018.00363. eCollection 2018. Front Genet. 2018. PMID: 30254660 Free PMC article.
In C3, we found MS4A2-rs573790C (p = 0.001). Using genetic models, C1 MS4A2-rs57370 CC (p = 0.001), and ACE-rs4309 CC (p = 0.002) had associations. In C2 ACE-rs4309 CC (p = 0.0001) and C3 MS4A2-rs573790 CC (p = 0.001) were also associate with risk. In the sec …
In C3, we found MS4A2-rs573790C (p = 0.001). Using genetic models, C1 MS4A2-rs57370 CC (p = 0.001), and ACE-rs4309 CC (p = 0.0 …
Interaction between antibiotic use and MS4A2 gene polymorphism on childhood eczema: a prospective birth cohort study.
Hua L, Chen Q, Liu QH, Guo YF, Cheng RH, Zhang J, Zhang JH, Wang LW, Ji RX. Hua L, et al. BMC Pediatr. 2021 Jul 14;21(1):314. doi: 10.1186/s12887-021-02786-x. BMC Pediatr. 2021. PMID: 34261469 Free PMC article.
Children with both antibiotic use and MS4A2 rs569108 GG genotype were more likely to develop eczema than those with only antibiotic use or GG homozygote (OR = 6.24 VS. 2.04 or 4.68). CONCLUSIONS: MS4A2 rs569108 polymorphism and antibiotic use were solely associated …
Children with both antibiotic use and MS4A2 rs569108 GG genotype were more likely to develop eczema than those with only antibiotic u …
Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment.
Xie Z, Niu L, Zheng G, Du K, Dai S, Li R, Dan H, Duan L, Wu H, Ren G, Dou X, Feng F, Zhang J, Zheng J. Xie Z, et al. Cell Biosci. 2023 Nov 29;13(1):217. doi: 10.1186/s13578-023-01144-x. Cell Biosci. 2023. PMID: 38031173 Free PMC article.
Five MC signature genes (TPSAB1, TPSB2, CPA3, HPGDS, and MS4A2) were identified, and their average expression was used as a marker of MCs. The MC density was found to be lower in CRC compared to normal tissue, but MCs in CRC demonstrated distinct activation features. ...
Five MC signature genes (TPSAB1, TPSB2, CPA3, HPGDS, and MS4A2) were identified, and their average expression was used as a marker of …
GATA2 and PU.1 Collaborate To Activate the Expression of the Mouse Ms4a2 Gene, Encoding FcepsilonRIbeta, through Distinct Mechanisms.
Ohmori S, Ishijima Y, Numata S, Takahashi M, Sekita M, Sato T, Chugun K, Yamamoto M, Ohneda K. Ohmori S, et al. Mol Cell Biol. 2019 Oct 28;39(22):e00314-19. doi: 10.1128/MCB.00314-19. Print 2019 Nov 15. Mol Cell Biol. 2019. PMID: 31501274 Free PMC article.
In mouse mast cells, however, these factors are coexpressed and activate the expression of the Ms4a2 gene encoding the beta chain of the high-affinity IgE receptor (FcepsilonRI). The present study showed that these factors cooperatively regulate Ms4a2 gene expressio …
In mouse mast cells, however, these factors are coexpressed and activate the expression of the Ms4a2 gene encoding the beta chain of …
Characterization of the methylation patterns of MS4A2 in atopic cases and controls.
Ferreira MA, Oates NA, van Vliet J, Zhao ZZ, Ehrich M, Martin NG, Montgomery GW, Whitelaw E, Duffy DL. Ferreira MA, et al. Allergy. 2010 Mar;65(3):333-7. doi: 10.1111/j.1398-9995.2009.02135.x. Epub 2009 Sep 1. Allergy. 2010. PMID: 19796196
The aim of this study was to characterize the methylation patterns of the membrane-spanning 4-domains, subfamily A, member 2 gene (MS4A2) (beta-chain of the IgE high-affinity receptor), a key gene in the allergic cascade. ...CONCLUSIONS: Methylation levels at the AluSp rep …
The aim of this study was to characterize the methylation patterns of the membrane-spanning 4-domains, subfamily A, member 2 gene (MS4A2 …
Association of the MS4A2 gene promoter C-109T or the 7th exon E237G polymorphisms with asthma risk: a meta-analysis.
Yang HJ, Zheng L, Zhang XF, Yang M, Huang X. Yang HJ, et al. Clin Biochem. 2014 May;47(7-8):605-11. doi: 10.1016/j.clinbiochem.2014.01.022. Epub 2014 Feb 1. Clin Biochem. 2014. PMID: 24495860
BACKGROUND AND OBJECTIVE: A large number of studies have examined the association between the Membrane-spanning 4 domains, superfamily A, number 2 (MS4A2) gene C-109T (rs1441586) or E237G (rs569108) variants and asthma risk. However, the results are inconsistent and inconc …
BACKGROUND AND OBJECTIVE: A large number of studies have examined the association between the Membrane-spanning 4 domains, superfamily A, nu …
Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response.
Dekkers KF, Slieker RC, Ioan-Facsinay A, van Iterson M; BIOS consortium; Ikram MA, van Greevenbroek MMJ, Veldink JH, Franke L, Boomsma DI, Slagboom PE, Jukema JW, Heijmans BT. Dekkers KF, et al. Nat Commun. 2023 Feb 1;14(1):544. doi: 10.1038/s41467-022-35663-x. Nat Commun. 2023. PMID: 36725846 Free PMC article.
Indeed, a Mendelian randomization approach based on GWAS summary statistics indicates that several of these genes, including interleukin-4 (IL4) and IgE receptors (FCER1A, MS4A2), affect the incidence of allergic diseases. Our findings highlight the interplay between trigl …
Indeed, a Mendelian randomization approach based on GWAS summary statistics indicates that several of these genes, including interleukin-4 ( …
MS4A Cluster in Alzheimer's Disease.
Ma J, Yu JT, Tan L. Ma J, et al. Mol Neurobiol. 2015;51(3):1240-8. doi: 10.1007/s12035-014-8800-z. Epub 2014 Jul 1. Mol Neurobiol. 2015. PMID: 24981432 Review.
Besides, although the MS4A family members are poorly characterized, an important role in immunity has already been identified for several members of this cluster (such as MS4A1, MS4A2, and MS4A4B), indicating the possible involvement of MS4A gene cluster in AD pathogenesis …
Besides, although the MS4A family members are poorly characterized, an important role in immunity has already been identified for several me …
A polymorphism of MS4A2 (- 109T > C) encoding the beta-chain of the high-affinity immunoglobulin E receptor (FcepsilonR1beta) is associated with a susceptibility to aspirin-intolerant asthma.
Kim SH, Bae JS, Holloway JW, Lee JT, Suh CH, Nahm DH, Park HS. Kim SH, et al. Clin Exp Allergy. 2006 Jul;36(7):877-83. doi: 10.1111/j.1365-2222.2006.02443.x. Clin Exp Allergy. 2006. PMID: 16839402
BACKGROUND AND OBJECTIVE: The MS4A2 gene, the beta chain of the high-affinity receptor for immunoglobulin (Ig)E, has previously been linked to atopy and asthma. ...In addition, luciferase reporter assays also showed that the FcepsilonR1beta-109T allele was associated with …
BACKGROUND AND OBJECTIVE: The MS4A2 gene, the beta chain of the high-affinity receptor for immunoglobulin (Ig)E, has previously been …
A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survival.
Cruse G, Kaur D, Leyland M, Bradding P. Cruse G, et al. FASEB J. 2010 Oct;24(10):4047-57. doi: 10.1096/fj.10-158378. Epub 2010 Jun 16. FASEB J. 2010. PMID: 20554927 Free PMC article.
We demonstrate the expression of a novel MS4A2 truncation lacking exon 3 in human mast cells termed MS4A2(trunc). MS4A2(trunc) gene expression was regulated negatively by the mast cell growth factor stem cell factor (SCF), and its expression was not detected …
We demonstrate the expression of a novel MS4A2 truncation lacking exon 3 in human mast cells termed MS4A2(trunc). MS4A2 …
121 results