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1991 4
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1,319 results

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Page 1
PRMT1-methylated MSX1 phase separates to control palate development.
Meng L, Jiang Y, You J, Chen Y, Guo S, Chen L, Ma J. Meng L, et al. Nat Commun. 2025 Jan 22;16(1):949. doi: 10.1038/s41467-025-56327-6. Nat Commun. 2025. PMID: 39843447 Free PMC article.
Here, we show that MSX1 phase separation is a vertebrate-conserved mechanism underlying embryonic palatal fusion. Notably, MSX1 phase separation is triggered by its intrinsically disordered protein region (IDR) and regulated by PRMT1-catalyzed methylation, specifica …
Here, we show that MSX1 phase separation is a vertebrate-conserved mechanism underlying embryonic palatal fusion. Notably, MSX1 …
Phosphorylation of MSX1 controls tumorigenesis and bone development through targeting FBXW7 degradation.
Yang Y, Jia X, Peng Y, Lu S, Wang C, Zhang H, Wang X, Zhou Q, Sun Y, Wang G. Yang Y, et al. Cancer Lett. 2025 Oct 28;631:217948. doi: 10.1016/j.canlet.2025.217948. Epub 2025 Jul 23. Cancer Lett. 2025. PMID: 40712969
The transcription factor MSX1, typically expressed in early development but not in most adult tissues, is often re-activated in various cancers, although its underlying oncogenic mechanisms remain elusive. Here, we found that MSX1 promotes the degradation of FBXW7, …
The transcription factor MSX1, typically expressed in early development but not in most adult tissues, is often re-activated in vario …
MSX1 mutations and associated disease phenotypes: genotype-phenotype relations.
Liang J, Von den Hoff J, Lange J, Ren Y, Bian Z, Carels CE. Liang J, et al. Eur J Hum Genet. 2016 Dec;24(12):1663-1670. doi: 10.1038/ejhg.2016.78. Epub 2016 Jul 6. Eur J Hum Genet. 2016. PMID: 27381090 Free PMC article. Review.
The Msx1 transcription factor is involved in multiple epithelial-mesenchymal interactions during vertebrate embryogenesis. ...This information provides new insights for genetic diagnosis and for further functional analysis of MSX1 variants....
The Msx1 transcription factor is involved in multiple epithelial-mesenchymal interactions during vertebrate embryogenesis. ...This in …
MSX1 gene in the etiology orofacial deformities.
Paradowska-Stolarz A. Paradowska-Stolarz A. Postepy Hig Med Dosw (Online). 2015 Dec 31;69:1499-504. Postepy Hig Med Dosw (Online). 2015. PMID: 27259221 Review.
The muscle segment homeobox (MSX1) gene plays a crucial role in epithelial-mesenchymal tissue interactions in craniofacial development. ...Among the candidate genes whose mutations could lead to formation of the cleft, the MSX1 homeobox gene is mentioned. Mutations …
The muscle segment homeobox (MSX1) gene plays a crucial role in epithelial-mesenchymal tissue interactions in craniofacial developmen …
MSX1 gene polymorphisms and non-syndromic cleft lip with or without palate (NSCL/P): A meta-analysis.
Tasanarong P, Pabalan N, Tharabenjasin P, Jarjanazi H. Tasanarong P, et al. Oral Dis. 2019 Sep;25(6):1492-1501. doi: 10.1111/odi.13127. Epub 2019 Jun 25. Oral Dis. 2019. PMID: 31132300 Review.
Association study outcomes between single nucleotide polymorphisms (SNPs) near the muscle segment homeobox gene 1 (MSX1) and NSCL/P have been inconsistent. This compels a meta-analysis to obtain more precise estimates. ...All these significant outcomes were deemed robust b …
Association study outcomes between single nucleotide polymorphisms (SNPs) near the muscle segment homeobox gene 1 (MSX1) and NSCL/P h …
Homeoprotein Msx1-PIASy Interaction Inhibits Angiogenesis.
Son MJ, Rho SB, Kim K, Oh M, Son C, Song SY, Park K. Son MJ, et al. Cells. 2020 Aug 7;9(8):1854. doi: 10.3390/cells9081854. Cells. 2020. PMID: 32784646 Free PMC article.
Interestingly, PIASy stabilized Msx1 protein, whereas deletion of the Msx1-interacting domain in PIASy abrogated the inhibition of tube formation and the stabilization of Msx1 protein. Our findings suggest the functional importance of PIASy-Msx1 intera …
Interestingly, PIASy stabilized Msx1 protein, whereas deletion of the Msx1-interacting domain in PIASy abrogated the inhibitio …
MSX1-expression during the different phases in healthy human endometrium.
Eppich S, Kuhn C, Schmoeckel E, Mayr D, Mahner S, Jeschke U, Gallwas J, Heidegger HH. Eppich S, et al. Arch Gynecol Obstet. 2023 Jul;308(1):273-279. doi: 10.1007/s00404-023-07033-5. Epub 2023 Apr 27. Arch Gynecol Obstet. 2023. PMID: 37101223 Free PMC article.
CONCLUSION: MSX1 is known as a member of the muscle segment homeobox gene family. MSX1 is a p53-interacting protein and overexpression of homeobox MSX1 induced apoptosis of cancer cells. ...Because MSX1 is known to be downregulated by progesterone, the …
CONCLUSION: MSX1 is known as a member of the muscle segment homeobox gene family. MSX1 is a p53-interacting protein and overex …
MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity.
Lee JM, Qin C, Chai OH, Lan Y, Jiang R, Kwon HE. Lee JM, et al. J Dent Res. 2022 Jul;101(7):832-839. doi: 10.1177/00220345211070583. Epub 2022 Feb 3. J Dent Res. 2022. PMID: 35114852 Free PMC article.
In this study, we found that Sostdc1/Wise, another secreted Wnt antagonist, is involved in regulating the odontogenic pathway downstream of Msx1. Whereas Sostdc1 expression in the developing tooth germ was not increased in Msx1(-/-) embryos, genetic inactivation of …
In this study, we found that Sostdc1/Wise, another secreted Wnt antagonist, is involved in regulating the odontogenic pathway downstream of …
Msx1 cooperates with Runx1 for inhibiting myoblast differentiation.
Zhou G, Yang Y, Zhang X, Wang J. Zhou G, et al. Protein Expr Purif. 2021 Mar;179:105797. doi: 10.1016/j.pep.2020.105797. Epub 2020 Nov 24. Protein Expr Purif. 2021. PMID: 33242573
However, the molecular mechanism through which Msx1 coordinates myogenesis remains to be elucidated. Here, we determine the interacting partner proteins of Msx1 in myoblast cells by a proteomic screening method. Msx1 is found to interact with 55 proteins, amo …
However, the molecular mechanism through which Msx1 coordinates myogenesis remains to be elucidated. Here, we determine the interacti …
Msx1 is essential for proper rostral tip formation of the mouse mandible.
Shibuya S, Nakatomi M, Kometani-Gunjigake K, Nakao-Kuroishi K, Matsuyama K, Kataoka S, Toyono T, Seta Y, Kawamoto T. Shibuya S, et al. Biochem Biophys Res Commun. 2023 Jan 29;642:75-82. doi: 10.1016/j.bbrc.2022.12.047. Epub 2022 Dec 18. Biochem Biophys Res Commun. 2023. PMID: 36566565
Normal Msx1 expression was observed in the rostral end of the developing mandible; however, a reduced expression of Msx1 was observed in the soft tissue of the mandibular tip than in the lower incisor bud region. ...Our results indicate that Msx1 is indispens …
Normal Msx1 expression was observed in the rostral end of the developing mandible; however, a reduced expression of Msx1 was o …
1,319 results